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Record Nr. |
UNINA9910583324403321 |
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Titolo |
Approaches to the purifacation, analysis and characterization of antibody-based therapeutics / / edited by Allan Matte [and seven others] |
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Pubbl/distr/stampa |
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Amsterdam, Netherlands : , : Elsevier Limited, , [2020] |
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©2020 |
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ISBN |
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Descrizione fisica |
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1 online resource (224 pages) |
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Disciplina |
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Soggetti |
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Antibody-drug conjugates |
Immunoglobulins |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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1. Overview of therapeutic antibodies; 2. Platform purification approaches; 3. Strategies in the context of mAb downstream process development; 4. Process-scale purification of antibody therapeutics; 5. Process analytics for mAb purification and process development; 6. Automation approaches for small-scale mAb purification and assay development; 7. Glycan characterization of therapeutics mAbs; 8. Characterization of therapeutic antibodies using mass spectrometry; 9. Antibody binding studies using surface plasmon resonance and bio-layer interferometry methods; 10. Higher-order structure characterization methods; 11. Conformational and colloidal stability analysis of mAbs; 12. Future trends and opportunities. |
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Sommario/riassunto |
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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. |
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2. |
Record Nr. |
UNINA9910791783903321 |
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Autore |
Grose Christian R. |
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Titolo |
Congress in black and white : race and representation in Washington and at home / / Christian R. Grose [[electronic resource]] |
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Pubbl/distr/stampa |
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Cambridge : , : Cambridge University Press, , 2011 |
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ISBN |
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1-107-22080-7 |
1-139-01247-9 |
1-283-01599-4 |
9786613015990 |
1-139-01168-5 |
1-139-01194-4 |
1-139-01115-4 |
1-139-01088-3 |
0-511-97682-8 |
1-139-01141-3 |
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Descrizione fisica |
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1 online resource (xiv, 242 pages) : digital, PDF file(s) |
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Disciplina |
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Soggetti |
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African American legislators |
Gerrymandering - United States |
African Americans - Government policy |
Civil rights - Government policy - United States |
Representative government and representation - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Title from publisher's bibliographic system (viewed on 05 Oct 2015). |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Machine generated contents note: 1. African-American legislators, African-American districts, or democrats?; 2. A unified theory of African-American representation in Congress; 3. The "hollow hope" of civil rights change in the US House; 4. Location, location, location: delivering constituency service to African-Americans; 5. Constituency service in the district: connecting black legislators, black staff, and black voters; 6. Bringing home the bacon: delivering federal "pork" to |
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African-Americans; 7. The future of racial redistricting: black decisive districts. |
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Sommario/riassunto |
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The symbolic importance of Barack Obama's election is without question. But beyond symbolism, does the election of African-American politicians matter? Grose argues that it does and presents a unified theory of representation. Electing African-American legislators yields more federal dollars and congressional attention directed toward African-American voters. However, race and affirmative action gerrymandering have no impact on public policy passed in Congress. Grose is the first to examine a natural experiment and exceptional moment in history in which black legislators - especially in the U.S. South - represented districts with a majority of white constituents. This is the first systematic examination of the effect of a legislator's race above and beyond the effect of constituency racial characteristics. Grose offers policy prescriptions, including the suggestion that voting rights advocates, the courts, and redistricters draw 'black decisive districts', electorally competitive districts that are likely to elect African Americans. |
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