Advances in antiviral drug design . Volume 5 [[electronic resource] /] / editor, E. De Clercq

• Record Nr.: UNINA9910784598503321
• Pubbl/distr/stampa: Greenwich, CT ; ; London, England, : Jai Press, 2007
• ISBN: 1-281-11983-0; 9786611119836; 0-08-054824-5
• Descrizione fisica: 1 online resource (265 p.)
• Collana: Advances in antiviral drug design ; ; 5
• Altri autori (Persone): De ClercqErik
• Disciplina: 616.9; 616.9/25061/05; 616.91061
• Soggetti: Antiviral agents; Anti-infective agents
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: I. IntroductionII. Design; III. Synthesis; IV. Antiviral activity; Acknowledgements; References; Chapter 4. Synthesis and antiviral evaluation of broad spectrum, orally active analogs of cidofovir and other acyclic nucleoside phosphonates; I. Introduction; II. Synthesis of hexadecyloxypropyl and related esters of cidofovir; III. Antiviral evaluation and spectrum of activity; IV. Structure activity relationships; V. Cellular metabolism; VI. Oral pharmacokinetics and tissue distribution; VII. Antiviral activity in animal models of viral diseases; VIII. Alkoxyalkyl esters of (S)-HPMPA and other acyclic nucleoside phosphonatesIX. Conclusions; Acknowledgements; References; Chapter 5. CCR5 antagonistsCCR5 antagonists for the treatment ofHIV infection and AIDS; I. Introduction; II. Inhibition of HIV entry; III. CCR5 as a drug target; IV. The discovery of novel CCR5 antagonists; V. Molecular mechanisms; VI. Resistance to CCR5 antagonists in vitro and in the clinic; VII. Conclusions; References; Chapter 6. The medicinal chemistry of the DATADATA and DAPYDAPY series of HIV-1HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIsNNRTIs); AbstractI. Introduction; II. The diaryltriazine (DATA) series; III. The ; diarylpyrimidine (DAPY) series; IV. Conclusion; Acknowledgements; References; Index
• Sommario/riassunto: Regularly reviewing the ""state-of-the-art"" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.