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1. |
Record Nr. |
UNINA9910780670703321 |
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Titolo |
Canadian annual review of politics and public affairs . 2000 / / edited by David Mutimer |
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Pubbl/distr/stampa |
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Toronto, [Ontario] ; ; Buffalo, [New York] ; ; London, [England] : , : University of Toronto Press, , 2006 |
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©2006 |
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ISBN |
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1-281-99196-1 |
9786611991968 |
1-4426-7213-7 |
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Descrizione fisica |
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1 online resource (328 p.) |
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Collana |
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Canadian Annual Review of Politics and Public Affairs |
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Disciplina |
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Soggetti |
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Public administration - Canada |
POLITICAL SCIENCE / Reference |
Electronic books. |
Canada Politics and government 20th century |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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""Contents""; ""Contributors""; ""Preface""; ""Canadian calendar""; ""Editor's introduction � the year in review""; ""The federal government, politics, and national institutions""; ""ELECTION 2000""; ""Early hints of a fall election""; ""Birth of the Canadian Conservative Reform Alliance""; ""A new day dawns""; ""By-elections: enter the leaders""; ""Fine-tuning the cabinet""; ""Crossing the floor: expulsions and defections""; ""The election call""; ""The field forms""; ""Parties and platforms""; ""On the hustings""; ""The debates""; ""Electoral outcome""; ""Fund-raising and expenditures"" |
""Aftermath""""NATIONAL INSTITUTIONS""; ""Senate""; ""Auditor General""; ""ECONOMIC INDICATORS AND ISSUES""; ""Economic indicators""; ""Budget 2000""; ""The mini-budget""; ""The Bank of Canada""; ""Shake-out in mass media and telecommunications""; ""Bailout for NHL teams?""; ""FEDERAL � PROVINCIAL RELATIONS""; ""The Clarity Bill""; ""Health-care accord""; ""MAJOR POLICY FIELDS""; ""A thin legislative agenda""; ""Airline industry rules""; ""Licensing of the |
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Canadian Broadcasting Corporation""; ""Same-sex legislation""; ""THE PASSING OF PIERRE TRUDEAU""; ""SCANDALS AND CONTROVERSIES"" |
""Management of Human Resources Development Canada""""The Prime Minister's riding""; ""Lawsuit against Mr Day""; ""Without peer: Mr Black's lawsuit against the Prime Minister""; ""Canada in the world: foreign affairs and national defence""; ""FOREIGN AFFAIRS""; ""United States""; ""Illegal immigration""; ""World Trade Organization""; ""Asia-Pacific""; ""Middle East""; ""Europe""; ""International summitry and the developing world""; ""United Nations and human security""; ""DEFENCE POLICY""; ""National missile defence""; ""Reform and personnel management""; ""Defence budget and procurement"" |
""CF operations of note""""Municipal affairs""; ""URBAN POLITICS AND LOCAL GOVERNMENT""; ""CITIES IN THE MARKETPLACE""; ""THE CULTURES OF CITIES""; ""REGIONAL GOVERNANCE""; ""LOCAL DEMOCRACY""; ""CITIES IN CONFEDERATION""; ""British Columbia""; ""PREMIER DOSANJH""; ""MR CLARK ON TRIAL""; ""MR CAMPBELL IN QUESTION""; ""SPEECH FROM THE THRONE""; ""HEALTH""; ""FORESTS""; ""BALANCED-BUDGET LAW""; ""NATURAL RESOURCES""; ""WILDLIFE""; ""ECONOMY""; ""Alberta""; ""BILL 11""; ""ENERGY AND REBATES: POWER POLITICS IN ACTION""; ""THE FLAT TAX BECOMES REALITY""; ""THE LEGISLATURE"" |
""STOCKWELL DAY GOES NATIONAL""""THE FEDERAL ELECTION IN ALBERTA""; ""THE PARTIES""; ""THE ECONOMY""; ""MISCELLANEOUS""; ""Saskatchewan""; ""ELECTIONS""; ""Provincial by-election""; ""Federal election""; ""Municipal elections""; ""PROVINCIAL POLITICAL PARTIES""; ""New Democratic Party""; ""Liberal Party""; ""Saskatchewan Party""; ""Conservative Party""; ""Aboriginal parties""; ""FEDERAL POLITICAL PARTIES""; ""Liberal Party""; ""New Democratic Party""; ""Alliance Party""; ""Progressive Conservative Party""; ""THE LEGISLATURE AND GOVERNMENT""; ""The executive""; ""The Legislature"" |
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Sommario/riassunto |
