The skin in systemic autoimmune diseases / / editors, Piercarlo Sarzi-Puttini [et al.]

• Record Nr.: UNINA9910784598203321
• Pubbl/distr/stampa: Amsterdam ; ; Boston : , : Elsevier, , 2006
• ISBN: 1-280-62899-5; 9786610628995; 0-08-046192-1
• Edizione: [First edition.]
• Descrizione fisica: 1 online resource (359 pages)
• Collana: Handbook of systemic autoimmune diseases ; ; v. 5
• Altri autori (Persone): Sarzi-PuttiniPiercarlo
• Disciplina: 616.5/079
• Soggetti: Skin - Diseases - Immunological aspects; Cutaneous manifestations of general diseases; Autoimmune diseases
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Preface; Series Editor; Volume Editors; List of Contributors; Contents; The Skin and the Immune System; The Skin as an Immunologic Organ; Introduction: the skin as an organ of defence; Evolving concepts of the skin as an immunological organ; The skin immune system; Immune responses in skin; Conclusions; Key points; References; T Cells and Dendritic Cells in Immuno-Mediated Skin Pathology; Introduction; Self-reactive T cell subsets; Dendritic cells-key regulators of immune responses; Dendritic cells in mixed connective tissue disease; Dendritic cells in Sjögren's syndrome; Dendritic cells induce psoriasis Acknowledgments; References; D6 as a Decoy and Scavenger Receptor for Inflammatory CC Chemokines in the Skin; Introduction; Expression and ligand recognition by the D6 chemokine decoy receptor; In vitro properties; D6 as a decoy in the skin; Concluding remarks; Key points; References; Autoantibodies and Skin Involvement in Systemic Autoimmune Diseases; Introduction; Autoantibodies in Systemic Sclerosis (SSc); Pathogenic autoantibodies; Anti-fibroblast antibodies; Anti-endothelial antibodies; Anti-matrix metalloproteinase (MMP) antibodies; Prognostic autoantibodies Pathogenic autoantibodies in systemic lupus ; erythematosus: the anti-Ro/SSA model; Clinical and pathogenic associations; Prognostic autoantibodies in other systemic autoimmune diseases; Dermatomyositis (DM); Other myositis; Rheumatoid arthritis (RA); Key points; References; Skin Involvement in Systemic Autoimmune Diseases; Photosensitivity in Lupus Erythematosus; Introduction; Pathophysiology of photosensitivity in LE; Clinical photosensitivity and phototesting; References; Cutaneous Manifestations of Lupus Erythematosus; Introduction; Specific cutaneous manifestations of lupus erythematosus Acute cutaneous lupus erythematosus; Subacute cutaneous lupus erythematosus; Chronic cutaneous lupus erythematosus; Discoid lupus erythematosus; Chilblain lupus erythematosus; Lupus erythematosus profundus; Intermittent cutaneous lupus erythematosus; Lupus erythematosus tumidus; Non-specific cutaneous manifestations of lupus erythematosus; Bullous skin lesions in lupus erythematosus; Urticarial Vasculitis; Papulonodular mucinosis; Annular erythema; Conclusions; Acknowledgements; Key points; References; Subacute Cutaneous Lupus Erythematosus: A Quarter Century's Perspective Introduction and historical perspective; Epidemiology; Incidence and prevalence; Demographics; Environmental influences; Etiology/pathogenesis; Clinical manifestations; Clinical features; Association with other forms of cutaneous LE and LE nonspecific skin disease; Association with SLE; Association with other autoimmune diseases; SCLE as a paraneoplastic phenomenon; Diagnostic investigations; Serology/immunology; Other laboratory features; Differential diagnosis; Treatment; Protection from ultraviolet light; Physical protection
• Sommario/riassunto: This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects.