Toxicological effects of methylmercury [[electronic resource] /] / Committee on the Toxicological Effects of Methylmercury, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council

• Record Nr.: UNINA9910778605303321
• Pubbl/distr/stampa: Washington, DC, : National Academy Press, c2000
• ISBN: 0-309-17171-7; 1-280-18534-1; 9786610185344; 0-309-56970-2
• Descrizione fisica: 1 online resource (368 p.)
• Disciplina: 615.9/25663
• Soggetti: Methylmercury - Toxicology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: ""Toxicological Effects of Methylmercury""; ""Copyright""; ""PREFACE""; ""Contents""; ""EXECUTIVE SUMMARY""; ""THE CHARGE TO THE COMMITTEE""; ""THE COMMITTEE'S APPROACH TO ITS CHARGE""; ""THE COMMITTEE'S EVALUATION""; ""Health Effects of Methylmercury""; ""Determination of the Critical Study for the RfD""; ""Estimation of Dose and Biological Variability""; ""Modeling the Dose-Response Relationships""; ""Public Health Implications""; ""RESEARCH NEEDS""; ""RECOMMENDATIONS""; ""1 INTRODUCTION""; ""SOURCES OF HG""; ""FATE AND TRANSPORT""; ""HEALTH EFFECTS""; ""EXPOSURE EVENTS AND STUDIES""; ""SUMMARY OF RISK ASSESSMENTS FOR MEHG""""SCIENTIFIC CONTROVERSIES AND SOURCES OF UNCERTAINTY""; ""ORGANIZATION OF THE REPORT""; ""REFERENCES""; ""2 CHEMISTRY, EXPOSURE, TOXICOKINETICS, AND TOXICODYNAMICS ""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""METHODS OF CHEMICAL ANALYSIS""; ""EXPOSURES TO MEHG IN THE U.S. POPULATION""; ""TOXICOKINETICS""; ""Absorption and Distribution""; ""Methylmercury""; ""Dimethylmercury""; ""Elemental Mercury""; ""Inorganic Mercury""; ""Biotransformation""; ""Excretion""; ""MOBILIZATION OF BODY HG""; ; ""CHEMICAL FORMS OF HG IN TOXICITY""; ""TOXIC EFFECTS AND TARGET ORGANS""""BIOCHEMICAL MECHANISMS OF TOXICITY""; ""SUMMARY AND CONCLUSIONS""; ""RECOMMENDATIONS""; ""REFERENCES""; ""3 BIOLOGICAL VARIABILITY ""; ""AGE-RELATED SUSCEPTIBILITY""; ""GENDER DIFFERENCES""; ""GENETICS""; ""MECHANISMS OF NUTRITIONAL INFLUENCE ON MEHG HEALTH EFFECTS""; ""Dietary Interactions and Confounding""; ""Selenium""; ""Garlic""; ""Omega-3 Fatty Acids""; ""Protein""; ""Alcohol""; ""Other Foods That Might Influence Hg Uptake""; ""Vitamin E""; ""Nutrient Enhancement of Toxicity""; ""Beneficial Effects of Fish Consumption""; ""TOXICOKINETIC VARIABILITY""; ""CONCLUSIONS""""RECOMMENDATIONS""; ""REFERENCES""; ""4 DOSE ESTIMATION ""; ""DIETARY ASSESSMENT""; ""BIOMARKERS OF EXPOSURE""; ""Methylmercury in Blood""; ""Methylmercury in Hair""; ""Comparison of Biomarkers of Exposure""; ""ANALYTICAL ERROR IN BIOMARKER MEASUREMENTS""; ""EXPOSURE AND DOSE ASSESSMENT IN THE SEYCHELLES, FAROE ISLANDS, AND NEW ZEALAND STUDIES""; ""SUMMARY AND CONCLUSIONS""; ""RECOMMENDATIONS""; ""REFERENCES""; ""5 HEALTH EFFECTS OF METHYLMERCURY ""; ""CARCINOGENICITY""; ""Human Studies""; ""Animal Studies""; ""GENOTOXICITY""; ""Human Studies""; ""Animal Studies""; ""In Vitro Studies""""IMMUNOTOXICITY""; ""Human Studies""; ""Animal Studies""; ""Effects on the Adult Immune System""; ""Effects on the Developing Immune System""; ""In Vitro Studies""; ""Autoimmune Response""; ""Human Studies""; ""Animal Studies""; ""REPRODUCTIVE EFFECTS""; ""Human Studies""; ""Animal Studies""; ""RENAL TOXICITY""; ""Human Studies""; ""Animal Studies""; ""CARDIOVASCULAR EFFECTS""; ""Human Studies""; ""Animal Studies""; ""HEMATOLOGICAL EFFECTS""; ""DEVELOPING CENTRAL-NERVOUS-SYSTEM TOXICITY""; ""Human Studies""; ""High-Dose Poisonings""; ""Poisoning Episode in Japan""; ""Poisoning Episode in Iraq""