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1. |
Record Nr. |
UNINA9910140501703321 |
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Titolo |
Vaccine development and manufacturing / / edited by Emily P. Wen, Ronald Ellis, Narahari S. Pujar ; Michel Chartrain [and thirty one others], contributors |
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Pubbl/distr/stampa |
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Hoboken, New Jersey : , : Wiley, , 2015 |
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©2015 |
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ISBN |
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1-78684-221-1 |
1-118-87090-5 |
1-118-87091-3 |
1-118-87092-1 |
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Descrizione fisica |
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1 online resource (1044 p.) |
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Collana |
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Wiley Series in Biotechnology and Bioengineering |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Cover; Series; Title Page; Copyright; Acknowledgments; Preface; Contributors; Chapter 1: History of Vaccine Process Development; 1.1 Introduction; 1.2 Vaccines Bioprocess Evolution; 1.3 Live Attenuated and Inactivated Virus Vaccines; 1.4 Live or Whole-Killed Bacterial Vaccines; 1.5 Classical Subunit Vaccines; 1.6 Recombinant Subunit Vaccines; 1.7 Conjugate Vaccines; 1.8 Downstream Processing; 1.9 Vaccines for the Developing World: Large Volume, Low Cost, and Thermostable; 1.10 Summary; Acknowledgments; References |
Chapter 2: The Production of Plasmid DNA Vaccine in Escherichia coli: A Novel Bacterial-Based Vaccine Production Platform2.1 Introduction: E. coli in Vaccine Production; 2.2 Brief Overview of DNA Vaccines: Mechanisms and Methods of Vaccinations; 2.3 Current Status of DNA Vaccines; 2.4 Required Physical Properties of Plasmid DNA Vaccines; 2.5 Choice of E. coli Host Strain; 2.6 Factors Influencing Plasmid Stability; 2.7 Transformation, Selection of Producing Clones, and Cell Banking; 2.8 Production Process; 2.9 Requirements for Clinical Supplies; 2.10 Conclusions; References |
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Chapter 3: Fungal Expression Systems for Vaccine Production3.1 Introduction; 3.2 Hepatitis B Vaccines; 3.3 Human Papillomavirus Vaccine; 3.4 Malaria Vaccine Candidates; 3.5 HIV Vaccine Candidates; 3.6 Veterinary Vaccines; 3.7 Perspectives; 3.8 Concluding Remarks; Acknowledgments; References; Chapter 4: Novel Expression Systems for Vaccine Production; 4.1 Introduction; 4.2 Subunit Vaccines; 4.3 Expression Systems; 4.4 Novel Expression Systems; 4.5 Production of Recombinant Proteins in Plants; 4.6 Launch Vector System; 4.7 Conclusions; References; Chapter 5: Viral Vaccines Purification |
5.1 Introduction5.2 Process Tasks; 5.3 Conclusions and Outlook; Acknowledgments; Nomenclature; Abbreviations; References; Chapter 6: Protein Subunit Vaccine Purification; 6.1 Introduction; 6.2 Purification Technologies-Applications in Protein Subunit Vaccine Purification; 6.3 Purification Process Development and Scale-Up for Protein Subunit Vaccine; 6.4 Process Definition Studies; 6.5 Process Economy and Automation; 6.6 Application of Process Analytical Technology in Protein Purification; 6.7 Downstream Purification-An Outlook; References; Chapter 7: Conjugate Vaccine Production Technology |
7.1 Conjugate Vaccine Production Technology7.2 Preparation of Antigen and Carrier Protein; 7.3 Polysaccharide Size; 7.4 Activation and Coupling of Polysaccharide and Carrier Protein; 7.5 Characterization of the Conjugate; 7.6 Future Directions; References; Chapter 8: Stabilization and Formulation of Vaccines; 8.1 Introduction; 8.2 An Example of a Modern Vaccine Characterization Strategy; 8.3 A Comprehensive Approach to Vaccine Formulation in Practice; 8.4 Conclusions; References; Chapter 9: Lyophilization In Vaccine Processes; 9.1 Introduction; 9.2 Formulation; 9.3 Filling; 9.4 Lyophilization |
9.5 Equipment |
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Sommario/riassunto |
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Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high |
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2. |
Record Nr. |
UNINA9910793467303321 |
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Autore |
Kosseff Jeff <1978-> |
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Titolo |
The twenty-six words that created the Internet / / Jeff Kosseff |
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Pubbl/distr/stampa |
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Ithaca ; ; London : , : Cornell University Press, , 2019 |
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ISBN |
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Descrizione fisica |
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1 online resource (326 pages) |
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Disciplina |
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Soggetti |
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Internet - Law and legislation - United States |
Web sites - Law and legislation - United States |
Liability (Law) - United States |
Freedom of speech - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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The creation of Section 230 -- The rise of Section 230 -- The gradual erosion of Section 230 -- The future of Section 230. |
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Sommario/riassunto |
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"No provider or user of an interactive computer service shall be treated as the publisher or speaker of any information provided by another information content provider. "Did you know that these twenty-six words are responsible for much of America's multibillion-dollar online industry? What we can and cannot write, say, and do online is based on just one law-a law that protects online services from lawsuits based on user content. Jeff Kosseff exposes the workings of Section 230 of the Communications Decency Act, which has lived mostly in the shadows since its enshrinement in 1996. Because many segments of American society now exist largely online, Kosseff argues that we need to understand and pay attention to what Section 230 really means and how it affects what we like, share, and comment upon every day. The Twenty-Six Words That Created the Internet tells the story of the institutions that flourished as a result of this powerful statute. It introduces us to those who created the law, those who advocated for it, and those involved in some of the most prominent cases decided under the law. Kosseff assesses the law that has facilitated freedom of online speech, trolling, and much more. His keen eye for the law, combined with his background as an award-winning journalist, demystifies a |
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statute that affects all our lives -for good and for ill. While Section 230 may be imperfect and in need of refinement, Kosseff maintains that it is necessary to foster free speech and innovation. For filings from many of the cases discussed in the book and updates about Section 230, visit jeffkosseff.com |
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