Mechanism of the anticancer effect of phytochemicals / / edited by S. Zahra Bathaie, Department of Clinical Biochemistry, Tarbiat Modares University Tehran, Iran, Fuyuhiko Tamanoi, Department of Microbiology, Immunology and Molecular Genetics Jonsson Comprehensive Cancer Center Molecular Biology Institue University of California Los Angeles, California, USA

• Record Nr.: UNINA9910797589003321
• Pubbl/distr/stampa: Waltham, MA : , : Elsevier Science, , 2015
• ISBN: 0-12-803877-2; 0-12-803876-4
• Edizione: [First edition.]
• Descrizione fisica: 1 online resource (285 p.)
• Collana: Enzymes, , 1874-6047 ; ; volume 37
• Disciplina: 616.994061
• Soggetti: Cancer - Chemoprevention; Cancer - Diet therapy; Phytochemicals - Therapeutic use
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: Front Cover; Mechanism of the Anticancer Effect of Phytochemicals; Copyright; Contents; Contributors; Preface; Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?; 1. Introduction; 2. Phytochemicals Application in Chemoprevention Strategies; 2.1. Blocking Initiation/Reversing Promotion; 2.2. Activating Phase II Detoxifying Enzymes; 2.3. Prooxidant/Antioxidant Activities; 2.4. Protection Against Radiation; 2.5. Alteration in Signaling Pathways; 2.6. Effect on Cell-Cell Adhesion Machinery; 2.7. Induction of Epigenetic Changes; 3. Phytochemicals Usage as Chemotherapeutic3.1. Inhibition of Enzymes; 3.1.1. Inhibition of Topoisomerases I or II; 3.1.2. Effect on Telomerase; 3.1.3. Other Enzymes; 3.2. Direct Binding to Biomacromolecules; 3.3. Epigenetic Alteration/Chromatin Modification; 3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation; 3.3.2. DNA Methylation Status; 3.4. RNA Modulation; 3.5. Autophagy and UPR68; 3.6. Apoptosis Induction; 3.7. Cell Cycle Arrest; 3.8. Inhibiting Angiogenesis; 3.9. ; Adjuvant/Combinatorial Therapy; 4. Summary; References; Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions1. Introduction; 2. Quercetin; 2.1. Source; 2.2. Biosynthesis; 2.3. Structure and Antioxidative Property; 2.4. Properties; 2.4.1. Antioxidant Property; 2.4.2. Free Radical Scavenging Activity; 2.4.3. Nitric Oxide Inhibitory Action; 2.4.4. Inhibition of Xanthine Oxidase; 2.4.5. Interaction with Other Enzyme Systems; 2.5. Pharmacokinetics; 2.6. Role as an Anticancer Agent; 2.6.1. Cell Cycle Regulation; 2.6.2. Quercetinś Effect on Apoptosis; 2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness2.7. Quercetinś Role as an Anti-Inflammatory Agent; 2.8. Quercetinś Influence on p53; 2.9. Quercetinś Nontoxicity Against Normal Cells; 2.10. Quercetinś Action Against Chemical-Induced Tumor and Xenograft; 2.11. Synergism with Other Drugs; 2.12. Clinical Study; 3. Tryptanthrin; 3.1. Chemistry; 3.2. Source; 3.3. Medicinal Value; 3.4. Cytotoxic and Anticancer Properties of Tryptanthrin; 3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity; 3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events3.6.1. Antioxidant Activity; 3.6.2. Anti-Inflammatory Activity; 3.7. Angiogenesis; 3.8. Toxicological Analysis; 4. Conclusion; Acknowledgement; References; Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides; 1. Introduction; 2. Reactive Oxygen Species Signaling; 3. Cytoskeletal Organizing and Structural Proteins; 4. Proteasomal Inhibition; 5. Inhibition of Mitosis; 6. Transcription Factors; 7. Heat Shock Proteins; 8. Metabolic Enzymes; 9. Synergistic Action; References
• Sommario/riassunto: Volume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of the Enzyme series was on the topic of Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field

Hispanic health : problems with coverage, access, and health disparities : hearing before the Subcommittee on Public Health of the Committee on Health, Education, Labor, and Pensions, United States Senate, One Hundred Seventh Congress, second session, on examining Hispanic health problems, focusing on coverage, access, and health disparities, September 23, 2002

• Record Nr.: UNINA9910689699003321
• Descrizione fisica: 1 online resource (iii, 80 p.)
• Soggetti: Hispanic Americans - Medical care; Hispanic Americans - Health and hygiene; Health insurance - United States; Health services accessibility - United States
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia

Disease management and coordinating care : what role can they plan [i.e. play] in improving the quality of life for Medicare's most vulnerable? : hearing before the Special Committee on Aging, United States Senate, One Hundred Seventh Congress, second session, Washington, DC, September 19, 2002

• Record Nr.: UNINA9910689700603321
• Descrizione fisica: 1 online resource (iii, 94 p.) : ill
• Soggetti: Disease management - United States; Older people - Long-term care - United States; Chronically ill - Care - United States; Health planning - United States; Medicare
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia

1956 Supplement to the Bibliography and Abstracts on Electrical Contacts

• Record Nr.: UNINA9910164740303321
• Autore: Shobert Erle I., II (Erle Irwin), <1913-2001, >
• Pubbl/distr/stampa: [Place of publication not identified], : American Society for Testing & Materials, 1957
• ISBN: 0-8031-6769-5
• Descrizione fisica: 1 online resource : illustrations
• Disciplina: 621.3
• Soggetti: Electric contacts
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di bibliografia: Includes bibliographical references and indexes.