Natural products from actinomycetes : diversity, ecology and drug discovery / / Ravishankar V. Rai and Jamuna A. Bai, editors

• Record Nr.: UNINA9910743342903321
• Pubbl/distr/stampa: Singapore : , : Springer, , [2022]; ©2022
• ISBN: 981-16-6131-6; 981-16-6132-4
• Descrizione fisica: 1 online resource (512 pages)
• Disciplina: 589.23
• Soggetti: Microbiological chemistry; Natural products - Analysis
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di contenuto: Intro -- Preface -- Contents -- Editors and Contributors -- About the Editors -- Contributors -- 1: Actinobacteria from Marine Environments: A Unique Source of Natural Products -- 1.1 Introduction -- 1.2 Marine Actinobacteria: Where Can We Find Them? -- 1.2.1 Sediments and Seawater -- 1.2.2 Marine Fauna -- 1.2.2.1 Corals -- 1.2.2.2 Sponges -- 1.2.2.3 Tunicates, Mollusks, Marine Fishes, and Other Organisms -- 1.2.3 Marine Flora: Macroalgae, Seagrass, and Mangrove -- 1.3 Bioactive Metabolites Produced by Marine Actinobacteria -- 1.3.1 Pharmaceuticals -- 1.3.2 Other Bioactive Compounds -- 1.4 From the Field to the Laboratory: Best Approaches to Isolate Marine Actinobacteria -- 1.5 New Tools for Bioprospecting Actinobacteria -- 1.6 Conclusions and Future Perspectives -- References -- 2: Exploration of Insects and Mollusks for New Secondary Metabolites from Actinobacteria -- 2.1 Introduction -- 2.2 Secondary Metabolites from Actinobacteria -- 2.3 Insect-Microbe Interactions -- 2.4 Actinobacteria Isolated from Ants -- 2.5 Actinobacteria Isolated from Termites -- 2.6 Actinobacteria Isolated from Bees -- 2.7 Actinobacteria Isolated from Wasps -- 2.8 Actinobacteria Isolated from Beetles -- 2.9 Actinobacteria Isolated from Bugs -- 2.10 Mollusca-Microbe Interactions -- 2.11 Actinobacteria Isolated from Nudibranch -- 2.12 Actinobacteria Isolated from Snails -- 2.13 Actinobacteria Isolated from ; Clams -- 2.14 Conclusion and Future Perspectives -- References -- 3: Polar Actinobacteria: A Source of Biosynthetic Diversity -- 3.1 Introduction -- 3.1.1 Actinobacteria from the Poles -- 3.1.2 Compounds Isolated from Polar Actinobacteria -- 3.2 Diversity of Biosynthetic Gene Clusters in Polar Actinobacteria -- 3.2.1 PCR-Based Approach -- 3.2.2 Genomic and Metagenomic Approaches -- 3.3 Conclusions and Future Perspectives -- References.; 4: Actinobacteria from Arid Environments and Their Biotechnological Applications -- 4.1 Introduction -- 4.1.1 Desert Environment -- 4.1.2 Actinobacteria from Desert -- 4.2 Isolation Strategies for Desert Actinobacteria -- 4.2.1 Pre-treatment of Environmental Samples -- 4.2.2 Selective Media and Antibiotics -- 4.2.3 Growth Conditions of Desert Actinobacteria -- 4.2.4 Selection of Actinobacterial Colonies -- 4.3 Biotechnological Applications -- 4.3.1 Environmental and Industrial Applications -- 4.3.2 Agricultural Applications -- 4.3.3 Health Science Applications -- 4.4 Conclusion and Future Perspectives -- References -- 5: Endophytic Actinobacteria in Biosynthesis of Bioactive Metabolites and Their Application in Improving Crop Yield and Sustai... -- 5.1 Introduction -- 5.2 Endophytic Microbes -- 5.3 Endophytic Actinobacteria for Sustainable Agriculture Improvement -- 5.4 Biological Control -- 5.5 Abiotic Stress: Reduction, Alleviation and Control -- 5.6 Plant Growth Promotion -- 5.6.1 Siderophore Production -- 5.6.2 Nitrogen Fixation -- 5.6.2.1 Interaction with Rhizobium -- 5.6.3 Phosphate Solubilization -- 5.6.4 ACC Deaminase Activation -- 5.6.5 Phytohormone Production -- 5.7 Crop Yields -- 5.8 Conclusion and Future Perspectives -- References -- 6: An Overview on Natural Product from Endophytic Actinomycetes -- 6.1 Introduction -- 6.2 Endophytic Actinomycetes -- 6.3 Endophytic Actinomycetes from Various Sources -- 6.4 Marine Endophytic Actinomycetes -- 6.5 Biomedical Applications of Marine Endophytic Actinomycetes -- 6.6 Industrially Important Actinomycetes and Their Application -- 6.7 Secondary Metabolites of Endophytic Actinomycetes -- 6.8 Conclusion and Future Prospectives -- References -- 7: Regulation of Secondary Metabolites Through Signaling Molecules in Streptomyces -- 7.1 Introduction.; 7.2 Structural Diversity of the Streptomyces Signaling Molecules -- 7.3 The Signaling Molecule-Dependent Regulatory Pathway for