Molecular aspects of infectious disease [[electronic resource] /] / Mazen T. Saleh, editor

• Record Nr.: UNINA9910809637103321
• Pubbl/distr/stampa: New York, : Nova Science Publishers, c2011
• ISBN: 1-61761-251-0
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (214 p.)
• Collana: Immunology and immune system disorders; Nova biomedical
• Altri autori (Persone): SalehMazen T
• Disciplina: 616.9/0471
• Soggetti: Molecular microbiology; Communicable diseases - Molecular aspects; Pathology, Molecular
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- MOLECULAR ASPECTS OF INFECTIOUS DISEASE -- MOLECULAR ASPECTS OF INFECTIOUS DISEASE -- Library of Congress Cataloging-in-Publication Data -- Contents -- Chapter I Overview -- Epidemiology -- Host-Pathogen Interaction -- Emerging Infectious Diseases -- Chapter II Structure and Function of Bacterial and Fungal Cell Walls -- Bacterial Cell Walls -- Gram-Positive Cell Walls -- Mycobacterial Cell Walls -- Gram-Negative Cell Walls -- Fungal Cell Walls -- Conclusion -- References -- Chapter III Bacterial Cell Surface Structures Important in Pathogenesis -- Importance of the Bacterial Cell Surface -- Bacterial Capsules and Slime Layers -- S-Layers -- References -- Chapter IV An Introduction to Protein Secretion in Prokaryotes -- Type I Secretion System (T1ss) -- Architecture -- Mechanism of Transport -- Protein Folding -- Summary -- Type II Secretion System (T2ss) -- General Secretory Pathway (Gsp) -- Architecture -- Mechanism of Transport -- Protein Folding -- Twin Arginine Translocation (Tat) Pathway -- Architecture -- Mechanism of Transport -- Outer Membrane Transport -- Summary -- Type III Secretion System (T3ss) -- Architecture -- Mechanism of Transport -- Summary -- Type IV Secretion System (T4ss) -- Architecture -- Mechanism of Transport -- Summary -- Type V Secretion System (T5ss) -- Autotransporters (Va) -- Two-Partner Secretion (Vb) -- ; Oligomeric Coiled-Coil Adhesins (Vc) -- Summary -- Type VI Secretion System (T6ss) -- Architecture and Mechanism of Transport -- Summary -- Type VII Secretion System (T7ss) -- Architecture and Mechanism of Transport -- Summary -- Conclusion -- References -- Chapter V Viruses -- Basic Structure -- The Viral Lifecycle within Host Cells -- Survey of Medically Important Viruses -- Therapeutic Strategies -- References -- Chapter VI The Innate Immune System -- Abstract -- 1. General Description.; 2. Nature of the Innate Immune System Repertoire -- 3. Mechanisms of Recognition by the Innate System - Receptor-Specific Responses -- I. Secreted PRR -- II. Cytoplasmic PRR -- III. Cell Surface Receptors -- Toll-Like Receptors -- 4. Cell Types and Processes Involved in the Innate Immune System -- I. Innate Barriers to Infection -- II. Innate Immune Cells -- II. Innate Immune Cells -- IV. Cytokine and Chemokine Production -- 5. Inflammatory Responses -- 6. Antigen Processing - Role of Innate Immunity in Stimulating Adaptive Immune Responses -- 7. Disorders of the Innate Immune System -- References -- Chapter VII Respiratory Infections -- Abstract -- Introduction -- Pulmonary Infections -- Streptococcus Pneumoniae -- Colonization of Upper Airways -- Invasion and Dissemination -- Immune Defense and Inflammation -- Immune Evasion -- PSEUDOMONAS AERUGINOSA -- Clinical Significance -- Pseudomonas Aeruginosa in CF -- Mechanisms of Microbial Pathogenesis -- Apoptosis of Host Cells Caused by Pseudomonas Aeruginosa -- Molecular Mechanisms of Inflammation Caused by Pseudomonas Aeruginosa Infection -- The Role of Airway Epithelial Cells in the Pathogenesis of Pseudomonas Aeruginosa Pulmonary Infections -- Immune Evasion -- Conclusion -- References -- Chapter VIII Prions -- Abstract -- Introduction -- Infectious but Proteinaceous Pathogens -- Isolation of Infectious Agents Composed of Proteins only -- Identification of Prp Gene -- Protein-only Hypothesis -- Isoforms of Prion Protein: PrPc and PrPsc -- PrPc Function in Physiology and Prion Pathogenesis -- Structure of PrPc and PrPsc -- Models of PrPsc Aggregates -- Prion Replication -- Conclusion -- Acknowledgments -- References -- Chapter IX Transmissible Spongiform Encephalopathy (TSE) -- Abstract -- Introduction -- Transmission of TSEs -- Species Barrier -- Prion Strain -- Prion Pathogenesis.; TSEs in Humans and Animals -- Clinical and Pathological Features -- Human TSEs -- Idiopathic TSEs: sCJD and Sporadic Fatal Insomnia -- Inherited TSEs: fCJD, GSS and FFI -- Acquired TSEs: kuru, iCJD, and vCJD -- Animal TSes -- Scrapie -- BSE -- CWD -- Other Animal TSEs -- Conclusion -- Acknowledgments -- References -- Chapter X Diagnostic Microbiology -- Abstract -- Introduction -- Direct Examination and Antigen Testing -- Microscopic Examination -- Common Stain Methods -- Biochemical and Antigen Testing -- Microorganism and Virus Culture -- Primary Alive Culture -- Culture using Living Cells -- Immunological Diagnosis -- Immunofluorescence Methods -- Enzyme Immunoassays -- Immunoblotting -- Other Serologic Techniques -- Molecular Diagnosis -- Nucleic Acid Extraction -- Non-Amplified Probe Methods -- Amplification Methods -- Signal Amplification -- PCR-Target Amplification -- Real Time PCR -- Post Amplification Analyses -- Colorimetric ELISA -- Reverse Hybridization -- Solid Nucleic Acid Arrays -- Suspension Array Analysis -- Sequencing -- Conclusion -- Acknowledgments -- References -- Index.