Granulocytes [[electronic resource] ] : production, types, and roles in disease / / Hisao Abukara and Michi Jumonji, editors

• Record Nr.: UNINA9910779506803321
• Pubbl/distr/stampa: New York, : Nova Science Publisher's, Inc., c2012
• ISBN: 1-61942-812-1
• Descrizione fisica: 1 online resource (156 p.)
• Collana: Cell biology research progress; Microbiology research advances
• Altri autori (Persone): AbukaraHisao; JumonjiMichi
• Disciplina: 616.07/99
• Soggetti: Granulocytes; Granulocytes - Diseases
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: ""GRANULOCYTES""; ""GRANULOCYTES""; ""CONTENTS ""; ""PREFACE ""; ""REGULATION OF GRANULOCYTE DIFFERENTIATION BY MICRO-RNA AND TRANSCRIPTION FACTORS â€? LESSONS LEARNED FOR UNDERSTANDING HEMATOPOIETIC DISEASES ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""BIOSYNTHESIS AND REGULATION OF MICRO-RNA IN MAMMALIAN CELLS""; ""GENERAL MECHANISMS OF GRANULOPOIESIS AND REGULATION BY TRANSCRIPTION FACTORS ""; ""MIRNA â€? ONE OF THE GATE KEEPER IN GRANULOPOIESIS ""; ""MIRNA â€? A CONTRIBUTOR TO MYELOID MALIGNANCIES AND A POTENT TOOL FOR PROGNOSIS AND CLASSIFICATION ""; ""CONCLUDING REMARKS ""; ""BIBLIOGRAPHY """"THE ESSENTIAL TRANSCRIPTION FACTOR FOR GRANULOCYTIC DIFFERENTIATION, CCAAT/ENHANCER BINDING PROTEIN ALPHA (C/EBPÎ?), AND ITS MUTATIONS OR INHIBITION ASSOCIATED WITH ACUTE MYELOID LEUKEMIAS ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""STRUCTURE AND FUNCTION OF C/EBPÎ? ""; ""CEBPA Gene and C/EBPα mRNA ""; ""Transcription Factor C/EBPα ""; ""The Post-Translational Modifications of C/EBPα ""; ""Phosphorylation of C/EBPα ""; ""Sumoylation of C/EBP. ""; ""REGULATION OF CELL CYCLE PROGRESSION BY C/EBPÎ? ""; ""Growth-Inhibiting Activity of C/EBPα ""; ""FUNCTIONAL ROLE OF C/EBPÎ? IN LINEAGE SPECIFICATION """"C/EBPα ; Function in Granulopoiesis ""; ""Cooperation of PU.1 and C/EBPα Transcription Factors in Lineage Decision ""; ""Regulation of MicroRNAs Involved in Granulocytic Differentiation by C/EBPα and Effect of MicroRNA on C/EBPα ""; ""REGULATION OF C/EBPÎ? EXPRESSION ""; ""Decreased Expression of CEBPA by Transcriptional Regulation ""; ""Decreased Expression of CEBPA by Methylation of CEBPA Gene Promoter ""; ""Decreased or Increased expression of C/EBPα by Posttranslational Regulation ""; ""ROLE OF C/EBPÎ? IN MYELOID DIFFERENTIATION AND LEUKEMIA """"CONCLUSION AND PERSPECTIVES ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES""; ""CHEMOTACTIC ASSAY OF HUMAN NEUTROPHILS AND EOSINOPHILS ""; ""INTRODUCTION ""; ""1. CHEMOTAXIS IS CRITICAL TO THE DEFENSIVE FUNCTION OF NEUTROPHILS AND EOSINOPHILS ""; ""2. MORPHOLOGICAL CHANGE OF HL-60 CELLS DURING DIFFERENTIATION ""; ""3. PHENOTYPIC CHANGE OF HL-60 CELLS DURING DIFFERENTIATION ""; ""4. FUNCTIONAL MATURATION OF HL-60 CELLS DURING DIFFERENTIATION ""; ""5. APOPTOSIS OF HL-60 CELLS DURING DIFFERENTIATION ""; ""6. CHEMOTACTIC RESPONSE OF HL-60 CELLS BY TRANSWELL ASSAY """"7. CHEMOTACTIC RESPONSE OF HL-60 CELLS OBSERVED BY VIDEO MICROSCOPY ""; ""8. EOSINOPHILS ARE MULTIFUNCTIONAL LEUKOCYTES ""; ""9. EOL-1 CELL IS A USEFUL MODEL FOR THE FUNCTIONAL STUDY OF EOSINOPHILS""; ""10. EOSINOPHILIC PRECURSOR EOL-1 CELLS EXPRESSED LYMPHOID CHEMOKINE RECEPTORS CCR7 AND CCR9 FOLLOWING CYTOKINE-INDUCED DIFFERENTIATION ""; ""11. CYTOKINE-STIMULATED DEOL-1 CELLS SHOWED DIRECTIONAL MIGRATION TO THE LYMPHOID CHEMOKINES ""; ""12. CYTOKINE-STIMULATED DEOL-1 CELLS SHOWED SURFACE EXPRESSION OF APC-RELATED COSTIMULATORY MOLECULES, AS WELL AS IDO ""