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1. |
Record Nr. |
UNINA9910780934103321 |
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Titolo |
Dynamical aspects of nuclear fission [[electronic resource] ] : proceedings of the 6th International Conference, Smolenice Castle, Slovak Republic : 2-6 October 2006 / / editors, J. Kliman, M.G. Itkis, Š. Gmuca |
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Pubbl/distr/stampa |
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Singapore ; ; Hackensack, NJ, : World Scientific, c2008 |
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ISBN |
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1-282-44231-7 |
9786612442315 |
981-283-753-1 |
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Descrizione fisica |
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1 online resource (377 p.) |
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Altri autori (Persone) |
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KlimanJan |
ItkisM. G |
GmucaS̆ (Stefan) |
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Disciplina |
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Soggetti |
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Nuclear fission |
Nuclear reactions |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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DANF 2006 Conference Committee; Preface; CONTENTS; FISSION DYNAMICS; FUSION·FISSION; SUPERHEA VY ELEMENTS; FRAGMENTATION; EXOTIC MODES; STRUCTURE OF FISSION FRAGMENTS AND NEURTON RICH NUCLEI; DEVELOPMENTS IN EXPERIMENTAL TECHNIQUES; List of participants; Author index |
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Sommario/riassunto |
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This proceedings volume is sixth in the series of international conferences covering the fission, quasi-fission, fusion-fission phenomena and synthesis of superheavy nuclei, mainly at low or near barrier energies. Both experimental and theoretical issues are covered. The topics are discussed by a group of participants, and an overview of the current activities in the field is given. |
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2. |
Record Nr. |
UNINA9910811243903321 |
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Titolo |
GPCR molecular pharmacology and drug targeting : shifting paradigms and new directions / / edited by Annette Gilchrist |
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Pubbl/distr/stampa |
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Hoboken, N.J., : Wiley, c2010 |
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ISBN |
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9786612685996 |
9781118035177 |
1118035178 |
9781282685994 |
1282685996 |
9780470627327 |
0470627328 |
9780470627310 |
047062731X |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (544 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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G proteins |
Drug targeting |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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GPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING: SHIFTING PARADIGMS AND NEW DIRECTIONS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: The Evolution of Receptors: From On-Off Switches to Microprocessors; CHAPTER 2: The Evolving Pharmacology of GPCRs; CHAPTER 3: The Emergence of Allosteric Modulators for G Protein - Coupled Receptors; CHAPTER 4: Receptor-Mediated G Protein Activation: How, How Many, and Where?; CHAPTER 5: Molecular Pharmacology of Frizzleds-with Implications for Possible Therapy |
CHAPTER 6: Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled ReceptorsCHAPTER 7: Past and Future Strategies for GPCR Deorphanization; CHAPTER 8: High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype; CHAPTER 9: Are "Traditional" Biochemical Techniques Out of Fashion in the New Era of GPCR |
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Pharmacology?; CHAPTER 10: Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function; CHAPTER 11: Integration of Label-Free Detection Methods in GPCR Drug Discovery |
CHAPTER 12: Screening for Allosteric Modulators of G Protein-Coupled ReceptorsCHAPTER 13: Ultra-High-Throughput Screening Assays for GPCRs; CHAPTER 14: New Techniques to Express and Crystallize G Protein-Coupled Receptors; CHAPTER 15: Structure and Modeling of GPCRs: Implications for Drug Discovery; CHAPTER 16: X-Ray Structure Developments for GPCR Drug Targets; CHAPTER 17: Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors; INDEX |
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Sommario/riassunto |
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G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference. |
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