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1. |
Record Nr. |
UNINA9910782908803321 |
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Autore |
Samson Jim |
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Titolo |
Virtuosity and the musical work : the Transcendental studies of Liszt / / Jim Samson [[electronic resource]] |
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Pubbl/distr/stampa |
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Cambridge : , : Cambridge University Press, , 2003 |
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ISBN |
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1-107-13391-2 |
1-280-43417-1 |
0-511-17891-3 |
0-511-04253-1 |
0-511-14887-9 |
0-511-32374-3 |
0-511-48196-9 |
0-511-04570-0 |
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Descrizione fisica |
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1 online resource (viii, 240 pages) : digital, PDF file(s) |
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Disciplina |
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Soggetti |
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Music - 19th century - History and criticism |
Virtuosity in musical performance |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Title from publisher's bibliographic system (viewed on 05 Oct 2015). |
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Nota di bibliografia |
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Includes bibliographical references (p. 227-234) and index. |
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Nota di contenuto |
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1. Ecology by numbers -- 2. Of maps and materials -- 3. Composing the performance -- 4. Making and remaking -- 5. Forms and reforms -- 6. Suggestion and symbol -- 7. Mazeppa times 7. |
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Sommario/riassunto |
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This book is about three sets of etudes by Liszt: the Etude en douze exercices (1826), its reworking as Douzes grandes études (1837), and their reworking as Douzes études d'exécution transcendante (1851). At the same time it is a book about nineteenth-century instrumental music in general, in that the three works invite the exploration of features characteristic of the early Romantic era in music. These include: a composer-performer culture, the concept of virtuosity, the significance of recomposition, music and the poetic, and the consolidation of a musical work-concept. A central concern is to illuminate the relationship between the work-concept and a performance- and genre-orientated musical culture. At the same time |
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the book reflects on how we might make judgements of the 'Transcendentals', of the Symphonic Poem Mazeppa (based on the fourth etude), and of Liszt's music in general. |
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2. |
Record Nr. |
UNINA9910253959203321 |
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Titolo |
Uptake and Trafficking of Protein Toxins / / edited by Holger Barth |
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Pubbl/distr/stampa |
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Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
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ISBN |
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Edizione |
[1st ed. 2017.] |
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Descrizione fisica |
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1 online resource (VII, 256 p.) |
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Collana |
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Current Topics in Microbiology and Immunology, , 0070-217X ; ; 406 |
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Disciplina |
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Soggetti |
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Medical microbiology |
Pharmacology |
Infectious diseases |
Medical Microbiology |
Pharmacology/Toxicology |
Infectious Diseases |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references at the end of each chapters. |
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Nota di contenuto |
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Two feet on the membrane: uptake of clostridial neurotoxins -- Receptors and binding structures for Clostridium difficile Toxins A and B -- Cell entry of C3 exoenzyme from Clostridium botulinum.- Receptor-binding and up-take of binary actin-ADP-ribosylating toxins -- Clostridial Binary Toxins: Basic Understandings that Include Cell-Surface Binding and an Internal “Coup de Grace” -- Host cell chaperones Hsp70/Hsp90 and peptidyl-prolyl cis/trans isomerases are required for the membrane translocation of bacterial ADP-ribosylating toxins -- Multivalent Inhibitors of Channel-Forming Bacterial Toxins -- Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and its inhibition by Positively Charged Heterocyclic Molecules. |
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Sommario/riassunto |
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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological |
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strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists. |
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