Protein degradation . Vol. 4 The ubiquitin-proteasome system and disease / / edited by R. John Mayer, Aaron Ciechanover, Martin Rechsteiner

• Record Nr.: UNINA9910144007703321
• Pubbl/distr/stampa: Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008; ©2008
• ISBN: 1-283-14037-3; 9786613140371; 3-527-62023-0; 3-527-62030-3
• Descrizione fisica: 1 online resource (260 p.)
• Collana: Protein Degradation ; ; v.8
• Disciplina: 572.76; 612.3/98
• Soggetti: Proteins - Metabolism; Ubiquitin; Electronic books.
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Protein Degradation; Contents; Preface; List of Contributors; 1 Ubiquitin Signaling and Cancer Pathogenesis; 1.1 Introduction; 1.1.1 Ubiquitin Signaling Networks; 1.1.2 Ubiquitin-like Proteins; 1.2 Ubiquitin in Cancer Pathogenesis; 1.2.1 Ubiquitin in Cell Cycle Control; 1.2.2 Ubiquitin in the NF-κB Pathway; 1.2.3 Ubiquitin as a Signal in DNA Repair; 1.2.3.1 p53 Pathway; 1.2.3.2 BRCA1 and FANCD2; 1.2.3.3 PCNA and TLS Polymerases; 1.2.4 Ubiquitin Networks in Angiogenesis; 1.2.5 Ubiquitin Networks in Receptor Endocytosis; 1.3 Targeting Ubiquitin Networks in Cancers; 1.3.1 Targeting Interactions between E3s and their Substrates1.3.2 Targeting the Proteasome; 1.3.3 Other Approaches; 1.4 Conclusions and Future Perspectives; 2 Regulation of the p53 Tumor-suppressor Protein by Ubiquitin and Ubiquitin-like Molecules; 2.1 Functional Domains of p53; 2.2 The Family of Ubiquitin-like Molecules; 2.3 E3 ; Ligases for p53; 2.4 Modification of p53 with Ubiquitin; 2.5 Requirements for Mdm2-mediated Ubiquitination of p53; 2.6 Regulation of p53 Ubiquitination; 2.6.1 E2 Conjugating Enzymes; 2.6.2 Interacting Proteins; 2.6.3 By Other Post-translational Modifications; 2.7 De-ubiquitination of p532.8 SUMO-1/sentrin/smpt3; 2.9 NEDD8/Rub1; 2.10 Therapeutic Intervention through the Ubiquitin Pathway; 3 The Ubiquitin-Proteasome System in Epstein-Barr Virus Infection and Oncogenesis; 3.1 Introduction; 3.2 Viral Interference with the Ubiquitin-Proteasome System; 3.3 The EBV Life Cycle; 3.4 EBV and the Ubiquitin-Proteasome System; 3.4.1 EBNA1; 3.4.2 EBNA6 (EBNA3C); 3.4.3 LMP1; 3.4.4 LMP2; 3.4.5 BZLF1 (Zta) and BRLF1 (Rta); 3.4.6 BPLF1; 3.5 EBV-associated Malignancies; 3.6 Concluding Remarks; 4 HECT Ubiquitin-protein Ligases in Human Disease; 4.1 Introduction; 4.2 Definition of HECT E3s4.3 Human HECT E3s and their Role in Disease; 4.4 E6-AP; 4.4.1 E6-AP and Cervical Cancer (Cancer of the Uterine Cervix); 4.4.2 E6-AP and Angelman Syndrome; 4.5 HECTH9; 4.6 HECT E3s with WW Domains; 4.6.1 Nedd4/Nedd4-2; 4.6.1.1 Nedd4/Nedd4-2 and Liddle's Syndrome; 4.6.1.2 Nedd4 and Retrovirus Budding; 4.6.2 Itch and the Immune Response; 4.6.3 Smurfs; 4.6.3.1 Smurfs and Cancer; 4.6.3.2 Smurfs and Bone Homeostasis; 4.7 Concluding Remarks; 5 Ubiquitin-independent Mechanisms of Substrate Recognition and Degradation by the Proteasome; 5.1 Introduction; 5.2 Ubiquitin-independent Proteasome Substrates5.2.1 Ornithine Decarboxylase; 5.2.2 p21(Waf1/Cip1); 5.2.3 Retinoblastoma Protein; 5.2.4 p53 and p73; 5.2.5 Human Thymidylate Synthase; 5.2.6 Rpn4; 5.2.7 NF-κB and IκBα; 5.2.8 Steroid Receptor Co-activator-3; 5.2.9 c-Jun; 5.3 Mechanisms of Ubiquitin-independent Degradation; 5.4 Conclusion; 6 Endoplasmic Reticulum Protein Quality Control and Degradation; 6.1 Introduction; 6.2 ER-import, Folding and the Unfolded Protein Response; 6.3 General Principles and Components of ERQD (Endoplasmic Reticulum Quality Control and Protein Degradation); 6.4 Mechanism of ERQD
• Sommario/riassunto: This final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research.From the contents:* Ubiquitin and cancer * Ubiquitin and liver cancer* Muscle atrophy* Aggresomes and human disease* Parkin and neurodegeneration* Chronic neurodegenerative diseases* Parkinson's disease* Ubiquitin and viruses* Druggability of the ubiquitin-proteas

