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Record Nr. |
UNINA9910797965603321 |
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Titolo |
Amphioxus immunity : tracing the origins of human immunity / / edited by Anlong Xu |
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Pubbl/distr/stampa |
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Amsterdam, [Netherlands] : , : Elsevier, , 2016 |
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©2016 |
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ISBN |
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Descrizione fisica |
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1 online resource (355 p.) |
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Disciplina |
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Soggetti |
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Marine invertebrates |
Marine invertebrates - Physiology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Cover; Title Page; Copyright Page; Dedication; Contents; List of contributors; About the Author; Foreword; Preface; Chapter 1 - Amphioxus as a Model for Understanding the Evolution of Vertebrates; 1.1 - Brief introduction of amphioxus; 1.2 - Biology of amphioxus; 1.2.1 - Reproduction and embryogenesis of amphioxus; 1.2.2 - Anatomy of amphioxus; 1.3 - The story of amphioxus and early research studies in China; References; Chapter 2 - Basic Knowledge of Immunology; 2.1 - Immune organs; 2.1.1 - Primary lymphoid organs; 2.1.1.1 - Bone marrow; 2.1.1.2 - Thymus; 2.1.2 - Secondary lymphoid organs |
2.1.2.1 - Lymph nodes2.1.2.2 - Spleen; 2.1.2.3 - Mucosa-associated lymphoid tissue; 2.2 - Immune cells; 2.2.1 - Lymphoid cells; 2.2.1.1 - B cells; 2.2.1.2 - T cells; 2.2.1.3 - NK cells; 2.2.2 - Innate immunity-associated cells; 2.2.2.1 - Neutrophils; 2.2.2.2 - Macrophages; 2.2.2.3 - Dendritic cells; 2.3 - Innate immunity; 2.3.1 - Toll-like receptors involved in the signaling pathway; 2.3.2 - NOD-like receptors and their functions; 2.3.3 - RIG-like receptors; 2.3.4 - C-type lectins; 2.3.5 - The scavenger receptors; 2.3.6 - Inflammation; 2.4 - Adaptive immunity; 2.4.1 - Specificity |
2.4.2 - Diversity2.4.3 - Immunological memory; 2.4.4 - Self-nonself recognition; 2.5 - Complement system; 2.5.1 - Complement pathways; 2.5.1.1 - Classical pathway; 2.5.1.2 - Lectin pathway; 2.5.1.3 - |
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Alternative pathway; 2.5.2 - Complement in host defense; References; Chapter 3 - Immune Organs and Cells of Amphioxus; 3.1 - Introduction; 3.2 - Organs of the amphioxus immune system; 3.2.1 - Amphioxus gill slits: the first immune defense line; 3.2.2 - Amphioxus intestine: not just a digestive organ but also an immune organ; 3.3 - Cells of the amphioxus immune system; 3.3.1 - Phagocytes |
3.3.2 - Lymphocyte-like cellsReferences; Chapter 4 - Genomic and Transcriptomic View of Amphioxus Immunity; 4.1 - Introduction; 4.2 - Trace evidence of adaptive immunity; 4.2.1 - TCRs, Igs, VLRs, and the origins of RAG; 4.2.2 - MHC and genes involved in antigen presentation; 4.3 - Extraordinary gene expansion in amphioxus innate immunity; 4.3.1 - The TLR system; 4.3.2 - The NLR system; 4.3.3 - LRRIG proteins; 4.3.4 - Other LRR-containing genes; 4.3.5 - C-type lectins; 4.3.6 - Scavenger receptors; 4.3.7 - RIG-I-like helicases; 4.3.8 - Complement-related receptors; 4.3.9 - The TNF system |
4.3.10 - Expansion and reshuffling of the death-fold domains4.3.11 - Expansion of TIR adaptors, TRAFs, and initiator caspases; 4.3.12 - Cytokines, kinases, and transcription factors; 4.4 - Regulation of the amphioxus immune system; 4.4.1 - Differential regulatory patterns between expanded gene families; 4.4.2 - The regulation during bacterial infection; 4.4.3 - The regulation of the terminal signaling network; 4.4.4 - Differential expression patterns observed within TNF and IL-1R systems; 4.4.5 - Major pathways in a complex signaling network; 4.4.6 - A functional prototypic complement system |
4.4.7 - The prototype of the oxidative burst-like system |
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2. |
Record Nr. |
UNINA9910767519203321 |
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Autore |
Grünig Rudolf |
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Titolo |
Successful Decision-Making : A Systematic Approach to Complex Problems / / by Rudolf Grünig, Richard Kühn |
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Pubbl/distr/stampa |
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Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2013 |
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ISBN |
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Edizione |
[3rd ed. 2013.] |
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Descrizione fisica |
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1 online resource (270 p.) |
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Disciplina |
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Soggetti |
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Leadership |
Operations research |
Decision making |
Business Strategy/Leadership |
Operations Research/Decision Theory |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction -- Decision Problems and Decision-making Procedures: Decision Problems -- Goal and Problem-finding Systems as Requirements for the Discovery of Decision Problems -- Rational Decision-making -- Decision-making Procedures -- A General Heuristic Decision-making Procedure: Overview of the Decision-making Procedure -- Problem Verification and Analysis -- Developing and Evaluating the Solution Options -- Decision Maxims for Establishing the Overall Consequences of the Options -- Overall Evaluation of the Option and Decision -- A Case Study Illustrating the Application of the Procedure -- Special Problems and Approaches to Solve Them: Decision Sequences -- Information Procurement Decisions -- Collective Decisions -- Final Remarks. |
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Sommario/riassunto |
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Making decisions is certainly the most important task of a manager and it is often a very difficult one. This book offers a decision making procedure for solving complex problems step by step. Unlike other texts, the book focuses on problem analysis, on developing solution options and on establishing the decision making matrix. The book is |
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intended for decision makers in companies, in non-profit organisations and in public administration. It is an approach to helping them to solve complex problems successfully. The book is also addressed to students and to participants in executive courses. |
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