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1. |
Record Nr. |
UNINA9910798411603321 |
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Autore |
Sharma Arvind |
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Titolo |
Gandhi : a spiritual biography / / Arvind Sharma |
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Pubbl/distr/stampa |
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New Haven : , : Yale University Press, , [2013] |
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©2013 |
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ISBN |
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Descrizione fisica |
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1 online resource (263 pages) |
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Disciplina |
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Soggetti |
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Statesmen - Religious life - India |
Religious leaders |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Birth and adolescence -- Child marriage -- God enters Gandhi's life -- Gandhi in London -- Gandhi and Raychand -- Gandhi's conversion experience -- Out of Africa -- Spiritual warfare -- Touching the untouchable -- Fighting fire with light -- Mahatma Gandhi and Ramana Maharshi -- Spiritual temptations -- Spiritual serendipity -- Beefing up vegetarianism -- The sex life of a celibate -- The Bhagavad Gita, Gandhi's other mother -- Gandhi, God, and goodness -- Demythologizing and analyzing Gandhi -- Gandhi's spiritual biography and contemporary history. |
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Sommario/riassunto |
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In his Autobiography, Gandhi wrote, "What I want to achieve - what I have been striving and pining to achieve these thirty years - is self-realization, to see God face to face. ... All that I do by way of speaking and writing, and all my ventures in the political field, are directed to this same end." While hundreds of biographies and histories have been written about Gandhi (1869-1948), nearly all of them have focused on the national, political, social, economic, educational, environmental, or familial dimensions of his life. Very few, in recounting how Gandhi led his country to political freedom, have viewed his struggle primarily as a search of spiritual liberation. Shifting the focus to the understudied subject of Gandhi's spiritual life, Arvind Sharma retells the story of Gandhi's life through this lens. Illuminating unsuspected dimensions of Gandhi's inner world and uncovering their surprising connections with |
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his outward actions, Sharma explores the eclectic religious atmosphere in which Gandhi was raised, his belief in karma and rebirth, his conviction that morality and religion are synonymous, his attitudes toward tyranny and freedom, and, perhaps most important, the mysterious source of his power to establish new norms of human conduct. This book enlarges our understanding of one of history's most profoundly influential figures, a man whose trust in the power of the spirit helped liberate millions. |
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2. |
Record Nr. |
UNINA9910983338303321 |
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Autore |
Aoki Keisuke |
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Titolo |
Development of Mirror-Image VHHs with Less Immunogenicity / / by Keisuke Aoki |
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Pubbl/distr/stampa |
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Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2025 |
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ISBN |
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Edizione |
[1st ed. 2025.] |
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Descrizione fisica |
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1 online resource (140 pages) |
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Collana |
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Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5061 |
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Disciplina |
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Soggetti |
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Chemistry |
Pharmacy |
Proteins |
Immunogenetics |
Chemical Synthesis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Chapter 1.Introduction -- Chapter 2.Chemical Synthesis of Mirror-Image VHHs and Evaluation of Their Immunogenicity -- Chapter 3.Identification of a Mirror-Image VHH against Vascular Endothelial Growth Factor -- Chapter 4.Synthetic Study of Full-Length Hepatitis B Virus Core Protein and Its Capsid Assembly -- Chapter 5.Chemical Synthesis of Interleukin-6 for Mirror-Image VHH Discovery -- Chapter 6.Conclusions. |
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Sommario/riassunto |
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This book outlines the chemical synthesis of therapeutic targets and a screening process for unexplored mirror-image single-domain antibodies (D-VHH). This book first describes the chemical synthesis of model VHH and the characteristics of both enantiomeric VHHs, including binding activity, biodistribution and immunogenicity. Immunogenicity testing in mice demonstrated that administration of conventional L-VHH induced the generation of anti-drug antibodies while D-VHH-binding antibodies were not observed in D-VHH-immunized mice. Second, it is explained that the T7-phage-based mirror-image screening system was developed to identify D-VHH antibody fragments capable of binding to vascular endothelial growth factors. Additionally, this book details the chemical synthesis of full-length hepatitis B virus core protein and interleukin-6 for the application of exploring D-VHHs and other mirror-image molecules. Demonstrating that it is possible to develop a D-VHH that preferentially binds the native target protein and exhibits reduced immunogenicity, this book is useful for anyone interested in developing alternative biotherapeutics with reduced immunogenicity by combining chemical and biological approaches. |
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