Toxicity of alternatives to chlorofluorocarbons : HFC-134a and HCFC-123 / / Subcommittee to Review Toxicity of Alternatives to Chlorofluorocarbons

• Record Nr.: UNINA9910806258503321
• Pubbl/distr/stampa: Washington, D.C., : National Academy Press, : Available from [the] Committee on Human Rights, 1996
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (130 p.)
• Disciplina: 547.01046
• Soggetti: Air - Pollution; Chlorofluorocarbons - Environmental aspects
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di contenuto: ""Toxicity of Alternatives to Chlorofluorocarbons: HFC-134a and HCFC-123""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""ASSESSMENT OF MODEL FOR CARDIAC SENSITIZATION""; ""EXPOSURE GUIDANCE LEVELS FOR HFC-134A""; ""EXPOSURE GUIDANCE LEVEL FOR HCFC-123""; ""1 Introduction ""; ""STATEMENT OF TASK""; ""DEFINITIONS""; ""Emergency Exposure Guidance Level""; ""Continuous Exposure Guidance Level""; ""STRUCTURE OF THE REPORT""; ""2 Evaluation of the Dog Cardiac Sensitization Test ""; ""INTRODUCTION""; ""MECHANISM OF ACTION FOR CHEMICALLY INDUCED ARRHYTHMIAS""; ""PROTOCOL FOR A CARDIAC SENSITIZATION SCREENING STUDY""""CARDIAC SENSITIZATION EXPERIMENTS INVOLVING SELECTED HALOCARBONS""; ""CONCLUSION""; ""REFERENCES""; ""3 Exposure Guidance Levels for Hydrofluorocarbon-134a ""; ""INTRODUCTION""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""TOXICOKINETICS""; ""TOXICITY INFORMATION""; ""Acute Toxicity""; ""Cardiac Sensitization""; ""Subacute Toxicity""; ""Subchronic Toxicity""; ""Developmental Toxicity""; ""Reproductive Toxicity""; ""Genotoxicity""; ""Carcinogenicity""; ""SUMMARY""; ""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS""""REFERENCES""; ""4 Exposure Guidance Levels for ; Hydrochlorofluorocarbon-123 ""; ""INTRODUCTION""; ""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS""; ""REFERENCES""; ""Appendix A""; ""SUPPORTING DOCUMENTATION FOR THE EXPOSURE GUIDANCE LEVELS FOR HYDROCHLOROFLUOROCARBON-123""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""TOXICOKINETICS""; ""TOXICITY INFORMATION""; ""Effects in Humans""; ""Effects in Animals""; ""Single-Exposure Studies""; ""Repeat-Exposure Studies""; ""EXPOSURE ASSESSMENT""; ""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVEL""""REFERENCES""; ""ATTACHMENT 1 MATERIAL SAFETY DATA SHEET""; ""ATTACHMENT 2 HALOTHANE""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""ACUTE TOXICITY INFORMATION""; ""Acute Toxicity and CNS Depression""; ""Cardiac Sensitization""; ""Effects in Humans""; ""Malignant Hyperthermia""; ""Hepatotoxicity""; ""DISCUSSION""; ""HCFC-123 AND Halothane Comparison""; ""Acute Toxicity and CNS Depression""; ""Cardiac Sensitization""; ""Malignant Hyperthermia""; ""Hepatotoxicity""; ""REFERENCES""; ""ATTACHMENT 3 SUMMARY OF TOXICITY STUDIES OF HCFC-123""""I. ANIMAL STUDIES: SINGLE EXPOSURE""; ""II. ANIMAL STUDIES: REPEAT EXPOSURE""; ""III. REFERENCES""; ""ATTACHMENT 4 SUMMARY OF ACUTE PHARMACOKINETIC STUDY OF HCFC-123 IN DOGS BY INHALATION""; ""OBJECTIVE""; ""MATERIALS AND METHODS""; ""Exposure System""; ""Blood and Tissue Sampling""; ""Analysis of Blood and Tissue Samples""; ""RESULTS""; ""DISCUSSION""