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1. |
Record Nr. |
UNINA9910144228403321 |
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Titolo |
Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff |
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Pubbl/distr/stampa |
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Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
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©2008 |
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ISBN |
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1-281-94698-2 |
9786611946982 |
3-527-62267-5 |
3-527-62268-3 |
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Descrizione fisica |
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1 online resource (542 p.) |
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Disciplina |
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Soggetti |
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Drug development |
Drug development - Simulation methods |
Electronic books. |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Biosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction |
2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic β-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 |
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Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) |
3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results |
3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models |
4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling |
5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling |
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Sommario/riassunto |
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This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms.Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial dru |
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2. |
Record Nr. |
UNINA9910784587503321 |
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Autore |
Brovkin Vladimir N. |
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Titolo |
Russia after Lenin : politics, culture and society, 1921-1929 / / Vladimir Brovkin |
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Pubbl/distr/stampa |
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London ; ; New York : , : Routledge, , 1998 |
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ISBN |
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1-134-68057-0 |
1-134-68058-9 |
1-280-14414-9 |
0-203-97933-8 |
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Descrizione fisica |
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1 online resource (284 p.) |
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Disciplina |
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Soggetti |
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Soviet Union History 1917-1936 |
Soviet Union Politics and government 1917-1936 |
Soviet Union Civilization |
Soviet Union Social conditions 1917-1945 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references (p. [252]-259) and index. |
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Nota di contenuto |
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Book Cover; Half-Title; Title; Copyright; Dedication; Contents; Illustrations; Abbreviations; Acknowledgments; Introduction Revolutionary identity; Chapter 1 Extracting socially alien elements; Chapter 2 The Culture of the New Elite 1921–5 Ascetic knights and drinking pals; Chapter 3 Bolshevik actions and peasants' reactions, 1921–5 Face the village, face defeat; Chapter 4 Propaganda and popular belief; Chapter 5 The Komsomol and youth A transmission belt that snapped; Chapter 6 Women: false promises, dashed hopes, and the pretense of emancipation |
Chapter 7 Towards showdown in the countryside, 1926–8Chapter 8 The proletariat against the vanguard; Chapter 9 The Bolshevik old guard and the upstarts, 1924–9; Chapter 10 Conclusion; Notes; Bibliography; Index; |
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Sommario/riassunto |
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By examining the contrast between Bolshevik propaganda claims and social reality, Brovkin explains how Communist representations were variously received and resisted by workers, peasants, students, women, teachers and party officials. He presents a picture of cultural diversity |
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and rejection of Communist constraints through many means including unauthorized protest, religion, jazz music and poetry. Brovkin argues that these trends endangered the Communist Party's monopoly on political power and argues that the Stalinist revolution can be seen as a preemptive strike against this independent and |
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