Secondary Metabolite Production -- 7.4 The Receptors of Regulatory Signaling Molecules -- 7.5 The Pseudo-receptor Proteins: Their Function and Interactive Ligands -- 7.6 Signaling Molecules/Antibiotics Act as Intra-/Interspecies Signals -- 7.7 The Streptomyces Antibiotic Regulatory Proteins (SARP): One of the Main Targets of Signaling Molecule/Receptor System -- 7.8 Natural Product Discovery Through Manipulation of Regulatory System -- 7.9 Conclusion and Future Perspective -- References -- 8: New Strategies to Activate Secondary Metabolism in Streptomyces -- 8.1 Streptomycetes Are Complex Mycelial Sporulating Bacteria and the Main Source of Bioactive Compounds -- 8.1.1 Streptomyces Development -- 8.1.2 Streptomyces Differentiation and Industrial Fermentations -- 8.1.3 Novel Drug Discovery Approaches -- 8.1.4 Screening for New Bioactive Compounds from Natural Microorganisms -- 8.2 New Strategies for High-Throughput Screening from Natural Microorganisms -- 8.2.1 New Strategies for Actinomycete Strain Isolation -- 8.2.1.1 Exploring New Niches -- 8.2.1.2 Symbiotic Relationships -- 8.2.1.3 Non-culturable Microorganisms -- 8.2.2 Old and New Strategies to Activate and Explore Secondary Metabolism in Actinomycetes -- 8.2.2.1 Selective Methods to Improve the Production of Known Compound -- 8.2.2.1.1 Engineering Precursor Biosynthesis and Specific Regulators -- 8.2.2.1.2 ; Heterologous Expression, Omics-Guided Secondary Metabolite Synthesis -- 8.2.2.1.3 Combinatorial Biosynthesis -- 8.2.2.2 Unselective Methods -- 8.2.2.2.1 Modifying the Culture Medium -- 8.2.2.2.2 Inducing Stress -- 8.2.2.2.3 Random Mutagenesis -- 8.2.2.2.4 Ribosomal Engineering -- 8.2.2.2.5 Genome Mining -- 8.2.2.2.6 Co-cultures and Elicitors.; 8.2.2.2.7 Strategies to Modulate Secondary Metabolism Based on Macroscopic Morphology (Pellet and Clump Formation) -- 8.2.2.2.8 Strategies to Modulate Secondary Metabolism Based on Mycelium Differentiation and Programmed Cell Death -- 8.2.2.2.9 Strategies to Modulate Secondary Metabolism Based on the Use of Non-pathogenic Targets to Test the Biological Activi... -- 8.3 Conclusions -- References -- 9: Novel Agroactive Secondary Metabolites from Actinomycetes in the Past Two Decades with Focus on Screening Strategies and Di... -- 9.1 Introduction -- 9.2 Exploring Actinomycetes Producing Agroactive Secondary Metabolites from New Habitats -- 9.2.1 Actinomycetes from Marine Environment -- 9.2.2 Actinomycetes from Extreme Terrestrial Environment -- 9.2.3 Terrestrial Plant- or Animal-Associated Actinomycetes -- 9.3 Phylogenetic Analysis of the Agroactive Secondary Metabolites-Producing Actinomycetes Strains -- 9.4 New Techniques for Accelerating the Process of Discovery of Novel Agroactive Secondary Metabolites -- 9.4.1 Chemical Screening -- 9.4.2 Gene Screening -- 9.4.3 Genome Mining -- 9.5 Traditional Methods for Discovering New Agroactive Secondary Metabolites from Actinomycetes -- 9.5.1 Mutagenesis -- 9.5.2 Bioconversion -- 9.6 The Designed Biosynthesis of New Agroactive Secondary Metabolites in Post-omics Era -- 9.6.1 Gene Replacement -- 9.6.2 Gene Overexpression -- 9.6.3 Gene Deletion or Disruption -- 9.6.4 Expression of Introduced Heterogeneous Genes -- 9.7 Novel Agroactive Secondary Metabolites from Actinomycetes in the Past Two Decades -- 9.7.1 Novel Insecticidal and Acaricidal Metabolites -- 9.7.2 Novel Antifungal or Bactericidal Metabolites -- 9.7.3 Novel Herbicidal, Phytotoxic, or Plant Growth Regulating Metabolites -- 9.7.4 Novel Nematicidal Metabolites -- 9.7.5 Novel Antiphytoviral Metabolites.; 9.8 The Development of Agrochemicals with Leads from Actinomycete and Their Application in Crop Protection -- 9.9 Conclusion -- References -- 10: Quorum Sensing and Quorum Quenching Metabolites in Actinomycetes -- 10.1 Introduction -- 10.2 QS Signals in Actinomycetes -- 10.3 QS in Streptomyces Species -- 10.3.1 Streptomyces griseus -- 10.3.2 Streptomyces virginiae -- 10.3.3 Streptomyces coelicolor -- 10.3.4 Streptomyces avermitilis -- 10.3.5 Streptomyces rochei -- 10.3.6 Streptomyces natalensis -- 10.3.7 Streptomyces globisporus -- 10.3.8 Streptomyces albidoflavus -- 10.3.9 Streptomyces lavendulae -- 10.3.10 Streptomyces filipinensis -- 10.3.11 Streptomyces chattanoogensis -- 10.3.12 Streptomyces tsukubaensis -- 10.3.13 Antibiotics as Signaling Molecules -- 10.4 QS in Non-Streptomyces Species -- 10.5 Detection of QS Signals and Receptors in Actinomycetes -- 10.6 Interspecies Signaling in Actinomycetes -- 10.7 QS-Regulated Phenotypes in Actinomycetes -- 10.8 Quorum Sensing Inhibition in Actinomycetes -- 10.8.1 Quorum Quenching Enzymes in Actinomycetes -- 10.8.1.1 Quorum Quenching Enzymes in Streptomyces sp. -- 10.8.1.2 Quorum Quenching Enzymes in Rhodococcus sp. -- 10.8.1.3 Quorum Quenching Enzymes in Nocardioides sp. -- 10.8.2 Quorum Sensing Inhibitory Compounds in Actinomycetes -- 10.8.2.1 Anti-virulence Compounds Against Oral Pathogens -- 10.8.2.2 QS and Biofilm Inhibitory Compounds Against Vibrio sp. -- 10.8.2.3 Anti-infective Compounds Against ESKAPE Pathogens -- 10.8.2.4 Quorum Sensing Inhibitory Compounds Against ; Other Bacterial Pathogens -- 10.8.2.5 Quorum Sensing Inhibitory Compounds Against Plant Pathogens -- 10.8.2.6 Quorum Sensing Inhibitory Compounds Against Fungal Pathogens -- 10.9 Conclusion and Future Prospectives -- References -- 11: Metabolic Engineering of Actinomycetes for Natural Product Discovery -- 11.1 Overview.; 11.2 Identification and Capture of Biosynthetic Gene Clusters (BGCs).

The phonetics of fingerspelling [[electronic resource] /] / Sherman Wilcox

• Record Nr.: UNINA9910789874203321
• Autore: Wilcox Sherman
• Pubbl/distr/stampa: Amsterdam ; ; Philadelphia, : J. Benjamins Pub. Co., 1992
• ISBN: 1-283-42440-1; 9786613424402; 90-272-7719-2
• Descrizione fisica: 1 online resource (114 pages)
• Collana: Studies in speech pathology and clinical linguistics, , 0927-1813 ; ; v. 4
• Disciplina: 419
• Soggetti: Finger spelling; Grammar, Comparative and general - Phonetics
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: THE PHONETICS OF FINGERSPELLING; Editorial page; Title page; Copyright page; Table of contents; Chapter 1. A Linguistic Approach to Fingerspelling; The Structure of Signed Languages; Signs as Unsegmentable Wholes; Signs as Simultaneously Segmentahle; Signs as Sequentially Segmentahle; Fingerspelling; Lexical Borrowing; Research on Fingerspelling; Fingerspelling as a Research Tool; Models of Fingerspelling; The Production and Perception of Fingerspelling; Learning to Fingerspell; Fingerspelling Fluency; Coarticulation in Fingerspelling; Kinematics, Dynamics, and Articulatory Movements; Organization of the Studies Learning to Fingerspell; The Phonetics of Fingerspelling; Chapter 2. Learning to Fingerspell; Adult Acquisition of Fingerspelling; Method; Subjects; Materials; Procedures; Results; Discussion; Chapter 3. The Measurement of Fingerspelling Movement; Background; Hardware; Software; Sample Data Analysis; Methods and ; Procedures for Motion Analysis Studies; Subjects; Stimulus Materials; Marker Placement and Attachment; Sampling Times and Rates; Room and Camera Arrangement; Calibratio; Chapter 4. Targets and Transitions; Models Revisited; The Salience of Targets and Transitions Dynamic Modeling of Phonetic Structure; Chapter 5. Towards a Dynamics of Fingerspelling; From Kinematics to Dynamics; Fingerspelling Speed; Cooperativity in Fingerspelling Production; Discussion; Chapter 6. Future Directions in Signed Language Research; The Linguistic Study of Fingerspelling; Limitations and Suggestions for Further Study; Motion Analysis of Signed Language; Learning to Fingerspell; Models of Fingerspelling; Sign Science and Speech Science: The Search for Unity; Speech as Gestures; Signing as Gestures; Is Speech Special?; NOTES; Notes to Chapter One Notes to Chapter Two; Notes to Chapter Four; Notes to Chapter Five; Notes to Chapter Six; References; Index
• Sommario/riassunto: We now know that natural signed languages such as American Sign Language, French Sign Language, British Sign Language and others are fully independent languages. But natural signed languages are only one way of conveying language in the visual/gestural modality. Signed languages also have mechanisms for representing the material of oral languages. Fingerspelling is one example of such a representational system. This book examines fingerspelling from a phonetic perspective. Several studies of the kinematics of fingerspelling articulators are reported. From these detailed analyses of articulator