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Record Nr. |
UNINA9910778711903321 |
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Titolo |
Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
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Pubbl/distr/stampa |
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Washington, D.C. : , : National Academy Press, , 1988 |
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ISBN |
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1-280-22163-1 |
9786610221639 |
0-309-55513-2 |
0-585-14460-5 |
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Descrizione fisica |
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1 online resource (xi, 227 pages) : illustrations |
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Disciplina |
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Soggetti |
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Toxicity testing - Evaluation |
Toxicology, Experimental |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographies and index. |
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Nota di contenuto |
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1 Front Matter; 2 Executive Summary; 3 1. Introduction; 4 2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures; 5 3. Testing Strategies and Methods; 6 4. Sampling and Chemical Characterization; 7 5. Interpretation and Modeling of Toxicity-Test Results; 8 Appendix A: Origins of Complex Mixtures; 9 Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures; 10 Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures; 11 Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks; 12 Appendix E: Cancer Models; 13 Appendix F: Developmental Toxicology; 14 Appendix G: Empirical Modeling of the Toxicity of Mixtures; 15 Index |
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Sommario/riassunto |
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Addresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke. |
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