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Record Nr. |
UNINA9910780425603321 |
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Autore |
Volpe Richard |
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Titolo |
A compendium of effective, evidence-based best practices in prevention of neurotrauma / / Richard Volpe, John Lewko, and Angela Batra |
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Pubbl/distr/stampa |
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Toronto, [Canada] ; ; Buffalo, [New York] ; ; London, [England] : , : University of Toronto Press, , 2002 |
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©2002 |
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ISBN |
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1-282-02258-X |
9786612022586 |
1-4426-7028-2 |
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Descrizione fisica |
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1 online resource (386 p.) |
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Disciplina |
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Soggetti |
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Nervous system - Wounds and injuries - Prevention |
Accidents - Prevention |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Introduction. Aims of project ; Facets of unintentional injury prevention ; Unintentional head and spinal cord injuries across the lifespan ; Evaluation framework and the BRIO case study model ; Methodology ; Implementation of best practices survey ; Summary of criteria ; Prologue to the case studies. Case studies. Prevention of asphyxiation-related injuries : Best practices: Pool fencing: effectiveness of legislation and education -- Prevention of motor and other road vehicle-related injuries : Best practices: Red light camera enforcement ; Roundabouts ; Rumblestrips ; Child Pedestrian Injury Prevention Project (CPIPP) ; RoadWise: a Manitoba Public Insurance safety campaign ; SafetyBeltSafe U.S.A : Promising practices: Retro-reflective clothing ; Intelligent traffic signals for pedestrian detection ; SAFE KIDS Buckle Up: a National SAFE KIDS Campaign project ; The PARTY program ; HEROES -- Prevention of sports, playground, and recreation-related injuries : Best practices: Bicycle helmets: educational and legislative intervention to increase use in Victoria, Australia ; Snowmobile Trail Officer Patrol |
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Program (STOP) : Promising practices: The varsity athlete concussion research project ; Fair-play rules in youth ice hockey ; The National Action Plan for the Prevention of Playground Injuries -- Prevention of farm-related and occupational injuries : Best practices: Tractor Rollover Protective Structure (ROPS) rebate scheme. |
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Sommario/riassunto |
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Every year, thousands of people suffer unintentional neurotrauma injuries due to motor vehicle accidents, sports and playground injuries, and farm and occupational injuries. Although injury reduction targets have been established and indicators have been developed to measure progress in prevention, no method of evaluating and accessing effective injury prevention practices is currently available. This compendium aims to fill this gap by portraying exemplars that have the potential to reduce the incidence of these injuries, and by providing a detailed methodology that is effective in identifying innovative best practices. The intention of this work is not to be encyclopaedic; rather, the authors have reviewed the twenty-eight best and promising practices, taking into consideration the complexity of injury dynamics, and analysed what constitutes a best practice as the shift is made from individual clinical practice to the collective practice associated with policy implementation at the community level. The first worldwide assessment of best practices, this work is expected to be an important contribution to the emerging field of unintentional-injury prevention with its unique coverage of the life span, up-to-date bibliography, and directory of the major programs and professionals. |
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2. |
Record Nr. |
UNINA9910787665603321 |
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Titolo |
Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft |
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Pubbl/distr/stampa |
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Norfolk, England : , : Caister Academic Press, , [2013] |
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©2013 |
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ISBN |
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Descrizione fisica |
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1 online resource (249 p.) |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Table of Contents; Chapter 1. Receptor-related Risk Factors for Verotoxin Pathogenesis; Verotoxins and their receptors; Receptor glycolipid; B subunit receptor-binding sites; VT signalling and internalization; Cholesterol masking of VT receptors; New model for VTB subunit pentamer binding plasma membrane Gb3; Cholesterol is key for VT-Gb3 retrograde transport; Regulation of Gb3 biosynthesis; Soluble GSL mimics; Conclusions; References; Chapter 2. The Helicobacter pylori CagA Protein: A Multifunctional BacterialToxin Delivered by Type IV Secretion; Introduction |
The cag pathogenicity island and its effector protein CagAThe Cag type IV secretion system as a toxin delivery system; CagA interaction partners and associated effects in host cells; Conclusions; Chapter 3. Pore-forming Toxins; Introduction; Introduction to Staphylococcus aureus α-haemolysin; Nomenclature and early observations; Primary structure and regulation of toxin production; Three-dimensional structure and function; Role in disease pathogenesis; Summary and future perspectives - α-toxin |
Introduction to the cholesterol-dependent cytolysins and membrane attack complex/perforin (MACPF) family proteinsGeneral features of the CDC primary structure; The CDC monomer crystal structure; Secretion of the CDCs; Cellular recognition; The CDC membrane anchoring system; The CDC allosteric pathway; Formation of the prepore oligomer; Formation of the pore complex; Ring versus arc oligomers; |
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The CDCs and bacterial pathogenesis; The membrane attack complex/perforin (MACPF) proteins; Summary and futureperspectives - CDCs andMACPF proteins; References |
Chapter 4. Bacterial Enterotoxins as Immunomodulators and Vaccine AdjuvantsIntroduction; Cholera toxin: the prototype for ADP-ribosylating holotoxin adjuvants; LT: a more complex family of holotoxin adjuvants; Are ADP-ribosylating toxins in general good adjuvants?; Taking toxin adjuvant immunomodulation one step further; Concluding remarks; References; Chapter 5. Mobile Genetic Elements as Carriers for Bacterial Virulence Genes; Core and adaptive genome; The mobile bacterial genome; Mobile genetic elements and their role in virulence; Why MGEs encode exotoxins and other virulence factors? |
Role of SOS inductionBacteriophage-encoding toxins and other virulence factors; Plasmids encoding toxins; Pathogenicity islands encoding toxins; Open questions; Web resources; References; Chapter 6. The Staphylococcal Superantigen-like Toxins; Introduction; The SSLs - an introduction; Genetics of the ssls; Molecular biology of the SSLs; SSL-related S. aureus immune evasion molecules; Mechanisms of immune evasion mediated by SSLs; Novel SSL-associated applications; Concluding remarks; References; Chapter 7. Botulinum Neurotoxins as Therapeutics; Introduction |
Mechanistic basis of BoNTs as therapeutics |
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Sommario/riassunto |
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Toxins are virulence determinants that play an important role in microbial pathogenicity and/or evasion of the host immune response. This makes them ideal targets for the development of novel antimicrobial strategies. The potential applications of toxin research extend beyond simply combating microbial pathogens, and include use as novel anti-cancer drugs and other front-line medicines and as tools in neurobiology. In the field of cellular biology, toxins have become invaluable as tools for the manipulation and investigation of fundamental cellular and physiological processes. Research in this |
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