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1. |
Record Nr. |
UNINA9910784046303321 |
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Autore |
Cristescu N |
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Titolo |
Dynamic plasticity [[electronic resource] /] / By N. Cristescu |
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Pubbl/distr/stampa |
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Amsterdam, : North-Holland Pub. Co., 2007 |
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ISBN |
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1-281-12085-5 |
9786611120856 |
981-270-760-3 |
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Descrizione fisica |
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1 online resource (481 p.) |
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Collana |
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North-Holland series in applied mathematics and mechanics ; ; v. 4 |
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Disciplina |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Rewritten and expanded edition of Probleme dinamice {circ}in teoria plastic{breve}a©ıtii, Bucharest, 1958. |
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Nota di bibliografia |
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Includes bibliography: p. [580]-608. |
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Nota di contenuto |
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Preface; Contents; Introduction; 1. Yield Conditions; 2. Rocks and Soils; 3. The Propagation of Longitudinal Stress Waves in Thin Bars; 4. Rate Influence; 5. Mechanics of Extensible Strings; 6. Flow of a Bigham Fluid; 7. Axi-Symmetrical Problems; 8. Plastic Waves. Perforation; 9. Hypervelocity Impact (Information); Author Index; Subject Index |
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Sommario/riassunto |
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This book presents a self-contained and comprehensive look at the field of dynamic plasticity for researchers and graduates in mechanical engineering. Drawing on the author's long career in the field, the book greatly extends material from the 1967 original edition with the addition of fresh research chapters as well as a full introduction to the elementary theory of plasticity. The coverage of new areas includes a chapter on rocks and soils, the various developments in research on rate type, and novel problems concerning non-homogenous Bingham fluids, such as flow along an inclined slope. Oth |
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2. |
Record Nr. |
UNINA9911053032003321 |
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Titolo |
Updates on Molecular Targeted Therapies for CNS Tumors |
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Pubbl/distr/stampa |
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MDPI - Multidisciplinary Digital Publishing Institute, 2023 |
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Descrizione fisica |
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1 online resource (368 p.) |
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Soggetti |
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Medicine and Nursing |
Oncology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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The challenges in identifying effective therapies for CNS tumors continue to be daunting. Potentially effective targeted therapies must be able to penetrate the blood-brain barrier to reach the tumor and, in sufficient concentrations, to result in meaningful treatment responses. Moreover, molecular targets must be key drivers in the growth and progression of CNS tumors. Numerous potentially efficacious therapies have failed in randomized clinical trials due to other factors, including subclonal genetic intratumoral heterogeneity (particularly within malignant gliomas), epigenetic heterogeneity, and failure to target important factors involved in the tumor microenvironment. Developing effective targeted therapies requires a thorough fundamental understanding of the genetic and epigenetic factors driving tumor progression, the interactions between CNS tumor cells and the tumor microenvironment, and the key mechanisms of tumor treatment resistance. In this Special Issue, experts in the field of CNS tumors will highlight the most promising molecular targets in the development of treatments for patients with CNS tumors. |
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