Spacecraft maximum allowable concentrations for selected airborne contaminants . Volume 1 [[electronic resource] /] / Subcommittee on Spacecraft Maximum Allowable Concentrations, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council

• Record Nr.: UNINA9910777584203321
• Pubbl/distr/stampa: Washington, D.C., : National Academy Press, 1994
• Descrizione fisica: 1 online resource (235 p.)
• Disciplina: 629.477
• Soggetti: Space cabin atmospheres; Space vehicles - Air pollution; Space vehicles - Air quality - Standards; Space vehicles - Contamination; Space vehicles - Environmental aspects; Toxicology - Research - United States
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: "The project was supported by the National Aeronautics and Space Administration grant no. NAGW-2239."
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: ""Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants""; ""Copyright""; ""Preface""; ""Contents""; ""Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants""; ""INTRODUCTION""; ""SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING SMACS""; ""REVIEW OF SMAC REPORTS""; ""REFERENCES""; ""Appendix A Executive Summary of Guidelines for Developing Spacecraft Maximum Allowable Concentration for Space Stationâ€?""; ""EXECUTIVE SUMMARY: SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SPACE STATION CONTAMINANTS""; ""ENVIRONMENTAL CONTROL AND LIFE-SUPPORT SYSTEM""""MODIFICATION OF CONTAMINANT TOXICITY BY ENVIRONMENTAL FACTORS""; ""SOURCES AND TYPES OF DATA FOR ESTABLISHMENT OF SMACS""; ""Chemical-Physical Characteristics of Toxicants""; ""In Vitro Toxicity Studies""; ""Animal Toxicity Studies""; ""Clinical and ; Epidemiological Observations""; ""Pharmacokinetics and Metabolism""; ""Biological Markers""; ""RISK ASSESSMENT (DEVELOPMENT OF EXPOSURE CRITERIA)""; ""ISSUES IN MAKING RECOMMENDATIONS FOR THE ESTABLISHMENT OF SMACS""; ""Appendix B Reports on Spacecraft Maximum Allowable Concentrations (SMACs) for Selected Airborne Contaminants""""B1 ACETALDEHYDE""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS AND METABOLISM""; ""TOXICITY SUMMARY""; ""Acute Toxicity""; ""Mucosal Irritation""; ""Miscellaneous Mucosal Effects""; ""Lethality""; ""Subchronic and Chronic Toxicity""; ""Nasal Toxicity""; ""Pulmonary and Renal Toxicity""; ""Carcinogenicity""; ""Genotoxicity""; ""Reproductive and Developmental Toxicity""; ""Synergistic Effects""; ""RATIONALE""; ""Carcinogenicity""; ""Mucosal Irritation""""The Establishment of SMACs""; ""REFERENCES""; ""B2 AMMONIA""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS AND METABOLISM""; ""TOXICITY SUMMARY""; ""Mechanisms of Tissue Injuries""; ""Mucosal Irritation in Naive Subjects""; ""Mucosal Irritation in Adapted Subjects""; ""Mucosal Irritation in Subjects Of Unknown Adaptation Status""; ""Toxic Effects of Massive Exposures""; ""Animal Models of Ammonia's Respiratory Damage""; ""Metabolic Acidosis""; ""RATIONALE""; ""1-h SMAC and 24-h SMAC""; ""7-d SMAC""; ""30-d SMAC and 180-d SMAC""; ""REFERENCES""""B3 CARBON MONOXIDE""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS""; ""TOXICITY SUMMARY""; ""Acute Toxicity""; ""Adaptation""; ""Subchronic and Chronic Toxicity""; ""Synergistic Effects""; ""RATIONALE""; ""1-h SMAC""; ""24-h SMAC""; ""7-d SMAC""; ""30-d SMAC and 180-d SMAC""; ""1-h and 24-h SMACs Immediately Following CO Exposure""; ""REFERENCES""; ""B4 FORMALDEHYDE""; ""PHYSICAL AND CHEMICAL PROPERTIES""; ""OCCURRENCE AND USE""; ""PHARMACOKINETICS AND METABOLISM""; ""TOXICITY SUMMARY""; ""Acute Toxicity""; ""Subchronic and Chronic Toxicity""