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Record Nr. |
UNINA9910811479203321 |
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Autore |
Hill Shannen L. <1964-> |
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Titolo |
The Biko's ghost : the iconography of black consciousness / / Shannen L. Hill |
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Pubbl/distr/stampa |
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Minneapolis, Minnesota ; ; London, [England] : , : University of Minnesota Press, , 2015 |
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©2015 |
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Descrizione fisica |
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1 online resource (415 p.) |
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Classificazione |
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ART015000HIS047000SOC031000 |
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Disciplina |
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Soggetti |
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Black people in art |
Black people in popular culture - Race relations |
Art and social action - Race relations |
South Africa Race relations |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Machine generated contents note: Contents Abbreviations -- Introduction: Let's Talk about Consciousness -- 1. Shaping Modern Black Culture in the 1970's -- 2. Of Icons and Inquests: "Steve Biko, God Be with You, BPC" -- 3. Contemplating Death: Artists and Abjection -- 4. Creating a Culture of Resistance -- 5. Silencing the Censors: Black Consciousness between the Lines in the 1980's -- 6. Transitions and Truths in a New Democracy -- 7. Museum, Monument, Marking: Black Consciousness in the New Millennium -- Epilogue: "After Such a Long Time His Life Is Still Dug Out" -- Acknowledgments: I Write What I Must -- Notes -- Bibliography -- Index. |
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Sommario/riassunto |
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""When you say, 'Black is Beautiful,' what in fact you are saying. is: Man, you are okay as you are; begin to look upon yourself as a human being." With such statements, Stephen Biko became the voice of Black Consciousness. And with Biko's brutal death in the custody of the South African police, he became a martyr, an enduring symbol of the horrors of apartheid. Through the lens of visual culture, Biko's Ghost reveals how the man and the ideology he promoted have profoundly influenced liberation politics and race discourse--in South Africa and around the |
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globe--ever since. Tracing the linked histories of Black Consciousness and its most famous proponent, Biko's Ghost explores the concepts of unity, ancestry, and action that lie at the heart of the ideology and the man. It challenges the dominant historical view of Black Consciousness as ineffectual or racially exclusive, suppressed on the one side by the apartheid regime and on the other by the African National Congress. Engaging theories of trauma and representation, and icon and ideology, Shannen L. Hill considers the martyred Biko as an embattled icon, his image portrayals assuming different shapes and political meanings in different hands. So, too, does she illuminate how Black Consciousness worked behind the scenes throughout the 1980's, a decade of heightened popular unrest and state censorship. She shows how--in streams of imagery that continue to multiply nearly forty years on--Biko's visage and the ongoing life of Black Consciousness served as instruments through which artists could combat the abuses of apartheid and unsettle the "rainbow nation" that followed. "-- |
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2. |
Record Nr. |
UNINA9910300208003321 |
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Titolo |
Targeted Therapy of Acute Myeloid Leukemia / / edited by Michael Andreeff |
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Pubbl/distr/stampa |
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New York, NY : , : Springer New York : , : Imprint : Springer, , 2015 |
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ISBN |
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Edizione |
[1st ed. 2015.] |
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Descrizione fisica |
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1 online resource (804 p.) |
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Collana |
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Current Cancer Research, , 2199-2592 |
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Disciplina |
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Soggetti |
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Cancer |
Pharmacology |
Cytology |
Microbiology |
Cancer Biology |
Cell Biology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Introduction/Perspective -- Genetics and Classification of Acute Myeloid Leukemia -- Proteomics of AML to guide Selection of Therapy -- Roles of Apoptosis Regulating Bcl-2-Family Genes in AML -- Bcl-2 family: Translational aspects -- IAP Family and Proteins as Therapeutic Targets for Acute Myeloid Leukemia -- TP53 Mutations in Acute Myeloid Leukemia -- Targeting p53 Tumor Suppressor for AML Therapy -- AML-Selective Apoptosis Induction by rationally designed Death Ligand Fusion Protein -- PIM Kinases in AML -- Development of Midostaurin as a Tyrosine Kinase Inhabitor -- FLT3 in AML -- FLT3-ITD. Clinical (Sorafenib/AC220) -- Nucleophosmin (NPM1) -- Raf/MEK Pathway -- The Role of Translational Medicine in Optimization of Therapies targeting the RAS-MAP Kinase Pathway -- Clinical Use of Farnesyltransferase Inhititors -- The P13K-AKT-mTOR signaling Network in AML -- Targeting the P13 Kinase-mTOR Signaling Pathway in AML -- Aurora kinases -- The Clinical Development of Aurora Kinase Inhibitors in Acute Myeloid Leukemia -- AML-Deacetylases -- Methylation in AML-Clinical Applications -- Topic: RARa/RXR Part: Basic -- Arsenic Trioxide in Untreated APL -- Targeting PML-RARα with Retinoids -- NR4A Orphan Receptors as Drug Targets -- Antibody-based Therapeutics Targeting CD33, CD45, and CD66 -- New Heterogeneity of the Leukemic Stem Cells -- Targeting Leukemia Stem Cells -- Regulation of Hematopoiesis by CXCL12/CXCR4 Signaling -- CXC4/CXCL12 as a Therapeutic Target -- VLA-4: A Cell’s Consequential Encounter -- VLA-4 Function and Prognosis in Acute Myeloid Leukemia -- VLA4 in Acute Lymphoblastic Leukemia -- The Leukemic Bone Marrow Microenvironment: Targeting Hypoxia with Hypoxia Activated Pro-Drugs -- Topic: miRs as Therapeutic Targets -- Clinical Implications of MicroRNAs in AML -- Inhibition of Glycolysis as a Therapeutic Strategy in Acute Myeloid Leukemias -- Molecular and Biochemical Basis for the Reprogramming of Intermediary Metabolism in Leukemia Cells -- NK Cell Immunotherapy for AML -- Allogeneicand Autologous T cell Strategies to Enhance Targeting of Acute Myeloid Leukemia -- Indications for Hematopoietic Transplantation for AML -- Mesenchymal Stem/Stromal Cell Targeted Therapies for Solid Tumors and Hematological Malignancies. |
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Sommario/riassunto |
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This book provides an unprecedented overview of targeted therapies for acute myeloid leukemias. The volume provides comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Authoritative chapters are written by leading research scientists and clinicians, who explain basic concepts and the clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML. The chapter topics include the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53, and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. In addition, chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells, and leukemia metabolism, provide insight into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies complete the overview of the multi-dimensional therapeutic landscape, where leukemia specialists develop treatment strategies, which are expected to bring forth critical breakthroughs in the field of leukemia. . |
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