Advances in epithelial ovarian cancer [[electronic resource] ] : model systems, microenvironmental influences, therapy, and origins / / edited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata

• Record Nr.: UNINA9910136793403321
• Autore: Ben Davidson
• Pubbl/distr/stampa: Frontiers Media SA, 2016; [Lausanne, Switzerland] : , : Frontiers Media SA, , 2016; ©2016
• Descrizione fisica: 1 online resource (176 pages) : illustrations; digital, PDF file(s)
• Collana: Frontiers Research Topics; Frontiers in oncology
• Disciplina: 616.99465
• Soggetti: Ovaries - Cancer - Research; Neoplasms; Oncology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Nota di bibliografia: a Includes bibliographical references.
• Sommario/riassunto: This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a major dilemma as models with the oncogenic aberrations common in the human malignancy do not accurately recapitulate HG-SOC. Conversely, commonly used HG-SOC cell lines have been found to not harbor the expected genetic changes. These issues as well as the rapid acceptance of patient derived xenograft ; models are reviewed. Five articles discuss different aspects of the tumor microenvironment including its role in therapy resistance, disease progression and metastasis. Mutation of BRCA1/2 continues to be the best defined risk factor for HG-SOC. Three articles discuss BRCA-loss in the context of disease development, targeted therapies and changes in preventative measures proposed for mutation carriers in light of the recent advances in knowledge regarding the origins of this malignancy. An image of HG-SOC with reduced BRCA1 expression is featured on the cover (image by VM Howell). A major clinical issue for patients with HG-SOC is the development of therapy resistance. Five articles focus on therapy resistance and different ways to overcome resistance. Overall, this eBook is an outstanding resource to aid researchers design their programs of research and determine the most appropriate and up-to-date EOC model systems to address their research questions.

Art of the gold rush [[electronic resource] /] / Janice T. Driesbach, Harvey L. Jones, and Katherine Church Holland

• Record Nr.: UNINA9910778865003321
• Autore: Driesbach Janice Tolhurst
• Pubbl/distr/stampa: Berkeley, Calif., : University of California Press, c1998
• ISBN: 1-280-49212-0; 9786613587350; 0-520-93515-2; 0-585-17648-5
• Descrizione fisica: 1 online resource (167 p.)
• Altri autori (Persone): JonesHarvey <1935->; HollandKatherine Church
• Disciplina: 759.194/07494
• Soggetti: Art, American - California - 19th century; Gold mines and mining in art; California Gold discoveries Pictorial works Exhibitions
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Catalog of an exhibition held at the Oakland Museum of California, Oakland, Calif., Jan. 24-May 31, 1998; Crocker Art Museum, Sacramento, Calif., June 20-Sept. 13, 1998; National Museum of ; American Art, Smithsonian Institution, Washington, D.C., Dec. 30, 1998- Mar. 7, 1999.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Front matter -- Contents -- Illustrations -- Foreword -- Acknowledgments -- Lenders to the Exhibition -- Introduction -- First in the Field -- Scenes of Mining Life -- Portrait Painter to the Elite -- The Hessian Party -- Souvenirs of the Mother Lode -- Mining the Picturesque -- In the Wake of the Gold Rush -- Sentiment and Nostalgia -- Biographies of the Artists -- Notes -- Selected Bibliography -- Artists Represented in the Exhibition -- Index
• Sommario/riassunto: The California Gold Rush captured the get-rich dreams of people around the world more completely than almost any event in American history. This catalog, published in celebration of the sesquicentennial of the 1848 discovery of gold at Sutter's Mill, shows the vitality of the arts in the Golden State during the latter nineteenth century and documents the dramatic impact of the Gold Rush on the American imagination. Among the throngs of gold-seekers in California were artists, many self-taught, others formally trained, and their arrival produced an outpouring of artistic works that provide insights into Gold Rush events, personages, and attitudes. The best-known painting of the Gold Rush era, C.C. Nahl's Sunday Morning in the Mines (1872), was created nearly two decades after gold fever had subsided. By then the Gold Rush's mythic qualities were well established, and new allegories-particularly the American belief in the rewards of hard work and enterprise-can be seen on Nahl's canvas. Other works added to the image of California as a destination for ambitious dreamers, an image that prevails to this day. In bringing together a range of art and archival material such as artists' diaries and contemporary newspaper articles, The Art of the Gold Rush broadens our understanding of American culture during a memorable period in the nation's history.