Intro -- Contents -- Abbreviations -- 1: History and Development of Hyperbaric Medicine -- 1.1 Brief History of Hyperbaric Medicine -- 1.2 HBOT and Radiosensitization -- 1.3 Future Perspectives of HBOT in Therapeutics -- References -- 2: Physiology of Oxygen Transport and Gas Laws -- 2.1 Composition of Air -- 2.2 Gas Laws -- 2.2.1 Henry's Law -- 2.2.2 Dalton's Law -- 2.2.3 Boyle's Law -- 2.2.4 Amonton's Law/Gay-Lussac's Law -- 2.2.5 Ideal Gas Law -- 2.2.6 Fick's Law of Gas Diffusion -- 2.2.7 Adiabatic Compression of Gases and Joule-Thomson Effect -- 2.2.8 LaPlace's Law -- 2.3 Oxygen Transport in Normobaric and Oxygen-Hemoglobin Dissociation Curve -- References -- 3: Biochemical and Physiological Aspects of HBOT -- 3.1 Bohr Effect and Haldane Effect -- 3.2 Oxygen Consumption -- 3.3 Oxygen Debt -- 3.4 Oxidative Phosphorylation and Electron Transport Chain -- 3.5 Reactive Oxygen Species and Oxidative Damage -- 3.6 Physiology of Oxygen Utilization in HBOT -- 3.7 Nutraceuticals as an Accessory to HBOT -- References -- 4: Physiological Effects of Elevated Barometric Pressure -- 4.1 Effect of Increased Pressure on Physiological Functions -- 4.1.1 Effects on Hematological Functions -- 4.1.2 Changes in Cardiovascular and Skeletal System -- 4.1.3 Effect on Respiratory System -- 4.1.4 Effect of Other Atmospheric Gases on Physiological Functions -- 4.1.5 Effect on Neurological and Endocrine Functions -- 4.2 Pressure Considerations in HBOT -- References -- 5: Hyperbaric Chambers: Design and Function -- 5.1 Monoplace Chambers -- 5.1.1 Advantages of Monoplace Chambers --
5.1.2 Drawbacks -- 5.2 Multiplace Chambers -- 5.2.1 Advantages of Multiplace Chambers -- 5.2.2 Drawbacks -- 5.3 Safety Measures and Other Considerations for Hyperbaric Facility -- 5.3.1 Staffing Requirements for Hyperbaric Facility.
5.3.2 Risk Management and Risk Assessment -- 5.3.3 Procedures -- 5.3.4 Patient Safety -- 5.3.5 Fire Safety -- References -- 6: Transcutaneous Oximetry as an Assessment Tool in HBOT -- 6.1 Importance of Transcutaneous Oximetry in HBOT -- 6.2 Algorithms and Considerations in the Measurement of Transcutaneous Oxygen Tension -- References -- 7: Evaluating the Recommended Indications of HBOT -- 7.1 Air or Gas Embolism -- 7.1.1 Complications of Gas or Air Embolism -- 7.1.2 Management of air or Gas Embolism by HBOT -- 7.2 Carbon Monoxide (CO) Poisoning -- 7.2.1 HBOT as a Treatment Strategy for CO Poisoning -- 7.3 Central Retinal Artery Occlusion (CRAO) -- 7.3.1 Pathophysiology of Central Retinal Artery Occlusion (CRAO) -- 7.3.2 HBOT in Treatment of CRAO-Strategies and Clinical Evidences for its Effectiveness -- 7.4 Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) -- 7.4.1 Idiopathic Sudden Sensorineural Hearing Loss (ISSHL) -- 7.4.2 Evaluation of HBOT as a Treatment Strategy for ISSHL -- 7.5 Wound Healing -- 7.5.1 Physiology of Wound Healing -- 7.5.2 Hyperbaric Oxygen Therapy as an Adjunctive Treatment for Wound Healing -- 7.6 Arterial Insufficiency-Diabetic Foot Ulcers and Problem Wound -- 7.6.1 Problem Wounds or Non-healing Wounds -- 7.6.2 HBOT for the Treatment of Non-healing Wounds -- 7.7 Chronic Wounds -- 7.7.1 Management of Chronic Wounds -- 7.7.2 Assessment of Chronic Wound and Wound Environment -- 7.7.3 HBOT for the Management of Chronic Wounds -- 7.8 Gas Gangrene or Clostridial Myonecrosis -- 7.8.1 Etiology and Clinical Complications of Gas Gangrene -- 7.8.2 HBOT as an Adjunctive Treatment for Gas Gangrene -- 7.9 Necrotizing Soft Tissue Infections -- 7.9.1 Necrotizing Soft Tissue Infections-Complications and Treatment Strategies -- 7.9.2 Use of HBOT against Necrotizing Soft Tissue Infections.
