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1. |
Record Nr. |
UNINA9910139613803321 |
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Autore |
Kazmierski Wieslaw M |
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Titolo |
Antiviral Drugs [[electronic resource] ] : From Basic Discovery Through Clinical Trials |
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Pubbl/distr/stampa |
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ISBN |
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1-283-20363-4 |
9786613203632 |
0-470-92935-9 |
0-470-92934-0 |
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Descrizione fisica |
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1 online resource (470 p.) |
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Disciplina |
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Soggetti |
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Antiviral Agents -- therapeutic use |
Antiviral agents |
Clinical Trials as Topic |
Drug Discovery |
Drug Evaluation |
Epidemiologic Studies |
Chemistry, Pharmaceutical |
Evaluation Studies as Topic |
Investigative Techniques |
Anti-Infective Agents |
Epidemiologic Methods |
Pharmacology |
Therapeutic Uses |
Health Care Evaluation Mechanisms |
Chemistry |
Biological Science Disciplines |
Natural Science Disciplines |
Quality of Health Care |
Public Health |
Pharmacologic Actions |
Environment and Public Health |
Health Care Quality, Access, and Evaluation |
Chemical Actions and Uses |
Health Care |
Antiviral Agents |
Health & Biological Sciences |
Pharmacy, Therapeutics, & Pharmacology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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ANTIVIRAL DRUGS; CONTENTS; CONTRIBUTORS; PREFACE; PART I HUMAN IMMUNODEFICIENCY VIRUS; 1 Discovery and Development of Atazanavir; 2 Discovery and Development of PL-100, A Novel HIV-1 Protease Inhibitor; 3 Darunavir (Prezista, TMC114): From Bench to Clinic, Improving Treatment Options for HIV-Infected Patients; 4 Discovery and Development of Tipranavir; 5 TMC278 (Rilpivirine): A Next-Generation NNRTI in Phase III Clinical Development for Treatment-Naive Patients; 6 Etravirine: From TMC125 to Intelence: A Treatment Paradigm Shift for HIV-Infected Patients |
7 Discovery and Development of Tenofovir Disoproxil Fumarate8 Discovery and Development of Apricitabine; 9 Discovery and Development of Maraviroc and PF-232798: CCR5 Antagonists for the Treatment of HIV-1 Infection; 10 Discovery of the CCR5 Antagonist Vicriviroc (Sch 417690/Sch-D) for the Treatment of HIV-1 Infection; 11 Discovery and Development of HIV-1 Entry Inhibitors That Target gp120; 12 Discovery of MK-0536: A Potential Second-Generation HIV-1 Integrase Strand Transfer Inhibitor with a High Genetic Barrier to Mutation; 13 Discovery and Development of HIV Integrase Inhibitor Raltegravir |
14 Elvitegravir: A Novel Monoketo Acid HIV-1 Integrase Strand Transfer InhibitorPART II HEPATITIS C VIRUS; 15 Discovery and Development of Telaprevir; 16 Discovery and Development of BILN 2061 and Follow-up BI 201335; 17 Intervention of Hepatitis C Replication Through NS3-4A, the Protease Inhibitor Boceprevir; 18 Discovery and Development of the HCV NS3/4A Protease Inhibitor Danoprevir (ITMN-191/RG7227); 19 Discovery and Development of the HCV Protease Inhibitor TMC435; 20 Discovery and Clinical Evaluation of the Nucleoside Analog Balapiravir (R1626) for the Treatment of HCV Infection |
21 Discovery and Development of PSI-6130/RG712822 Discovery of Cyclophilin Inhibitor NIM811 as a Novel Therapeutic Agent for HCV; 23 HCV Viral Entry Inhibitors; PART III RESPIRATORY SYNCYTIAL VIRUS INHIBITORS; 24 Discovery of the RSV Inhibitor TMC353121; 25 Discovery and Development of Orally Active RSV Fusion Inhibitors; 26 Discovery and Development of RSV604; PART IV INFLUENZA, HEPATITIS B, AND CYTOMEGALOVIRUS INHIBITORS; 27 Discovery and Development of Influenza Virus Sialidase Inhibitor Relenza; 28 Discovery and Development of Entecavir |
29 Benzimidazole Ribonucleosides: Novel Drug Candidates for the Prevention and Treatment of Cytomegalovirus DiseasesINDEX; Color Plate |
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Sommario/riassunto |
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This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense so |
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2. |
Record Nr. |
UNINA9910783754503321 |
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Titolo |
Bilingualism and language pedagogy [[electronic resource] /] / edited by Janina Brutt-Griffler and Manka Varghese |
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Pubbl/distr/stampa |
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Clevedon ; ; Buffalo, : Multilingual Matters, c2004 |
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ISBN |
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1-280-73937-1 |
9786610739370 |
1-85359-756-2 |
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Descrizione fisica |
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Collana |
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Bilingual education and bilingualism ; ; 47 |
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Altri autori (Persone) |
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Brutt-GrifflerJanina <1966-> |
VargheseManka <1969-> |
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Disciplina |
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Soggetti |
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Bilingualism |
Education, Bilingual |
Language and languages - Study and teaching |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Front matter -- Contents -- Introduction -- Between Support and Marginalisation: The Development of Academic Language in Linguistic Minority Children -- Spanish/English Speech Practices: Bringing Chaos to Order -- The Continua of Biliteracy and the Bilingual Educator: Educational Linguistics in Practice -- Teacher Identity as Pedagogy: Towards a Field-Internal Conceptualisation in Bilingual and Second Language Education -- Bilingual Teachers in Mainstream Secondary School Classrooms: Using Turkish for Curriculum Learning -- Do We Expect Too Much of Bilingual Teachers? Bilingual Teaching in Developing Countries -- Professional Development for Bilingual Teachers in the United States: A Site for Articulating and Contesting Professional Roles |
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Sommario/riassunto |
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Bilingualism and Language Pedagogy brings an understanding of language as a social practice, and bilingualism as the study of bidirectional transitioning, to the examination of bilingual settings in the US, Europe and developing countries. The volume suggests that language pedagogy needs to reflect new understandings of bilinguals. Focusing both on bilingual linguistic competence and educational |
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politics and practice, the chapters provide valuable practical proposals and models for developing sociocultural and linguistic competencies among bilingual practitioners and students. The volume situates teachers as mediators and explores the key roles that they have as language and content educators. In discussing the experiences of learners, it takes up the linguistic competence of bilinguals, highlighting how their language use constitutes a resource for meeting the demands of social interactions, and foregrounds the significance of developing academic language proficiency in English among minority children to decrease the barriers facing them in residential and academic settings. |
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