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1. |
Record Nr. |
UNINA9910796964103321 |
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Titolo |
Positioning the self and others : linguistic perspectives / / edited by Kate Beeching, Chiara Ghezzi, Piera Molinelli |
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Pubbl/distr/stampa |
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Amsterdam ; ; Philadelphia : , : John Benjamins Publishing Company, , [2018] |
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©2018 |
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Descrizione fisica |
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1 online resource (324 pages) |
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Collana |
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Pragmatics & beyond new series ; ; Volume 292 |
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Disciplina |
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Soggetti |
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Sociolinguistics |
Identity (Psychology) |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and indexes. |
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Nota di contenuto |
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Positioning through address practice in Finland-Swedish and Sweden-Swedish service encounters / Catrin Norrby, Camilla Wide, Jenny Nilsson and Jan Lindström -- Sociocultural and linguistic constraints in address choice from Latin to Italian / Piera Molinelli -- Closeness at a distance: Positioning in Brazilian workplace emails / Carolin Debray and Sophie Reissner-Roubicek -- Beyond the notion of periphery: An account of polyfunctional discourse markers within the Val.Es.Co. model of discourse segmentation / Shima Salameh Jiménez, Maria Estellés Arguedas and Salvador Pons Bordería -- Metacommenting in English and French: A variational pragmatics approach / Kate Beeching -- Direct speech, subjectivity and speaker positioning in London English and Paris French / Maria Secova -- Positioning of self in interaction: Adolescents' use of attention-getters / Karin Aijmer -- Constellation of indexicalities and social meaning: The evolution of cioè in Contemporary Italian / Chiara Ghezzi -- "Proper is whatever people make it": Stance, positionality, and ideological packaging in a dinnertime conversation / Mary-Caitlyn Valentinsson -- Representations of self and other in narratives of return migration / Alexander Nikolaou and Jennifer Sclafani -- Orthography as an identity marker: The case of bilingual road signs in the province of Bergamo / Federica Guerini -- Positioning the self in talk about groups: Linguistic |
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means emphasising veracity used by members of the Georgian Greek community / Concha Maria Höfler. |
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2. |
Record Nr. |
UNINA9910813330403321 |
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Titolo |
Protein aggregation in bacteria : functional and structural properties of inclusion bodies in bacterial cells / / edited by Silvia Maria Doglia, Marina Lotti |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley, , 2014 |
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©2014 |
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ISBN |
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1-118-84536-6 |
1-118-85503-5 |
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Descrizione fisica |
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1 online resource (300 p.) |
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Collana |
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Wiley Series in Protein and Peptide Science |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells; Copyright; Contents; Contributors; Preface ; Introduction to the WileySeries in Protein and PeptideScience; 1 Fundamentals of Protein Folding ; 1.1 Folding-misfolding-nonfolding crossroads; 1.2 Protein folding; 1.2.1 Protein-Folding Code; 1.2.2 Protein-Folding Models; 1.2.3 Polymer Aspects of Protein Folding; 1.2.4 Different Conformations Seen in Protein Folding; 1.3 Nonfolding; 1.3.1 Intrinsically Disordered Proteins and Their Abundance; 1.3.2 Some Functional Advantages of IDPs |
1.3.3 Function-Induced Folding of IDPs1.3.4 IDPs and Human Diseases; 1.3.5 How Does an Amino Acid Sequence Encode Intrinsic Disorder?; 1.3.6 Polymer Aspects of Nonfolding; 1.4 Misfolding; 1.4.1 Molecular Mechanisms of Protein Misfolding; 1.4.2 Fibrillogenesis of Globular Proteins: Requirement for Partial Unfolding; 1.4.3 Fibrillogenesis of IDPs: Requirement for Partial Folding; 1.4.4 Conformational Prerequisites for Amyloidogenesis; 1.4.5 Multiple Pathways of Protein Misfolding; 1.4.6 Polymer Aspects of Protein Misfolding; References |
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2 Recruiting Unfolding Chaperones to Solubilize Misfolded Recombinant Proteins 2.1 Introduction; 2.2 Chemical Chaperones; 2.3 PPIs and PDIs are folding enzymes; 2.4 Molecular Chaperones; 2.5 The small Hsps; 2.6 Hsp90 ; 2.7 Hsp70/Hsp40; 2.8 GroEL Chaperonins; 2.9 Conclusions; References; 3 Osmolytes as Chemical Chaperones to Use in Protein Biotechnology ; 3.1 Introduction; 3.2 Protein-destabilizing conditions and counteracting mechanisms: shared or independent routes?; 3.3 Proposed molecular mechanisms for osmolyte activities; 3.4 Osmolytes and expression of recombinant proteins |
3.5 Biotechnological relevance of osmolytes for preserving purified proteins3.6 Conclusions; References; 4 Inclusion Bodies in the Study of Amyloid Aggregation ; 4.1 Introduction; 4.2 Structure of IBs ; 4.2.1 Amyloid-like Nature of IBs ; 4.2.2 Detection and Characterization of Amyloid Conformations Inside IBs ; 4.3 Formation of IBs ; 4.3.1 In Vivo Formation Kinetics; 4.3.2 Molecular Determinants of IB Aggregation; 4.3.3 Sequence Specificity in IB Formation; 4.4 IBs as the simplest model for in vivo amyloid toxicity; 4.4.1 The Fitness Cost of Amyloid Aggregation |
4.4.2 Citotoxicity of Amyloid IBs 4.4.3 Infectious Properties of IBs ; 4.5 Using IBs to screen for amyloid inhibitors; 4.6 Conclusions; References; 5 Protein Aggregation in Unicellular Eukaryotes ; 5.1 Introduction; 5.2 UPR: Unfolded protein response in the ER; 5.3 Removing persistent misfolded proteins with the proteasome; 5.4 Lysosomal/vacuolar proteolysis (overload UPS); 5.4.1 Autophagy; 5.4.2 Selective Types of Autophagy; 5.5 Refolding of protein aggregates in cytosol and nucleus; 5.6 JUNQ and IPOD; 5.7 Segregation of aggregates in yeast |
5.8 Proteins forming nonpathological amyloid-like fibrils in unicellular eukaryotes |
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Sommario/riassunto |
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This book focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies. Recent reports revolutionized the current view of inclusion bodies from that of inert deposits of inactive proteins to reservoirs of proteins that can eventually maintain biological activity and/or be rescued by cells. Aggregation is put in the context of updated knowledge about the folding and aggregation of proteins in simple cells and new perspectives derived from the application of this knowledge are presented. The following topics are addressed: a) molecular and c |
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