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1. |
Record Nr. |
UNINA9910452690803321 |
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Autore |
Endres Robert G |
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Titolo |
Physical principles in sensing and signaling [[electronic resource] ] : with an introduction to modeling in biology / / Robert G. Endres |
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Pubbl/distr/stampa |
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Oxford, : Oxford University Press, 2013 |
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ISBN |
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1-283-85621-2 |
0-19-165428-0 |
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Descrizione fisica |
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1 online resource (158 p.) |
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Disciplina |
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Soggetti |
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Biology - Simulation methods |
Biology - Mathematical models |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Cover; Contents; 1 Introduction; Chapter summary; Further reading; 2 Chemotaxis in bacterium Escherichia coli; 2.1 Chemical gradient sensing; 2.2 "Nose and brain": the receptor cluster; 2.3 E. coli chemotaxis pathway; 2.4 Experimental approaches; 2.5 Time-course data and dose-response curves; Chapter summary; Further reading; 3 Physical concepts; 3.1 Diffusion; 3.2 Boltzmann distribution; 3.3 Ligand-receptor binding; 3.4 Fluctuation-dissipation theorem; Chapter summary; Further reading; 4 Mathematical tools; 4.1 Ordinary differential equations; 4.2 Kinetic laws; 4.3 Master equation |
4.4 Poisson distribution4.5 Waiting-time distribution; 4.6 Langevin small-noise approximation; 4.7 Information theory; Chapter summary; Further reading; 5 Signal amplification and integration; 5.1 Cooperativity by allostery; 5.2 Emergence of allostery from microscopic details; 5.3 Two-state equilibrium receptor model; 5.4 Monod-Wyman-Changeux model for receptor signaling; 5.5 Alternative Ising model for receptor cluster; Chapter summary; Further reading; 6 Robust precise adaptation; 6.1 Energy-landscape picture of adaptation; 6.2 Dynamics of adaptation; 6.3 Chemotactic response function |
6.4 Integral-feedback control6.5 Assistance neighborhoods; Chapter |
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summary; Further reading; 7 Polar receptor localization and clustering; 7.1 Trimer of dimers; 7.2 Elastic cluster-membrane model; 7.3 Polar receptor clustering; Chapter summary; Further reading; 8 Accuracy of sensing; 8.1 Perfectly absorbing sphere; 8.2 Perfectly monitoring sphere; 8.3 Sensing with cell-surface receptors; Chapter summary; Further reading; 9 Motor impulse response; 9.1 Impulse response; 9.2 Time and frequency domains; 9.3 Minimal pathway model; 9.4 Linear response approximation; 9.5 Noise power spectra |
Chapter summaryFurther reading; 10 Optimization of pathway; 10.1 Optimal receptor-complex size; 10.2 Optimal adaptation dynamics; Chapter summary; Further reading; 11 "Seeing like a bacterium"; 11.1 Typical chemical gradients; 11.2 Weber's law; 11.3 Perception; 11.4 Fold-change detection; 11.5 Matching relations; 11.6 Predicting typical stimuli; Chapter summary; Further reading; 12 Beyond E. coli chemotaxis; Chapter summary; Further reading; Appendix More techniques; A.1 Derivation of the fluctuation-dissipation theorem; A.2 Variational principles and the Euler-Lagrange equation |
A.3 Gillespie simulationsA.4 Fokker-Planck approximation; A.5 Derivation of the Langevin noise; A.6 Time versus frequency domain; A.7 Model fitting to data; A.8 Principal component analysis; Chapter summary; Further reading; Index; A; B; C; D; E; F; G; H; I; L; M; N; O; P; Q; R; S; T; V; W |
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Sommario/riassunto |
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Although invisible to the bare eye, bacterial cells are large enough to make complex decisions. Cells are composed of thousands of different molecular species including DNA, proteins, and smaller molecules, allowing them to sense their environment, to process this information, and to respond accordingly. Such responses include expression of genes or the control of their movement. Despite these properties, a living cell exists in the physical world and follows its laws. Keeping thisin mind can help answer questions such as how cells work and why they implement solutions to problems the way they |
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2. |
Record Nr. |
UNINA9910784930503321 |
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Autore |
Healy Kieran Joseph <1973-> |
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Titolo |
Last best gifts [[electronic resource] ] : altruism and the market for human blood and organs / / Kieran Healy |
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Pubbl/distr/stampa |
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Chicago, : University of Chicago Press, 2006 |
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ISBN |
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1-282-73843-7 |
9786612738432 |
0-226-32238-6 |
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Descrizione fisica |
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1 online resource (208 p.) |
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Disciplina |
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Soggetti |
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Procurement of organs, tissues, etc |
Procurement of organs, tissues, etc - Economic aspects - United States |
Transplantation of organs, tissues, etc - Economic aspects - United States |
Tissue banks - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. 169-183) and index. |
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Nota di contenuto |
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Frontmatter -- Contents -- Illustrations -- Acknowledgments -- 1. Exchange in Human Goods -- 2. Making a Gift -- 3. The Logistics of Altruism -- 4. Collection Regimes and Donor Populations -- 5. Organizations and Obligations -- 6. Managing Gifts, Making Markets -- Appendix: Data Sources and Methods -- Notes -- Bibliography -- Index |
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Sommario/riassunto |
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More than any other altruistic gesture, blood and organ donation exemplifies the true spirit of self-sacrifice. Donors literally give of themselves for no reward so that the life of an individual-often anonymous-may be spared. But as the demand for blood and organs has grown, the value of a system that depends solely on gifts has been called into question, and the possibility has surfaced that donors might be supplemented or replaced by paid suppliers. Last Best Gifts offers a fresh perspective on this ethical dilemma by examining the social organization of blood and organ donation in Europe and the United States. Gifts of blood and organs are not given everywhere in the same way or to the same extent-contrasts that allow Kieran Healy to uncover |
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the pivotal role that institutions play in fashioning the contexts for donations. Procurement organizations, he shows, sustain altruism by providing opportunities to give and by producing public accounts of what giving means. In the end, Healy suggests, successful systems rest on the fairness of the exchange, rather than the purity of a donor's altruism or the size of a financial incentive. |
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