1.

Record Nr.

UNINA9910778962903321

Autore

Houwelingen J. C. van.

Titolo

Dynamic prediction in clinical survival analysis / / Hans van Houwelingen, Hein Putter

Pubbl/distr/stampa

Boca Raton : , : CRC Press, , 2012

ISBN

0-429-09433-7

1-280-12190-4

9786613525765

1-4398-3543-8

Descrizione fisica

1 online resource (250 p.)

Collana

Monographs on statistics and applied probability ; ; 123

Altri autori (Persone)

PutterHein

Disciplina

615.580724

Soggetti

Proportional hazards models

Survival analysis (Biometry)

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Note generali

"A Chapman & Hall book."

Nota di bibliografia

Includes bibliographical references.

Nota di contenuto

The special nature of survival data -- Cox regression model -- Measuring the predictive value of a Cox model -- Calibration and revision of Cox models -- Mechanisms explaining violation of the Cox model -- Non-proportional hazards models -- Dealing with non-proportional hazards -- Dynamic predictions using biomarkers -- Dynamic prediction in multi-state models -- Dynamic prediction in chronic disease -- Penalized Cox models -- Dynamic prediction based on genomic data.

Sommario/riassunto

In the last twenty years, dynamic prediction models have been extensively used to monitor patient prognosis in survival analysis. Written by one of the pioneers in the area, this book synthesizes these developments in a unified framework. It covers a range of models, including prognostic and dynamic prediction of survival using genomic data and time-dependent information. The text includes numerous examples using real data that is taken from the authors collaborative research. R programs are provided for implementing the methods--Provided by publisher.