1.

Record Nr.

UNINA9910792788603321

Autore

Winston Sally M.

Titolo

Overcoming unwanted intrusive thoughts : a CBT-based guide to getting over frightening, obsessive, or disturbing thoughts / / Sally M. Winston, PsyD, Martin N. Seif, PhD

Pubbl/distr/stampa

Oakland, CA : , : New Harbinger Publications, Inc., , [2017]

Distributed in Canada by Raincoast Books.

©2017

ISBN

9781626254350

1626254354

9781626254343

1626254346

Descrizione fisica

1 online resource (180 pages, 13 unnumbered pages) : illustrations

Disciplina

616.8

Soggetti

Intrusive thoughts

Thought insertion

Cognition disorders

Cognitive therapy

Anxiety disorders

Interference (Perception)

Anxiety

Cognitive Disorders

Cognitive Therapy

Stress, Psychological

Thinking

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"Distributed in Canada by Raincoast Books"--Title page verso.

Nota di bibliografia

Includes bibliographical references (pages 179-180).

Nota di contenuto

Recovering from unwanted intrusive thoughts -- Varieties of intrusive thoughts -- What thoughts mean: myths and facts -- Unwanted intrusive thoughts Q and A -- How the brain creates unwanted intrusive thoughts -- Why nothing has worked -- How to handle thoughts when they happen -- Getting over unwanted thoughts for



good -- What does recovery mean? -- When to seek professional help -- Appendix: A recipe for unwanted intrusive thoughts (what not to do).

Sommario/riassunto

"You are not your thoughts! In this powerful book, two anxiety experts offer proven-effective cognitive behavioral therapy (CBT) skills to help you get unstuck from disturbing thoughts, overcome the shame these thoughts can bring, and reduce your anxiety. If you suffer from unwanted, intrusive, frightening, or even disturbing thoughts, you might worry about what these thoughts mean about you. Thoughts can seem like messages--are they trying to tell you something? But the truth is that they are just thoughts, and don't necessarily mean anything. Sane and good people have them. If you are someone who is plagued by thoughts you don't want--thoughts that scare you, or thoughts you can't tell anyone about--this book may change your life. In this compassionate guide, you'll discover the different kinds of disturbing thoughts, myths that surround your thoughts, and how your brain has a tendency to get "stuck" in a cycle of unwanted rumination. You'll also learn why common techniques to get rid of these thoughts can backfire. And finally, you'll learn powerful cognitive behavioral skills to help you cope with and move beyond your thoughts, so you can focus on living the life you want. Your thoughts will still occur, but you will be better able to cope with them--without dread, guilt, or shame. If you have unwanted thoughts, you should remember that you aren't alone. In fact, there are millions of people just like you--good people who have awful thoughts, gentle people with violent thoughts, and sane people with "crazy" thoughts. This book will show you how to move past your thoughts so you can reclaim your life! This book has been selected as an Association for Behavioral and Cognitive Therapies Self-Help Book Recommendation--an honor bestowed on outstanding self-help books that are consistent with cognitive behavioral therapy (CBT) principles and that incorporate scientifically tested strategies for overcoming mental health difficulties. Used alone or in conjunction with therapy, our books offer powerful tools readers can use to jump-start changes in their lives."--Provided by publisher.



2.

Record Nr.

UNINA9910809059703321

Autore

Schmiedel Jörn Matthias <1985->

Titolo

The role of microRNAs in controlling protein expression noise / / von Diplom Biophysiker Jörn Matthias Schmiedel

Pubbl/distr/stampa

Berlin : , : Logos Verlag Berlin, , [2016]

©2016

ISBN

3-8325-8802-7

Descrizione fisica

1 online resource (116 pages) : illustrations

Disciplina

572.865

Soggetti

Gene expression

MicroRNA

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

PublicationDate: 20160331

Nota di bibliografia

Includes bibliographical references (pages 103-114).

Sommario/riassunto

Long description: The expression of genes is based on stochastic processes, which lead to temporal fluctuations in the number of proteins of each gene. If such fluctuations become too large they can be detrimental to the fitness of an organisms, because most cellular processes are based on the precise interaction of proteins.   This PhD thesis explores the role of post-transcriptional regulatory mechanisms in the control of stochasticity in gene expression, with a focus on microRNAs, common regulators in multicellular organisms. Bioinformatic data analysis, mathematical modeling and single cell expression experiments are used to analyze the conditions under which microRNAs can lead to the reduction of fluctuations in gene expression. The central insight of this thesis is that microRNAs can indeed reduce fluctuations for most genes and that they are likely used by organisms for this purpose, thus ensuring precision to gene expression during development and the maintenance of the adult body.  Der Expression von Genen liegen stochastische Prozesse zu Grunde, die zu Fluktuationen in der Menge von Proteinen eines jeden Gens führen. Zu starke Fluktuationen in Proteinmengen können für Organismen schädlich sein, da die meisten zellulären Prozesse auf der präzisen Wechselwirkung von Proteinen beruhen.  Diese Dissertationsschrift



befasst sich mit dem Einfluss von post-transkriptionellen Regulationsmechanismen auf die stochastischen Prozesse der Genexpression. Mittels bioinformatischer Datenanalyse, mathematischer Modellierung und gezielten Einzelzellexperimenten wird mit Fokus auf die in Mehrzellern weitverbreiteten microRNAs erforscht unter welchen Voraussetzungen Organismen post-transkriptionelle Regulation zu Verringerung von Fluktuationen benutzen können.  Die zentrale Erkenntnis der vorliegenden Arbeit ist, dass microRNAs für die meisten Gene Fluktuationen verringern können und auch zu diesem Zweck genutzt werden.