A history of Russian Christianity . Volume III The Synodal era and the Sectarians 1725 to 1894 [[electronic resource] /] / Daniel H. Shubin

• Record Nr.: UNINA9910777547303321
• Autore: Shubin Daniel H
• Pubbl/distr/stampa: New York, : Algora Pub., 2005
• ISBN: 1-281-39559-5; 9786611395599; 0-87586-427-9; 0-87586-426-0
• Descrizione fisica: 1 online resource (234 p.)
• Disciplina: 274.7
• Soggetti: Russia (Federation) Church history
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: pt. 7. The eighteenth century -- pt. 8. The nineteenth century.
• Sommario/riassunto: From the legendary visit of Apostle Andrew to the conclusion of Soviet authority in 1990, Daniel Shubin presents the entire history of Christianity in Russia in a multi-volume series. The events, people and politics that forged the earliest traditions of

Quo Vadis: Evolution of Modern Navigation : The Rise of Quantum Techniques / / by F. G. Major

• Record Nr.: UNINA9910298375503321
• Autore: Major F. G
• Pubbl/distr/stampa: New York, NY : , : Springer New York : , : Imprint : Springer, , 2014
• ISBN: 1-4614-8672-6
• Edizione: [1st ed. 2014.]
• Descrizione fisica: 1 online resource (428 p.)
• Disciplina: 629.1; 910; 910.285; 910285
• Soggetti: Geographic information systems; Remote sensing; Aerospace engineering; Astronautics; Geographical Information Systems/Cartography; Remote Sensing/Photogrammetry; Aerospace Technology and Astronautics
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: 1. Navigation in Nature -- 2. The Early Navigators -- 3. Historical Background to Astronomy -- 4. Modern Astronomy -- 5. Navigation at Sea -- 6. The Longitude Problem -- 7. The Quartz Revolution -- 8. Classical Atomic Frequency Standards -- 9. Atomic and Molecular Oscillators -- 10. Field Confinement of Ions -- 11. Optical Frequency Oscillators: Lasers -- 12. The Gyrocompass -- 13. Radio Navigation -- 14. Satellite Navigation: GPS Space Segment -- 15. Satellite Navigation: GPS Control Segment -- 16. Satellite Navigation: GPS User Segment -- 17. Space Navigation -- 18. The Future of Navigation.
• Sommario/riassunto: Quo Vadis: Evolution of Modern Navigation presents an intelligent and intelligible account of the essential principles underlying the design of satellite navigational systems—with introductory chapters placing them in context with the early development of navigational methods. The ; material is organized roughly as follows: the first third of the book deals with navigation in the natural world, the early history of navigation, navigating by the stars, precise mechanical chronometers for the determination of longitude at sea, and the development of precise quartz controlled clocks. Then, the reader is introduced to quantum ideas as a lead in to a discussion of microwave and optical interactions with atoms, atomic clocks, laser gyrocompasses, and time based navigation. The final third of the book deals with satellite-based systems, including orbit theory, early satellite navigation systems, and a detailed treatment of the Global Positioning System (GPS). Intended for non-specialists with some knowledge of physics or engineering at the college level, this book covers in an intuitive manner a broad range of topics relevant to the evolution of surface and space navigation, with minimum mathematical formalism.