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1. |
Record Nr. |
UNINA9910810320403321 |
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Titolo |
Advances in evolutionary developmental biology / / edited by J. Todd Streelman |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley-Blackwell, , 2014 |
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©2014 |
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ISBN |
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1-118-70744-3 |
1-118-70746-X |
1-118-70734-6 |
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Descrizione fisica |
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1 online resource (255 p.) |
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Altri autori (Persone) |
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StreelmanJ. Todd (Jeffrey Todd) |
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Disciplina |
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Soggetti |
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Developmental biology |
Evolution (Biology) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Cover; Title page; Copyright page; Contents; Preface; Contributors; 1: "The Genetic Tool-Kit": The Life-History of an Important Metaphor; Introduction; Historical Background to the Term; From "Homeotic Genes" (and "Homeoboxes") to the General Idea of Key Regulatory Genes with Conserved Developmental Functions; The Genetic Tool-Kit: The Seminal Findings That Led to its Coinage and the Key Idea; The Genetic Tool-Kit as a Non-Answer to the Question of Evolutionary Diversification within the Animal Kingdom; Thinking about How GRNs Are "Rewired": Two Approaches; Conclusions; Acknowledgments |
References2: The Evolution of Sex Determination in Animals; Introduction; Evo-Devo of Sex Determination; The Origin of Network Novelty; Evolution of Genotypic Sex Determination; The Developmental Basis of GSD; Evolutionary Transitions between Genotypic Sex-Determining Systems; GSD and the Evolution of Sex Chromosomes; Evolution of Environment-Dependent Sex Determination; The Developmental Basis of ESD; Evolutionary Transitions between Environment-Dependent Sex-Determining Systems; From ESD to GSD and Back Again; Suggestions for Future Work; Acknowledgments; References |
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3: The Evolution and Development of Eusocial Insect BehaviorThe Path from Solitary Life to Advanced Social Living; Eusociality: Defining the Extremes of Social Life; The Starting Point: A Solitary Life Cycle; Aggregations; Communal Nesting; Primitive Eusociality; Advanced Eusociality; Ultimate Explanations for Reproductive Division of Labor; What Could Natural Selection Act Upon to Build Eusocial Insect Societies?; Genomic Approaches; A Targeted Approach: Social Co-Option of Solitary Ground Plans; Reproductive Physiology as a Behavioral Regulator; Reproductive Ground Plan Hypothesis |
Epigenetics: A New Understanding of the Regulation of Social LifeGenomic Patterns of DNA Methylation: A Substrate for Natural Selection?; The Proposed Functional Roles of DNA Methylation; The Role of DNA Methylation in Eusocial Developmental Plasticity and Evolution; The Putative Role of DNA Methylation in Behavior and Social Behavioral Evolution; Social Insect Evolution: A Quickly Advancing Field; References; 4: Evo-Devo on Chip; Introduction; Interrogating Developmental Mechanisms in Drosophila melanogaster Using Microdevices |
Microfluidic Advances for Developmental and Behavioral Studies in C. elegansMicrofluidic Culture Systems for Studying Genetic and Environmental Effects on D. rerio Development; Mammalian Embryonic Development in Microsystems; Conclusion; References; 5: From Black and White to Shades of Gray: Unifying Evo-Devo through the Integration of Molecular and Quantitative Approaches; Introduction; The Geometry of Development: A Quantitative Approach; A Brief Review of GMs; How GM Can Be Used to Study the Evolution of Development |
Size and Shape Relationships: How Can Allometry Inform Us about the Process of Evolution? |
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Sommario/riassunto |
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Providing outstanding breadth of coverage in evo-devo, Advances in Evolutionary Developmental Biology provides a comprehensive review of the milestones of research in evolution and development and outlines the exciting research agenda for the field going forward. Compiling the viewpoints of a diverse group of field experts, this timely text expands the now-mature science of evo-devo into more complex areas of research. This essential reference is destined to become the go-to source for ideas and hypotheses for a new generation of graduate students in evolutionary and developmental biolo |
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2. |
Record Nr. |
UNINA9910300201903321 |
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Titolo |
Cancer Immunology : A Translational Medicine Context / / edited by Nima Rezaei |
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Pubbl/distr/stampa |
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Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2015 |
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ISBN |
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Edizione |
[1st ed. 2015.] |
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Descrizione fisica |
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1 online resource (633 p.) |
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Disciplina |
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Soggetti |
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Internal medicine |
Immunology |
Oncology |
Hematology |
Internal Medicine |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction on cancer immunology and immunotherapy -- Inflammatory and innate immune cells in cancer microenvironment and progression -- Role of innate immunity in cancers and antitumor response -- Role of B cells in anti tumor response -- The role of exhaustion in tumor-induced T cell dysfunction in patients with cancer -- Regulatory T cells and Th17 cells in the immunosuppressive tumor network -- Role of cytokines in tumor immunity and immune tolerance to cancers -- Role of chemokines and chemokine receptors in cancers -- The role of Fas and Fas-ligand in cancers -- MHC class I molecules and cancer progression: Lessons learned from preclinical tumor models -- Role of plasmacytoid dendritic cells in cancer -- Cancer immunoediting: immunosurveillance, immuneequilibrium, and immune escape -- Apoptosis, autophagy and necroptosis in Cancer -- Prognostic value of innate and adaptive immunity in cancers -- Epigenetics and Micro RNAs in cancers -- Immunogenetics of cancers |
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-- Immunodeficiencies and cancers -- Immunosenescence and cancers -- Nutrition, immunity and cancers -- Allergies and cancers -- Cancer immunology of transmissible cancers -- Systems biology and systems immunology of cancer -- Principles of immunological diagnostic tests for cancers -- Flow cytometry in cancer immunotherapy: applications, analysis, quality control and future -- Immunohistochemistry of cancers -- Immunology and immunotherapy of graft versus host disease. . |
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Sommario/riassunto |
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Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology. . |
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