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1. |
Record Nr. |
UNINA9910791221003321 |
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Autore |
Mosher Clayton James |
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Titolo |
The mismeasure of crime [[electronic resource] /] / Clayton J. Mosher, Terance D. Miethe, Timothy C. Hart |
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Pubbl/distr/stampa |
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Los Angeles, Calif. ; ; London, : SAGE, 2011 |
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ISBN |
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1-4833-4949-7 |
1-4522-3916-9 |
1-4522-2394-7 |
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Edizione |
[2nd ed.] |
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Descrizione fisica |
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1 online resource (xii, 265 p.) : ill |
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Altri autori (Persone) |
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MietheTerance D |
HartTimothy C |
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Disciplina |
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Soggetti |
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Criminal statistics |
Criminal statistics - United States |
Victims of crimes surveys |
Victims of crimes surveys - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction: The pervasiveness (and limitations) of measurement -- The history of measuring crime -- Official crime data -- Self-report studies -- Victimization surveys -- Crime patterns, evaluating crime policies, and criminological theories. |
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Sommario/riassunto |
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'The Mismeasure of Crime' addresses the measurement of crime both historically and cross-nationally. It examines the strengths and weaknesses of each data source, the fundamental issues surrounding their accuracy, and the applications of these data in theoretical and policy research. |
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2. |
Record Nr. |
UNINA9910791951903321 |
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Autore |
Brauner David <1968-> |
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Titolo |
Philip Roth / / David Brauner |
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Pubbl/distr/stampa |
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Manchester, UK : , : Manchester University Press, , 2013 |
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©2007 |
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ISBN |
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0-7190-7425-8 |
1-78170-093-1 |
1-84779-164-6 |
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Descrizione fisica |
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1 online resource (x, 243 pages) : digital file(s) |
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Collana |
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Contemporary American and Canadian Writers |
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Disciplina |
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Soggetti |
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American fiction - 20th century - History and criticism |
Literature |
Literature: History & Criticism |
LITERARY CRITICISM / Jewish |
Literature: history & criticism |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; Series editors' foreword; Acknowledgements; 1 Introduction; 2 The trials of Nathan Zuckerman, or Jewry as jury: judging Jews in Zuckerman Bound; 3 The 'credible incredible and the incredible credible': generic experimentation in My Life as a Man, The Counterlife, The Facts, Deception and Operation Shylock; 4 Old men behaving badly: morality, mortality and masculinity in Sabbath's Theater; 5 History and the anti-pastoral: Utopian dreams and rituals of purification in the 'American Trilogy' |
6 Fantasies of flight and flights of fancy: rewriting history and retreating from trauma in The Plot Against AmericaAfterword; Works cited; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; Y; Z |
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Sommario/riassunto |
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This is a groundbreaking study of the most important contemporary American novelist, Philip Roth. Reading the author alongside a number of his contemporaries, and focusing particularly on his later fiction, this book offers a highly accessible, informative and persuasive view of |
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Roth as an intellectually adventurous and stylistically brilliant writer who constantly reinvents himself in surprising ways. At the heart of this book are a number of detailed and nuanced readings of Roth's works both in terms of their relationships with each other and with fiction by Nathaniel Hawthorne, Thomas Pynch |
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3. |
Record Nr. |
UNINA9910227346103321 |
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Autore |
Emanuela Corsini |
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Titolo |
Biomarkers in Drug Hypersensitivity |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (104 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions. Drug-induced hypersensitivity reactions involve complex mechanisms that include, among others, the metabolic activation and haptenization of drug metabolites. Hence, factors that influence the pharmacokinetics of drug and metabolites may contribute to the development of some drug-induced hypersensitivity reactions. This implies that processes such as ADME (absorption, distribution, metabolism and excretion) that are typically involved in type A adverse drug reactions, may have a role in hypersensitivity reactions too. In addition to metabolic activation, several signal transduction pathways |
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participate and modulate the development and the clinical presentation of drug hypersensitivity. The diverse mechanisms underlying such drug-hypersensitivity reactions lead to four major groups of reactions according to the Gell and Coombs classification: immediate, cytotoxic, immune complex and delayed. The enormous complexity of drug-hypersensitivity reactions is a consequence of the variety of mechanisms involved, which may be related, among others, to drug metabolism, generation of antigenic signals, stimulation and maturation of dendritic cells, presentation of haptens and mechanisms of cytotoxicity. In addition, a plethora of possible clinical presentations exists, including urticaria, angioedema, anaphylaxis, cytopenias, nephritis, serum sickness, vasculitis, contact dermatitis, drug rash, eosinophilia and systemic symptoms, Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalized exanthematous pustulosis. The rapid progress in the field in recent years indicates that the combination of several disciplines is essential to understand the mechanisms involved in this particular, and not completely understood, type of adverse drug reactions. The objective of this Research Topic is to present insights obtained from both basic and clinical scientists, which may include studies related to the identification, validation, refinement and clinical implementation of biomarkers for drug-induced hypersensitivity. The Topic aims to include recent findings related, but not limited to, potential phenomic, genomic, proteomic, metabolomic and signal transduction biomarkers. These biomarkers could eventually be used in clinical practice and/or these might contribute, as a proof of concept, to our understanding of the complex events leading to drug hypersensitivity reactions. In addition the Topic will cover recent developments and methodological advances in the diagnosis, prevention and therapeutic management of drug-induced hypersensitivity. |
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