7.10 Refractory Osteomyelitis -- 7.10.1 Refractory Osteomyelitis -- 7.10.2 Clinical Management of Refractory Osteomyelitis -- 7.10.3 Cierny-Mader Classification of Osteomyelitis -- 7.10.4 Treatment of Refractory Osteomyelitis by HBOT -- 7.11 Malignant Otitis Externa -- 7.11.1 Malignant Otitis Externa -- 7.11.2 Myringotomy as an Assessment Tool in Malignant Otitis Externa -- 7.11.3 Management of Malignant Otitis Externa by HBOT -- 7.12 Compromised Skin Grafts and Flaps -- 7.12.1 Considerations for Skin Grafts and Flaps -- 7.12.2 Wound Management on Compromised Grafts and Flaps -- 7.12.3 HBOT for Treatment of Compromised Grafts and Flaps -- 7.13 Crush Injuries -- 7.13.1 Classification of Crush Injuries and Challenges -- 7.13.2 Physiological and Biochemical Aspects of Crush Injuries -- 7.13.3 Effect of HBOT on Wound Healing in Crush Injuries -- 7.14 Severe Anemia -- 7.14.1 Clinical Scenario of Severe Blood Loss and Complications -- 7.14.2 Management of Severe Anemia by HBOT -- 7.15 Sickle Cell Anemia -- 7.15.1 Pathophysiology and Clinical Aspects of Sickle Cell Anemia -- 7.15.2 HBOT in Management of SCA -- 7.16 Decompression Sickness -- 7.16.1 Pathophysiology and Effects of Decompression Sickness -- 7.16.2 Use of HBOT as a Therapeutic in Treatment of Decompression Sickness -- 7.17 Intracranial Abscess -- 7.17.1 Pathogenic Condition and Host Defense in Intracranial Abscess -- 7.17.2 HBOT as an Adjunctive Therapy for Management of Intracranial Abscess -- 7.18 Femoral Head Necrosis -- 7.18.1 Pathogenesis and Staging of Femoral Head Necrosis -- 7.18.2 HBOT as an Aid against Femoral
Head Necrosis -- 7.19 Thermal Burns -- 7.19.1 Pathophysiology of Burn Wounds -- 7.19.2 Role of HBOT in Treatment of Thermal Burns -- 7.20 Delayed Radiation Injuries -- 7.20.1 Pathology and Complications of Delayed Radiation Injuries.
7.20.2 HBOT as an Aid in Treatment of Delayed Radiation Injuries -- 7.20.3 Marx's Protocol for Radionecrosis Treatment Using HBOT -- References -- 8: HBOT in Emergency Procedures -- 8.1 Standard and Emergency Indications for HBOT -- 8.2 Potential Benefits of HBOT in Emergency Conditions -- References -- 9: Patient Selection and Patient Care -- 9.1 Patient Evaluation Before HBOT -- 9.2 Patient Selection Criteria -- References -- 10: HBOT in Aging and Regeneration -- 10.1 Aging and Regeneration -- 10.2 HBOT as a Regenerative and Anti-Aging Therapy -- References -- 11: Oxygen Toxicity and Side Effects of HBOT -- 11.1 Oxygen Toxicity -- 11.2 Mechanism of Oxygen Toxicity -- 11.3 Physiological Manifestations of Oxygen Toxicity -- 11.4 Side Effects of HBOT -- 11.4.1 Pulmonary Barotrauma -- 11.4.2 Middle Ear Barotrauma -- 11.4.3 Sinus/Paranasal Barotrauma -- 11.4.4 Dental Barotrauma -- 11.4.5 Other Side Effects of HBOT -- 11.5 Specific Drug Interaction with HBOT -- 11.6 Effect of HBOT on Drug Mechanism -- References -- 12: Contraindications of HBOT -- 12.1 Risk Assessment of Barometric Changes -- 12.2 Risk Assessment of Oxygen Breathing Under Hyperbaric Conditions -- 12.3 General Contraindications to HBOT -- 12.3.1 Absolute Contraindications -- 12.3.2 Relative Contraindications -- 12.4 Specific Cases for Contraindications -- References.