Substance P in the nervous system

• Record Nr.: UNINA9910806162503321
• Pubbl/distr/stampa: London, : Pitman; Summit, N.J., USA, : Distributed in North America by Ciba Pharmaceutical Co., Medical Education Administration, 1982
• ISBN: 1-280-78407-5; 9786613694461; 0-470-72073-5; 0-470-71842-0
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (362 p.)
• Collana: Ciba Foundation symposium ; ; 91
• Altri autori (Persone): PorterRuth; O'ConnorMaeve
• Disciplina: 599/.0188
• Soggetti: Substance P; Neurology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "Editors: Ruth Porter (organizer) and Maeve O'Connor"--P. v.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Substance P in the nervous system; Contents; Introduction; Chemical neurotransmission-yesterday and today; Role of substance P as a sensory transmitter in spinal cord and sympathetic ganglia; Discussion; Substance P in peripheral sensory processes; Discussion; Localization of substance P in neuronal pathways; Discussion; Distribution of substance P in brain and periphery and its possible role as a co-transmitter; Discussion; Regulation of substance P expression and metabolism in vivo and in vitro; Discussion; GENERAL DISCUSSION; Coexistence of transmitters; Substance P in nerve tissue in the gut Discussion; Biosynthesis, axonal transport and turnover of neuronal substance P; Discussion; Enzymic inactivation of substance P in the central nervous system; Discussion; Substance P receptors in the nervous system and possible receptor subtypes; Discussion; Relation of substance P to pain transmission: neurophysiological evidence; Discussion; Substance P in nociceptive sensory neurons; Discussion; If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its ; function?; Discussion; Modulation of cholinergic transmission by substance PDiscussion; The striatonigral substance P pathway and dopaminergic mechanisms; Discussion; Relation of substance P to stress and catecholamine metabolism; Discussion; Behavioural effects of substance P through dopaminergic pathways in the brain; Discussion; FINAL GENERAL DISCUSSION; Substance P antagonists; tumour cell lines and substance P; substance P and other tachykinins; substance P and clinical pain syndromes; substance P and neuronal systems; Index of contributors; Subject index