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Long praised for its accuracy, readability, and insight, the Canadian Annual Review of Politics and Public Affairs offers a synoptic appraisal of the year's developments in Canadian politics. The first year of the new millennium saw a new conservative federal party born with the union of the Reform Party and disaffected federal Progressive Conservatives. Led by Stockwell Day, the Canadian Alliance was defeated by Jean Chretien's Liberals in the subsequent federal election. A second RCMP investigation into questionable job-creation grants in Chretien's home riding, however, hurt the Prime Minister's reputation. The Liberals' new cigarette-packaging requirements, featuring gruesome tobacco-related images meant to discourage smoking, were challenged by tobacco companies. As well, the issue of police racism was brought to the fore when two Saskatoon police officers were suspended over allegations they abandoned a Native man on a cold winter night without a coat. Additionally, Ontario's chief coroner announced an investigation into the deaths of nine people following an outbreak of E. Coli in Walkerton. The Canadian Annual Review is unique in its collection and presentation of the year in politics. The combination of the calendar and the text offers a superb, easy-access reference source for political events, both federal and provincial. |
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2. |
Record Nr. |
UNINA9910808713803321 |
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Autore |
Kazmierski Wieslaw M |
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Titolo |
Antiviral Drugs : From Basic Discovery Through Clinical Trials |
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Pubbl/distr/stampa |
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ISBN |
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1-283-20363-4 |
9786613203632 |
0-470-92935-9 |
0-470-92934-0 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (470 p.) |
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Disciplina |
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Soggetti |
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Antiviral Agents -- therapeutic use |
Antiviral agents |
Clinical Trials as Topic |
Drug Discovery |
Drug Evaluation |
Epidemiologic Studies |
Chemistry, Pharmaceutical |
Evaluation Studies as Topic |
Investigative Techniques |
Anti-Infective Agents |
Epidemiologic Methods |
Pharmacology |
Therapeutic Uses |
Health Care Evaluation Mechanisms |
Chemistry |
Biological Science Disciplines |
Natural Science Disciplines |
Quality of Health Care |
Public Health |
Pharmacologic Actions |
Environment and Public Health |
Health Care Quality, Access, and Evaluation |
Chemical Actions and Uses |
Delivery of Health Care |
Antiviral Agents |
Health & Biological Sciences |
Pharmacy, Therapeutics, & Pharmacology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di contenuto |
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ANTIVIRAL DRUGS; CONTENTS; CONTRIBUTORS; PREFACE; PART I HUMAN IMMUNODEFICIENCY VIRUS; 1 Discovery and Development of Atazanavir; 2 Discovery and Development of PL-100, A Novel HIV-1 Protease Inhibitor; 3 Darunavir (Prezista, TMC114): From Bench to Clinic, Improving Treatment Options for HIV-Infected Patients; 4 Discovery and Development of Tipranavir; 5 TMC278 (Rilpivirine): A Next-Generation NNRTI in Phase III Clinical Development for Treatment-Naive Patients; 6 Etravirine: From TMC125 to Intelence: A Treatment Paradigm Shift for HIV-Infected Patients |
7 Discovery and Development of Tenofovir Disoproxil Fumarate8 Discovery and Development of Apricitabine; 9 Discovery and Development of Maraviroc and PF-232798: CCR5 Antagonists for the Treatment of HIV-1 Infection; 10 Discovery of the CCR5 Antagonist Vicriviroc (Sch 417690/Sch-D) for the Treatment of HIV-1 Infection; 11 Discovery and Development of HIV-1 Entry Inhibitors That Target gp120; 12 Discovery of MK-0536: A Potential Second-Generation HIV-1 Integrase Strand Transfer Inhibitor with a High Genetic Barrier to Mutation; 13 Discovery and Development of HIV Integrase Inhibitor Raltegravir |
14 Elvitegravir: A Novel Monoketo Acid HIV-1 Integrase Strand Transfer InhibitorPART II HEPATITIS C VIRUS; 15 Discovery and Development of Telaprevir; 16 Discovery and Development of BILN 2061 and Follow-up BI 201335; 17 Intervention of Hepatitis C Replication Through NS3-4A, the Protease Inhibitor Boceprevir; 18 Discovery and Development of the HCV NS3/4A Protease Inhibitor Danoprevir (ITMN-191/RG7227); 19 Discovery and Development of the HCV Protease Inhibitor TMC435; 20 Discovery and Clinical Evaluation of the Nucleoside Analog Balapiravir (R1626) for the Treatment of HCV Infection |
21 Discovery and Development of PSI-6130/RG712822 Discovery of Cyclophilin Inhibitor NIM811 as a Novel Therapeutic Agent for HCV; 23 HCV Viral Entry Inhibitors; PART III RESPIRATORY SYNCYTIAL VIRUS INHIBITORS; 24 Discovery of the RSV Inhibitor TMC353121; 25 Discovery and Development of Orally Active RSV Fusion Inhibitors; 26 Discovery and Development of RSV604; PART IV INFLUENZA, HEPATITIS B, AND CYTOMEGALOVIRUS INHIBITORS; 27 Discovery and Development of Influenza Virus Sialidase Inhibitor Relenza; 28 Discovery and Development of Entecavir |
29 Benzimidazole Ribonucleosides: Novel Drug Candidates for the Prevention and Treatment of Cytomegalovirus DiseasesINDEX; Color Plate |
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Sommario/riassunto |
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This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense so |
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