Assessment of future scientific needs for live variola virus / / Committee on the Assessment of Future Scientific Needs for Live Variola Virus, Board on Global Health, Institute of Medicine

• Record Nr.: UNINA9910811409703321
• Pubbl/distr/stampa: Washington, D.C., : National Academy Press, 1999
• ISBN: 0-309-17319-1; 1-280-18599-6; 9786610185993; 0-309-59698-X; 0-585-06800-3
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (126 pages) : illustrations
• Collana: The compass series
• Disciplina: 616.9/12
• Soggetti: Smallpox - Research; Smallpox - Prevention; Smallpox vaccine; Virology - Cultures and culture media
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di bibliografia: Includes bibliographical references (p. 87-91).
• Nota di contenuto: Assessment of Future Scientific Needs for Live Variola Virus -- Copyright -- Preface -- Acknowledgments -- REVIEWERS -- Contents -- Executive Summary -- SCOPE -- SCIENTIFIC NEEDS FOR LIVE AND REPLICATION-DEFECTIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- Part I Introduction -- 1 Introduction -- BACKGROUND -- CONTEMPORARY CONTEXT -- SCOPE -- SCIENTIFIC NEEDS FOR VARIOLA VIRUS -- ORGANIZATION OF THIS REPORT -- Part II Smallpox and Its Control -- 2 Variola Virus and Other Orthopoxviruses -- GENERAL ATTRIBUTES OF ORTHOPOXVIRUSES -- POXVIRUS REPLICATION -- PROPERTIES OF SPECIFIC ORTHOPOXVIRUSES -- 3 Clinical Features of Smallpox -- ENTRY AND INFECTION -- DISSEMINATION -- THE RASH -- LESIONS OF THE MUCOUS MEMBRANES -- EFFECTS ON OTHER ORGANS -- IMMUNE RESPONSE -- IMMUNITY AGAINST SMALLPOX -- 4 Epidemiology -- CHARACTERISTICS OF HISTORICAL OUTBREAKS -- LIKELY CHARACTERISTICS OF FUTURE ; SMALLPOX OUTBREAKS -- CONTROL STRATEGIES -- 5 Variola Virus Stocks Following Eradication of Smallpox -- ESTABLISHMENT OF INTERNATIONAL REPOSITORIES -- DECISION BY THE WORLD HEALTH ASSEMBLY TO DESTROY VARIOLA VIRUS STOCKS -- U.S. RESEARCH ON SMALLPOX -- RESEARCH AT CDC AND USAMRIID -- Part III Scientific Needs for Variola Virus -- 6 Development of Antiviral Agents -- IN VITRO ASSAYS -- ANIMAL MODELS -- 7 Development of Vaccines -- CURRENT STATUS OF VACCINIA VACCINE PREPARATIONS -- EVALUATION OF VACCINIA VACCINE DERIVED FROM TISSUE CULTURE -- EVALUATION OF NOVEL VACCINES -- 8 Detection and Diagnosis -- ENVIRONMENTAL DETECTION -- DIAGNOSIS OF INFECTION -- ALTERNATIVES TO LIVE VIRUS -- 9 Bioinformatics -- VARIABILITY OF VARIOLA VIRUS -- POTENTIAL DEVELOPMENTS -- 10 Understanding of the Biology of Variola Virus -- VIRUS-CELL INTERACTIONS -- VIRUS-HOST INTERACTIONS -- 11 Research on the Expressed Protein Products of Variola -- SYNTHESIS OF VARIOLA PROTEINS.; POTENTIAL UTILITY OF VARIOLA PROTEINS -- Part IV Findings -- 12 Summary and Conclusions -- THE BROADER CONTEXT -- SCIENTIFIC NEEDS FOR LIVE VARIOLA VIRUS -- OVERALL CONCLUSIONS -- References -- Appendix A Glossary -- Appendix B Acronyms -- Appendix C Committee and Staff Biographies -- Staff.