1.

Record Nr.

UNINA9910779527303321

Titolo

DNA replication and mutation [[electronic resource] /] / Raymond P. Leitner, editor

Pubbl/distr/stampa

Hauppauge, NY, : Nova Science, 2012

ISBN

1-61942-455-X

Descrizione fisica

1 online resource (204 p.)

Collana

DNA and RNA

Altri autori (Persone)

LeitnerRaymond P

Disciplina

572.8/645

Soggetti

DNA replication

DNA - Synthesis

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

Description based upon print version of record.

Nota di bibliografia

Includes bibliographical references (p. 158-177) and index.

Nota di contenuto

""DNA REPLICATIONAND MUTATION""; ""DNA AND RNA: PROPERTIESAND MODIFICATIONS, FUNCTIONSAND INTERACTIONS, RECOMBINATIONAND APPLICATIONS""; ""Library of Congress Cataloging-in-Publication Data""; ""Contents""; ""Preface""; ""Connections between BLMand the Fanconi AnemiaPathway in the Repair ofReplication Fork Damage""; ""Abstract""; ""RecQ DNA Helicases""; ""BLM and Regulationof Homologous Replication""; ""Connections between FANCM of the FanconiAnemia Pathway and BLM""; ""Connections between FANCJ of the FAPathway and BLM""

""The Structure-Specific EndonucleaseSLX4-SLX1 and Its Relationshipto BLM and the FA Pathway""""Conclusion""; ""Acknowledgments""; ""References""; ""Mutagenic Potentialof Methacrylates Usedin Restorative Dentistry""; ""Abstract""; ""Introduction""; ""Materials and Methods""; ""Chemicals""; ""Cells""; ""Cell Treatment""; ""Cell Viability""; ""Plasmid Relaxation Assay""; ""Comet Assay""; ""Oxidative Damage to DNA""; ""DNA Double-Strand Breaks Assays""; ""Apoptosis""; ""Cell Cycle""; ""Data Analysis""; ""Results""; ""Cell Viability""; ""DNA Damage In Vitro""

""DNA Damage in Human Gingival Fibroblasts""""DNA Double-Strand Breaks""; ""DNA Repair""; ""Oxidative Modifications to the DNA Bases""; ""Apoptosis""; ""Cell Cycle""; ""Discussion""; ""Acknowledgments""; ""Conflict of Interest Statement""; ""References""; ""DNA Mutation of theProgranulin (GRN) Gene inFamilial Frontotemporal



LobarDegeneration (FTLD): A Studyof the Pathology of Nine Cases""; ""Abstract""; ""Introduction""; ""Heterogeneity of FTLD-TDP""; ""DNA Mutations""; ""Objectives""; ""Materials and Methods""; ""Cases""; ""Histological Methods""; ""Morphometric Measurements""

""Measurement of Density of Inclusions""""Spatial Patterns of the Inclusions""; ""Laminar Distribution""; ""Density of TDP-43Immunoreactive Inclusions""; ""Spatial Patterns of TDP-43Immunoreactive Inclusions""; ""Laminar Distribution of TDP-43Immunoreactive Inclusions""; ""Conclusion""; ""Acknowledgments""; ""References""; ""Effect of a Specific MammalianDNA Polymerase α-Inhibitor,Dehydroaltenusin, on DNAReplication in Cultured Cells""; ""Abstract""; ""Abbreviations""; ""1. Introduction""; ""2. Production and Isolationof Dehydroaltenusin""

""3. Effect of Dehydroaltenusin on Polsand other DNA Metabolic Enzymes""""4. Mode of Pol α Inhibitionby Dehydroaltenusin""; ""5. Effect of Dehydroaltenusinon Human Cancer Cell Growth""; ""6. Inhibitory Properties of ehydroaltenusinon Human Cancer Cell Growth""; ""7. Effect of Dehydroaltenusin on DNAReplication in NIH3T3 Cells""; ""8. Discussion""; ""Conclusion""; ""Acknowledgments""; ""References""; ""Gel-Based Methods Using DNABindingZinc(II) Complexesfor the Detectionof DNA Mutations""; ""Abstract""; ""Introduction""; ""Zinc(II)�Cyclen""

""Zinc(II)�Cyclen PolyacrylamideGel Electrophoresis""