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1. |
Record Nr. |
UNINA9910782218303321 |
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Autore |
Tinsley Matthew |
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Titolo |
Asperger syndrome and alcohol [[electronic resource] ] : drinking to cope? / / Matthew Tinsley and Sarah Hendrickx ; foreword by Temple Grandin |
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Pubbl/distr/stampa |
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London ; ; Philadelphia, : Jessica Kingsley Publishers, 2008 |
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ISBN |
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1-281-78242-4 |
9786611782429 |
1-84642-814-9 |
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Descrizione fisica |
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1 online resource (143 p.) |
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Collana |
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Adults speak out about Asperger syndrome |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Asperger's syndrome - Patients - Alcohol use |
Dual diagnosis |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Asperger syndrome and alcohol: why should there be a link? -- Childhood and adolescence: where does it start? -- The adult social world: friendship, relationships and other people -- Employment: drinking and the workplace -- Beginning of the end: a failing strategy -- Drying out: support and rehabilitation -- Life beyond the booze: recovering autistic alcoholic. |
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2. |
Record Nr. |
UNINA9910796550803321 |
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Titolo |
Giovenale tra storia, poesia e ideologia / / Antonio Stramaglia, Stefano Grazzini, Giuseppe Dimatteo |
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Pubbl/distr/stampa |
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Berlin ; ; Boston : , : De Gruyter, , [2016] |
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©2016 |
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ISBN |
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3-11-048497-8 |
3-11-048619-9 |
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Descrizione fisica |
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1 online resource (VIII, 357 p.) |
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Collana |
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Beiträge zur Altertumskunde ; ; 357 |
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Classificazione |
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Disciplina |
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Soggetti |
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Juvenal |
Lateinische Literatur |
Satire |
Latin literature |
satire |
LITERARY CRITICISM / Ancient & Classical |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Frontmatter -- Premessa -- Sommario -- Introduzione -- Cronologia e ideologia politica nelle satire di Giovenale -- La Roma di Giovenale (e il nido della Concordia in 1, 116) -- In medio venenum: una tipologia di parentesi in Giovenale -- Il ms. Cambridge, King’s College, 52 e la tradizione del testo di Giovenale -- Poetica e ideologia nella terza satira di Giovenale -- Umbricius, the Sybil and Evander: Vergilian voices in Juvenal, Satire 3 -- Tradizione satirica e memoria letteraria: Luciano lettore di Giovenale? -- Il fragmentum Antinoense e la fortuna di Giovenale nel mondo grecofono -- Libri e percorsi tardoantichi delle satire di Giovenale (e di Persio) -- Prejudice and obstinacy in brackets: Juvenal, Satire 6 and the Oxford fragment(s) -- Juvenal and declamatory inventio -- Proprietà terriere e metodi ‘mafiosi’: Iuv. 14, 138–151 -- Indice dei luoghi antichi -- Indice dei nomi e delle cose notevoli |
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Sommario/riassunto |
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Juvenal’s satire continues to fascinate his readers and to challenge scholars by the constant interplay of a strong poetical identity, a keen |
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historical perception, and an irresoluble ideological tension. The essays collected in this volume pursue these three strands from different but complementary perspectives, aiming at a firmer assessment of the character, the oeuvre, and the background of Rome’s last great satirical poet. |
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3. |
Record Nr. |
UNINA9910346737703321 |
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Autore |
Tommaso Pizzorusso |
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Titolo |
Regulatory RNAs in the Nervous System, 2nd Edition |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (346 p.) |
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Collana |
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Frontiers Research Topics |
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Soggetti |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating |
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cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential. |
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