Radiation oncology primer and review : essential concepts and protocols / / George Rodrigues, Vikram Velker, Lara Best

• Record Nr.: UNINA9910808664003321
• Autore: Rodrigues George
• Pubbl/distr/stampa: New York, : Demos Medical Publishing, 2013
• ISBN: 1-61705-166-7
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (375 p.) : illustrations
• Altri autori (Persone): VelkerVikram; BestLara
• Disciplina: 616.9940642
• Soggetti: Cancer - Radiotherapy; Cancer - Treatment
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Title; Copyright; Dedication; Contents; Preface; Acknowledgments; Abbreviations; List of Tables; List of Figures; Part I: Basic Science Concepts; 1. Physics; Key Points; 1.1. Electromagnetic Radiation; 1.2. Structure of Matter; 1.3. Radioactive Decay and Radionuclides; 1.4. Ionizing Radiation; 1.5. X-Ray Production; 1.6. Radiation Measurement; 1.7. Isodose Curves; 2. Biology; Key Points; 2.1. What is Cancer?; 2.2. Cell Cycle and Proliferation; 2.3. Cell Immortality and Death; 2.4. Tumor Heterogeneity; 2.5. Angiogenesis; 2.6. Tumor Microenvironment; 2.7. Tumor Hypoxia and Reoxygenation; 2.8. Invasion and Metastases2.9. Cancer Genetics; 2.10. Heritable Cancer; 3. Radiobiology; Key Points; 3.1. Radiation Interactions at the Molecular Level; 3.2. Cell Survival Curves; 3.3. Cell Killing Models; 3.4. Mitotic Cell Cycle; 3.5. Dna Damage and Repair; 3.6. Radiosensitivity and Radioresistance; 3.7. Tumor Response; 3.8. Acute and Late Normal Tissue Responses; 3.9. Time, Dose, and Fractionation Considerations; 3.10. Issues in Human Radiation Exposure; 4. Pathology; Key Points; 4.1. Introduction; 4.2. Specimen Acquisition; 4.3. Macroscopic Evaluation; 4.4. Microscopic Evaluation; 4.5. Cytological Evaluation4.6. Immunohistochemistry; 4.7. Electron Microscopy; 4.8. Terminology; 5. Radiation Pathophysiology; Key Points; 5.1. Tissue and Organ Radiation Injury; 5.2. Dose-Volume Histograms; 5.3. Brain; 5.4. Optic Nerve and Chiasm; 5.5. Brainstem; ; 5.6. Spinal Cord; 5.7. Inner Ear/Cochlea; 5.8. Parotid Gland; 5.9. Larynx and Pharynx; 5.10. Lung; 5.11. Heart; 5.12. Esophagus; 5.13. Liver; 5.14. Stomach and Small Bowel; 5.15. Kidney; 5.16. Bladder; 5.17. Rectum; 5.18. Penile Bulb/Penis; 6. Imaging; Key Points; 6.1. Medical Imaging Overview; 6.2. Projectional Radiographs and Fluoroscopy6.3. Ultrasound; 6.4. Three- and Four-Dimensional Computed Tomography; 6.5. Magnetic Resonance Imaging and Spectroscopy; 6.6. Single Photon Emission Computed Tomography; 6.7. Positron Emission Tomography; 6.8. Medical Imaging Informatics; Part II: Clinical Science Concepts; 7. Clinical Epidemiology and Biostatistics; Key Points; 7.1. Evidence-Based Medicine; 7.2. Clinical Trial Design; 7.3. Clinical Trial Sample Size; 7.4. Clinical Trial Administration; 7.5. Critical Appraisal; 7.6. Cancer Clinical Trial Endpoints; 7.7. Survival Analysis; 7.8. Knowledge Translation7.9. Predictive and Prognostic Factors; 8. Cancer Epidemiology; Key Points; 8.1. Epidemiological Principles; 8.2. Incidence and Survival; 8.3. Mortality; 8.4. Predisposition and General Cancer Risk Factors; 8.5. Molecular Epidemiology and Cancer; 9. Prevention and Screening; Key Points; Key Points; 9.1. Risk Factor Avoidance; 9.2. Therapeutic Prevention Strategies; 9.3. Vaccination Prevention Strategies; 9.4. Effective Cancer Screening; 9.5. Cancer Screening Examples; 10. Cancer Staging; 10.1. Introduction; 10.2. Cancer Diagnosis and Workup; 10.3. Tumor Nodes and Metastases Staging and Grouping