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1. |
Record Nr. |
UNINA9910797741603321 |
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Autore |
Tyner James A. <1966-> |
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Titolo |
Violence in capitalism : devaluing life in an age of responsibility / / James A. Tyner |
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Pubbl/distr/stampa |
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Lincoln, [Nebraska] ; ; London, [England] : , : University of Nebraska Press, , 2016 |
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©2016 |
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ISBN |
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0-8032-8456-X |
0-8032-8458-6 |
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Descrizione fisica |
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1 online resource (270 p.) |
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Classificazione |
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Disciplina |
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Soggetti |
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Violence |
Violent crimes - Social aspects |
Crime - Sociological aspects |
Capitalism - Social aspects |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover ; Title Page ; Copyright Page ; Contents ; Acknowledgments; 1. The Abstraction of Violence; 2. Materialism and Mode of Production; 3. The Market Logics of Letting Die; 4. The Violence of Redundancy; 5. The Reality of Violence; Notes; Bibliography; Index |
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Sommario/riassunto |
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"A geographic reckoning with violence through case studies of how violence affects the dispossessed, women, children, workers, and the environment"-- |
"What, James Tyner asks, separates the murder of a runaway youth from the death of a father denied a bone-marrow transplant because of budget cuts? Moving beyond our culture's reductive emphasis on whether a given act of violence is intentional--and may therefore count as deliberate murder--Tyner interrogates the broader forces that produce violence. His uniquely geographic perspective considers where violence takes place (the workplace, the home, the prison, etc.) and how violence moves across space. Approaching violence as one of several methods of constituting space, Tyner examines everything from the way police departments map crime to the emergence of |
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"environmental criminology." Throughout, he casts violence in broad terms--as a realm that is not limited to criminal acts, and one that can be divided into the categories "killing" and "letting die." His framework extends the study of biopolitics by examining the state's role in producing (or failing to produce) a healthy citizenry. It also adds to the new literature on capitalism by articulating the interconnections between violence and political economy. Simply put, capitalism (especially its neoliberal and neoconservative variants) is structured around a valuation of life that fosters a particular abstraction of violence and crime"-- |
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2. |
Record Nr. |
UNINA9910781059203321 |
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Titolo |
Formal ontologies meet industry [[electronic resource] /] / edited by Roberta Ferrario and Alessandro Oltramari |
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Pubbl/distr/stampa |
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Amsterdam ; ; Washington, DC, : IOS Press, c2009 |
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ISBN |
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6612454636 |
1-282-45463-3 |
9786612454639 |
1-60750-458-8 |
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Descrizione fisica |
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1 online resource (144 p.) |
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Collana |
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Frontiers in artificial intelligence and applications, , 0922-6389 ; ; v. 198 |
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Altri autori (Persone) |
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FerrarioRoberta |
OltramariAlessandro |
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Disciplina |
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Soggetti |
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Business networks |
Information modeling |
Ontologies (Information retrieval) |
Semantic networks (Information theory) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Title page; Proceedings of FOMI 2009 -- Preface; Contents; From Data to Knowledge, the Role of Formal Ontology; Towards an Approach for |
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Evolving Information Systems' Ontologies; A First-Order Cutting Process Ontology for Sheet Metal Parts; Parts, Compositions and Decompositions of Functions in Engineering Ontologies; Towards an Ontology Infrastructure for Electromagnetism; Ontological Representation for Algerian Enterprise Modeling; Modular Ontologies for Architectural Design; Ontology-Strength Industry Standards -- The Case of the Telecommunication Domain; Disentangling Knowledge Objects |
Do You Still Want to Vote for Your Favorite Politician? Ask Ontobella!Supporting the Development of Medical Ontologies; Subject Index; Author Index |
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Sommario/riassunto |
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A collection of papers addressing the multi-shaped character of knowledge, studies and applications in the field of ontology and semantic technology. |
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3. |
Record Nr. |
UNINA9910346749903321 |
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Autore |
Kristijan Ramadan |
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Titolo |
Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (183 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the deleterious consequences of DNA damage. It is estimated that every single cell receives tens of thousands of DNA lesions per day. Failure of DDR to properly respond to DNA damage leads to stem cell dysfunction, accelerated ageing, various degenerative diseases or cancer. The sole function of DDR is to recognize diverse |
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DNA lesions, signal their presence, activate cell cycle arrest and finally recruit specific DNA repair proteins to fix the DNA damage and thus prevent genomic instability. DDR is composed of hundreds of spatiotemporally regulated and interconnected proteins, which are able to promptly respond to various DNA lesions. So it is not surprising that mutations in genes encoding various DDR proteins cause embryonic lethality, malignancies, neurodegenerative diseases and premature ageing. The importance of DDR for cell survival and genome stability is unquestionable, but how the sophisticated network of hundreds of different DDR proteins is spatiotemporally coordinated is far from being understood. In the last ten years ubiquitin (ubiquitination) and the ubiquitin-relative SUMO (sumoylation) have emerged as essential posttranslational modifications that regulate DDR. Beside a plethora of ubiqutin and sumo E1-activating enzymes, E2-conjugating enzymes, E3-ligases and ubiquitin/sumo proteases involved in ubiquitination and sumoylation, the complexity of ubiqutin and sumo systems is additionally increased by the fact that both ubiquitin and sumo can form a variety of different chains on substrates which govern the substrate fate, such as its interaction with other proteins, changing its enzymatic activity or promoting substrate degradation. The importance of ubiquitin/SUMO systems in the orchestration of DDR is best illustrated in patients with mutations in E3-ubiquitin ligases BRCA1 or RNF168. BRCA1 is essential for proper function of DDR and its mutations lead to triple-negative breast and ovarian cancers. RNF168 is an E3 ubiquitin ligase, which creates the ubiquitin docking platform for recruitment of different DNA damage signalling and repair proteins at sites of DNA lesion, and its mutations cause RIDDLE syndrome characterized by radiosensitivity, immunodeficiency and learning disability. In addition, recently discovered the ubiquitin receptor protein SPRTN is part of the DNA replication machinery and its mutations cause early-onset hepatocellular carcinoma and premature ageing in humans. Despite more than 700 different enzymes directly involved in ubiquitination and sumoylation processes only few of them are known to play a role in DDR. Therefore, we feel that the role of ubiquitin and the ubiquitin-related SUMO in DDR is far from being understood, and that this is the emerging field that will hugely expand in the next decade due to the rapid development of a new generation of technologies, which will allow us a more robust and precise analyses of human genome, transcriptome and proteome. In this Research Topic we provide a comprehensive overview of our current understanding of ubiquitin and SUMO pathways in all aspects of DDR, from DNA replication to different DNA repair pathways, and demonstrate how alterations in these pathways cause genomic instability that is linked to degenerative diseases, cancer and pathological ageing. |
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