| |
|
|
|
|
|
|
|
|
1. |
Record Nr. |
UNINA9910788570503321 |
|
|
Autore |
Smith Kendall A |
|
|
Titolo |
The quantal theory of immunity [[electronic resource] ] : the molecular basis of autoimmunity and leukemia / / Kendall A. Smith |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Singapore ; ; Hackensack, N.J., : World Scientific, 2010 |
|
|
|
|
|
|
|
ISBN |
|
1-283-14368-2 |
9786613143686 |
981-4271-76-4 |
|
|
|
|
|
|
|
|
Descrizione fisica |
|
1 online resource (200 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
|
|
Soggetti |
|
Immune response |
Interleukin-2 |
T cells |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Description based upon print version of record. |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references and index. |
|
|
|
|
|
|
Nota di contenuto |
|
Acknowledgements; Prologue; Contents; Chapter 1 Introduction - The Evolution of Our Understanding of the Immune System; Chapter 2 Molecular Immunology; Chapter 3 The Problem - Understanding How Molecules Direct the Behavior of Cells Comprising the Immune System; Chapter 4 The Quantal Theory of Immunity; Chapter 5 The Variability of Cell Cycle Progression and the Competence and Progression Phases of the Cell Cycle; Chapter 6 The Quantal Nature of IL-2-Promoted T Cell Cycle Progression |
Chapter 7 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - TheIL-2/Receptor InteractionChapter 8 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell CycleProgression - IL-2 and IL-2 Receptor Metabolism; Chapter 9 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - IL-2 Receptor Signaling viathe Jak/Stat Pathway; Chapter 10 The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression - IL-2 Receptor Signaling via Phospho |
Chapter 11 The T Cell Antigen Receptor Complex and the Quantal |
|
|
|
|
|
|
|
|
|
|
|
Regulation of the IL-2 and IL-2R GenesChapter 12 Digital Signaling via the T Cell Antigen Receptor Complex; Chapter 13 Negative Feedback Regulation of T Cell Antigen Receptor Complex Signaling - Attenuation of IL-2Gene Expression; Chapter 14 The Paradox of the IL-2 (-/-) Mouse; Chapter 15 The Scurfy Mouse; Chapter 16 Lymphopenia, Autoimmunity and the Regulatory T Cell (Treg); Chapter 17 Treg-mediated "Active Suppression" of T Cell Proliferation; Chapter 18 FOXP3, A Better ID-Tag for Tregs?; Chapter 19 Mice Versus Men |
Chapter 20 Active Versus Passive Suppression and IL-2 MetabolismChapter 21 FOXP3 Restricts But Does Not Suppress IL-2 Production; Chapter 22 Both the TCR and IL-2 Regulate FOXP3 Expression; Chapter 23 The Effects of FOXP3 Expression; Chapter 24 The Role of IL-2 in the Generation of Immune Responses In Vivo; Chapter 25 The Role of the IL-2r Chains in IL-2 Signaling, Consumption and Suppression of T Cell Proliferation; Chapter 26 T Cell Tissue-specific Autoimmunity; Chapter 27 Type 1 Diabetes Mellitus (T1DM), a Prototypic Genetic Autoimmune Disease with a Tie to IL-2 |
Chapter 28 The Pathogenesis of Leukemia - Loss of Normal Quantal Growth ControlEpilogue; Index |
|
|
|
|
|
|
Sommario/riassunto |
|
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2. |
Record Nr. |
UNINA9910777676703321 |
|
|
Autore |
Anderson Betty S (Betty Signe), <1965-> |
|
|
Titolo |
Nationalist voices in Jordan [[electronic resource] ] : the street and the state / / Betty S. Anderson |
|
|
|
|
|
|
|
Pubbl/distr/stampa |
|
|
Austin, TX, : University of Texas Press, 2005 |
|
|
|
|
|
|
|
ISBN |
|
|
|
|
|
|
Edizione |
[1st ed.] |
|
|
|
|
|
Descrizione fisica |
|
1 online resource (301 p.) |
|
|
|
|
|
|
Disciplina |
|
|
|
|
|
|
Soggetti |
|
National characteristics, Jordanian |
Arab nationalism - Jordan |
Opposition (Political science) - Jordan |
Jordan Politics and government 20th century |
|
|
|
|
|
|
|
|
Lingua di pubblicazione |
|
|
|
|
|
|
Formato |
Materiale a stampa |
|
|
|
|
|
Livello bibliografico |
Monografia |
|
|
|
|
|
Note generali |
|
Bibliographic Level Mode of Issuance: Monograph |
|
|
|
|
|
|
Nota di bibliografia |
|
Includes bibliographical references (p. 245-269) and index. |
|
|
|
|
|
|
Nota di contenuto |
|
The writing of a national narrative -- The "domains" of national identity -- Conceiving Transjordan, 1921-1948 -- Hashemites and Jordanians, 1921-1948 -- Hashemites and Palestinians, 1921-1948 -- Forging the Jordanian national movement (JNM) -- Opposition and cooperation : the state and the Jordanian national movement (JNM), 1952-1956 -- Success and failure : the Jordanian national movement (JNM), 1956-1957 -- The Hashemites ascendant. |
|
|
|
|
|
|
|
|
Sommario/riassunto |
|
According to conventional wisdom, the national identity of the Jordanian state was defined by the ruling Hashemite family, which has governed the country since the 1920s. But this view overlooks the significant role that the "Arab street"—in this case, ordinary Jordanians and Palestinians—played and continues to play in defining national identity in Jordan and the Fertile Crescent as a whole. Indeed, as this pathfinding study makes clear, "the street" no less than the state has been a major actor in the process of nation building in the Middle East during and after the colonial era. In this book, Betty Anderson examines the activities of the Jordanian National Movement (JNM), a collection of leftist political parties that worked to promote pan-Arab unity and oppose the continuation of a separate Jordanian state from the 1920s through the 1950s. Using primary sources including |
|
|
|
|
|
|
|
|
|
|
memoirs, interviews, poetry, textbooks, and newspapers, as well as archival records, she shows how the expansion of education, new jobs in the public and private sectors, changes in economic relationships, the establishment of national militaries, and the explosion of media outlets all converged to offer ordinary Jordanians and Palestinians (who were under the Jordanian government at the time) an alternative sense of national identity. Anderson convincingly demonstrates that key elements of the JNM's pan-Arab vision and goals influenced and were ultimately adopted by the Hashemite elite, even though the movement itself was politically defeated in 1957. |
|
|
|
|
|
| |