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Record Nr. |
UNINA9910797252503321 |
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Titolo |
Peptide and protein vaccines / / edited by Rossen Donev |
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Pubbl/distr/stampa |
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Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
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©2015 |
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ISBN |
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0-12-802869-6 |
0-12-802827-0 |
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Descrizione fisica |
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1 online resource (192 p.) |
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Collana |
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Advances in Protein Chemistry and Structural Biology, , 1876-1623 ; ; Volume 99 |
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Disciplina |
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Soggetti |
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Peptides - Therapeutic use |
Proteins - Therapeutic use |
Peptide drugs |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and indexes. |
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Nota di contenuto |
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Front Cover; Peptide and Protein Vaccines; Copyright; Contents; Contributors; Preface; References; Chapter 1: Peptide Immunotherapy in Vaccine Development: From Epitope to Adjuvant; 1. Introduction; 2. Cancer Vaccine; 3. Allergy Vaccine; 4. Alzheimerś Disease Vaccine; 5. Adjuvant and Delivery; 6. Perspectives and Conclusions; References; Chapter 2: The Use of Liposomes to Shape Epitope Structure and Modulate Immunogenic Responses of Peptide Vaccines Against...; 1. Introduction; 2. MPER: ASite of Vulnerability on HIV-1 Env and a Linear Epitope; 3. Structural Organization of MPER |
3.1. Hydrophobicity Distribution3.2. MPER Peptide Structure; 4. Lipid Vesicles: Adjuvants and Devices to Shape MPER Structure; 4.1. Liposomes as Adjuvants; 4.2. The Lipid Bilayer as an MPER Scaffold; 5. Immunogenicity Studies of MPER-Derived Peptides in Liposomes; References; Chapter 3: Recombinant Lipoproteins as Novel Vaccines with Intrinsic Adjuvant; 1. Introduction; 2. Establishment of High Expression Recombinant Lipoprotein System; 3. The Lipid Structure of Lipoprotein; 4. Recombinant Lipoprotein with Intrinsic Adjuvant Properties |
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5. To Engineer Chimeric Lipoproteins with Intrinsic Adjuvant for Novel Vaccine Development6. Recombinant Chimeric Lipoproteins Can Activate BMDCs; 7. A Robustness Up- and Downstream Processes for Lipoprotein Production; 8. Recombinant Lipoprotein-Based Subunit Vaccine Induces High Titers of Neutralizing Antibody and Longer Memory Immune Re...; 9. Recombinant Lipidated Human Papillomavirus E7 Induces Cellular Immune Responses and Protective Immunity Against Cervic...; 10. Conclusion; Acknowledgment; References |
Chapter 4: Perspective of Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers1. Introduction; 2. Licensed Adjuvants; 3. CpG-DNA: Adjuvant; 4. Phosphodiester Bond CpG-DNA; 5. Liposomes: Adjuvants; 6. Adjuvants for Peptide Vaccine; 7. Peptide Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.1. Antibody Production with Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers; 7.2. Prevention of Influenza A Virus Infection; 7.3. Prevention of Respiratory Syncytial Virus Infection |
7.4. Cancer Vaccine Composed of Epitope Peptide, CpG-DNA, and Liposome Complex Without Carriers8. Perspectives; Acknowledgments; References; Chapter 5: Chemical Platforms for Peptide Vaccine Constructs; 1. Introduction; 2. Multiple Antigenic Peptide System Using a PolyLys Core: ABoon to Synthetic Peptide Vaccines; 3. Synthetic Antigen Carrier Bearing N-(S-acetylmercaptoacetyl)-Glutamyl Residues; 4. Thioester as a Replacement for Natural Peptide Bond (Chemical Ligation): Construction of Proteins; 5. Synthetic Peptide Dendrimer with Thiazolidinyl Pendant |
6. Oxime Chemistry for Synthetic Peptide-Based Vaccines |
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Sommario/riassunto |
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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in a wide bioscience areaChapters are written by authorities in their fieldTargeted to a wide audience of researchers, specialists, and studentsThe information provided in the volume is well s |
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