1.

Record Nr.

UNINA9910811529203321

Titolo

Variational methods : open problems, recent progress, and numerical algorithms, June 5-8, 2002, Northern Arizona University, Flagstaff, Arizona / / John M. Neuberger, editor

Pubbl/distr/stampa

Providence, Rhode Island : , : American Mathematical Society, , [2004]

©2004

ISBN

0-8218-7947-2

0-8218-3339-1

Descrizione fisica

1 online resource (298 p.)

Collana

Contemporary mathematics, , 0271-4132 ; ; 357

Disciplina

515/.3533

Soggetti

Differential equations, Elliptic

Variational inequalities (Mathematics)

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

""Contents""; ""Introduction to the Proceedings""; ""Semilinear Equations with Discrete Spectrum""; ""Semilinear Elliptic Boundary Value Problems with Nonlinear Oblique Boundary Conditions, a Boundary Element Monotone Iteration Approach""; ""A Note on the Elliptic Sine-Gordon Equation""; ""Convergence Analysis of an Optimal Scaling Algorithm for Semilinear Elliptic Boundary Value Problems""; ""Sobolev Gradients: Introduction, Applications, Problems""; ""Unbounded Perturbations of Resonant Schrodinger Equations""; ""Quasilinear Boundary Value Problems: Existence and Multiplicity Results""

""Eigenvalue Problems, Resonance Problems and Open Problems""""Variational, Dynamic and Geometric Aspects of Some Nonlinear Problems""; ""The Perturbed p-Laplacian and Quadratic Growth""; ""Variational Methods for Ill-Posed Problems""; ""GNGA: Recent Progress and Open Problems for Semilinear Elliptic PDE""; ""Critical Nonlinearities and Symmetric Solutions""; ""Non-convergent Radial Solutions of a Semilinear Elliptic Equation in RN""; ""Traveling Wave Solutions to Nonlinear Evolution Equations""



2.

Record Nr.

UNINA9910484242303321

Autore

Brouns Inge

Titolo

The Pulmonary Neuroepithelial Body Microenvironment : A Multifunctional Unit in the Airway Epithelium / / by Inge Brouns, Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen

Pubbl/distr/stampa

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021

ISBN

3-030-65817-1

Edizione

[1st ed. 2021.]

Descrizione fisica

1 online resource (XVIII, 99 p. 22 illus., 21 illus. in color.)

Collana

Advances in Anatomy, Embryology and Cell Biology, , 2192-7065 ; ; 233

Disciplina

612.8

Soggetti

Neurosciences

Physiology

Neurochemistry

Respiratory organs - Diseases

Neuroscience

Pneumology

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di contenuto

Pulmonary sensory receptors -- The pulmonary NEB ME is a complex intraepithelial unit -- Studying the pulmonary NEB ME: a multidisciplinary approach -- Functional exploration of the pulmonary NEB ME -- Concluding remarks and future perspectives -- References -- ADDENDUM.

Sommario/riassunto

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest



has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters andare closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.