1.

Record Nr.

UNINA9910783846803321

Titolo

Signalling pathways in apoptosis / / edited by Dianne Watters and Martin Lavin

Pubbl/distr/stampa

Amsterdam : , : Harwood Academic, , 1999

ISBN

0-429-17691-0

1-4822-9821-X

1-280-07171-0

9786610071715

0-203-30365-2

Descrizione fisica

1 online resource (338 p.)

Collana

Modern genetics, , 1056-4497 ; ; v. 5

Altri autori (Persone)

LavinMartin <1943->

WattersDianne <1952->

Disciplina

571.936

Soggetti

Apoptosis

Cellular signal transduction

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references and index.

Nota di contenuto

Book Cover; Title; Contents; Preface to the Series; Preface; Contributors; Overview: A Matter of Life and Death; The Death Receptors; The Role of Sphingolipids in Stress Responses and Apoptosis in Eukaryotes; Radiation Response Pathways and Apoptosis; Kinase Cascades and Apoptosis; Protein Kinase C Isoenzymes: Evidence for Selectivity in the Regulation of Apoptosis; Apoptosis in Drosophila; Baculoviral Lessons in Apoptosis; The Mitochondrion: Decisive for Cell Death Control?; Caspases and the Commitment to Death; Caspases: The Molecular Effectors of Apoptosis; Killer Cells

Deliverers of Exogenous Death ProteasesSubstrates of Cell Death Proteases and their Role in Apoptosis; Index

Sommario/riassunto

Apoptosis, or programmed cell death, is a necessary process by which a cell may die without adversely affecting its environment. It plays a crucial role in normal development, and in the body's defence mechanisms against disease. Too much cell death is destructive, leading to neurodegenerative diseases and impaired development. Conversely, too little cell death can lead to an increased susceptibility



to cancer and sustained viral infection. Apoptosis is a matter of balanceDramatic progress has been made in the study of apoptosis over the past decade. One of the most rapidly expanding knowl