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Record Nr. |
UNINA9910782552403321 |
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Titolo |
Developing solid oral dosage forms : pharmaceutical theory and practice / / executive editors, Yihong Qiu, Yisheng Chen, Geoff G.Z. Zhang ; associate editors, Linong Liu, William R. Porter |
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Pubbl/distr/stampa |
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Amsterdam ; ; Boston ; ; London, : Academic, 2009 |
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ISBN |
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1-282-73750-3 |
9786612737503 |
0-08-093272-X |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (976 pages) |
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Altri autori (Persone) |
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QiuYihong |
ChenYisheng (Of Novast Laboratories) |
ZhangGeoff G. Z |
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Disciplina |
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Soggetti |
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Solid dosage forms |
Solid dosage forms - Research |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Front Cover; Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice; Copyright Page; Contents; List of Contributors; Foreword; PART I: THEORIES AND TECHNIQUES IN THE CHARACTERIZATION OF DRUG SUBSTANCES AND EXCIPIENTS; Chapter 1. Solubility of Pharmaceutical Solids; 1.1 Introduction; 1.1.1 Implication of Solubility in Dosage Form Development; 1.1.2 Basic Concepts of Solubility and Dissolution; 1.2 Thermodynamics of Solutions; 1.2.1 Volume of Mixing; 1.2.2 Enthalpy of Mixing; 1.2.3 Entropy of Mixing; 1.2.4 Free Energy of Mixing; 1.3 Theoretical Estimation of Solubility |
1.3.1 Ideal Solutions; 1.3.2 Effect of Crystallinity; 1.3.3 Non-ideal Solutions; 1.3.4 Regular Solution Theory; 1.3.5 Aqueous Solution Theory; 1.3.6 The General Solubility Equation (GSE); 1.4 Solubilization of Drug Candidates; 1.4.1 Solubility Enhancement by pH Control and Salt Formation; 1.4.2 Solubilization Using Complexation; 1.4.3 Solubilization by Cosolvents; 1.4.4 Solubilization by Surfactants (Micellar Solubilization); 1.4.5 Solubilization by Combination of |
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