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1. |
Record Nr. |
UNINA9910459888903321 |
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Autore |
Kettley Nigel C |
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Titolo |
Theory building in educational research [[electronic resource] /] / Nigel Kettley |
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Pubbl/distr/stampa |
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New York, : Continuum International Pub. Group, c2010 |
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ISBN |
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1-282-76570-1 |
9786612765704 |
1-4411-1008-9 |
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Descrizione fisica |
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1 online resource (225 p.) |
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Disciplina |
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Soggetti |
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Education - Research - Methodology |
Education - Research - Great Britain |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Contents; List of tables and figures; Glossary; Preface; Part I: Introduction: Crisis and Corrections; 1 The crisis of theory building and theory in educational research; 2 Toward productive and powerful theory building and theory; Part II: The Interface of Theory and Method; 3 Paradigm wars: Philosophies, methodologies and theory building; 4 Making sense together? An alternative model of theory building; Part III: Educational Theory Building in Practice; 5 The practical foundations of theory building; 6 Interpretation and imagination: Developing theoretical frameworks |
Part IV: Conclusion: Prospects and Promises7 Theory building, social explanation and education policy; 8 Promoting change: The promise and pitfalls of theory building; References; Index; A; B; C; D; E; F; G; H; I; K; L; M; N; O; P; Q; R; S; T; U; V; W |
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Sommario/riassunto |
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This volume provides comprehensive guidance on the subjects of concept generation and theory building in educational research. By deploying the conceptual, methodological and theoretical principles of the Cambridge School of Sociology, that underpin a range of contemporary empirical research, the author shows how theory building, and theory, in contemporary educational research is in a state |
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of crisis. In his compelling analysis, Nigel Kettley develops an alternative approach to theory building in educational research, and explores a radical new system for facilitating the growth of knowledge |
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2. |
Record Nr. |
UNINA9910787805003321 |
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Titolo |
Cardiovascular genetics and genomics in clinical practice / / editors, Sanjiv J. Shah, Donna K. Arnett |
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Pubbl/distr/stampa |
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New York : , : demosMEDICAL, , 2015 |
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©2015 |
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ISBN |
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Descrizione fisica |
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1 online resource (326 p.) |
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Disciplina |
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Soggetti |
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Heart - Diseases - Genetic aspects |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters and index. |
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Nota di contenuto |
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Cover; Title; Copyright; Contents; Contributors; Preface; References; Video Captions; Share Cardiovascular Genetics and Genomics in Clinical Practice; Part I: Genetics and Genomics: The Basics; Chapter 1: Mendelian Genetics; Take Home Points; Mendel's Laws; Modes of Inheritance; Methods Used to Determine Modes of Inheritance; Clinical Utility of Genetic Information; Glossary; References; Chapter 2: Genetics of Complex Traits; Take Home Points; Quantitative Traits; Familial Aggregation; Measuring Familial Aggregation; Concordance Versus Discordance; Allele Sharing; Twin Studies |
Concordance of MZ Versus DZ TwinsTwins Reared Apart; Limitations of Twin Studies; Heritability; Conclusions; References; Chapter 3: Genome-Wide Association Studies; Take Home Points; Why do we Need GWAS?; Genetic Basis of GWAS; Simple GWAS; Beyond GWAS Basics: Challenges and Limitations; Limitations of GWAS; Using GWAS Results; GWAS Success in Cardiovascular Disease; Summary; Glossary; References; Chapter 4: Bioinformatics; Take Home Points; Following Up on Linkage Analyses; Following Up on Genome-Wide Association |
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Studies; Obtaining Information on Candidate Genes |
Characterizing DNA Variants Found within GenesReferences; Chapter 5: Epigenetics; Take Home Points; DNA Methylation; Histone Modifications; Challenges and Opportunities for Human CVD Epigenetic Studies; References; Chapter 6: MicroRNAs; Take Home Points; MicroRNA Structure and Function; MicroRNA and Cardiac Function; MicroRNA as Biomarkers; MicroRNA Therapeutics; Conclusions; References; Chapter 7: Gene Expression; Take Home Points; Microarray Technology; Quality Control; Data Normalization; Data Analysis; Ontology and Pathway Analysis; Validation and Meta-Analysis; Conclusions; References |
Chapter 8: Whole-Exome and Whole-Genome SequencingTake Home Points; Overview of Exome Chip, WES, and WGS Technologies; Available Strategies for the Conduct of WES Studies; Application of WES to Cardiovascular Disease; Next-Generation Sequencing Technologies for Clinical Diagnostics; Future Directions; Conclusions; References; Chapter 9: Gene-Environment Interactions; Take Home Points; Defining Interactions; Investigating Interactions: Study Design; Investigating Interactions: Statistical Power; Gene-Environment Interactions in Cardiovascular Disease |
The Promise and Challenges of Gene-Environment Interaction ResearchSummary; References; Chapter 10: Genetic Counseling; Take Home Points; Definition of Genetic Counseling; The Power of the Pedigree and Family Health History; Risk Assessment Beyond Basic Mendelian Principle; Psychosocial Counseling; Genetic Counselors in Cardiovascular Practice; Cardiovascular Genetic Testing; Partners in Practice; Conclusions; References; Part II: Genetics of Cardiovascular Disorders/Traits; Chapter 11: Blood Pressure Genomics; Take Home Points |
Case Study: Severe Monogenic Hypertension-An Application of Whole-Exome Sequencing |
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Sommario/riassunto |
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Cardiovascular Genetics and Genomics in Clinical Practice presents clinical cases to illuminate basic concepts of cardiovascular genetics and genomics as practitioners encounter them in day-to-day practice. The unique use of real-world case discussions facilitates the memorization and understanding of basic principles, which can be more readily applied to actual cases. Cardiovascular Genetics and Genomics in Clinical Practice features a step-by-step learning process that begins with an easy-to-understand ""primer"" of basic scientific concepts regarding cardiovascular genetics and genomics fol |
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