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1. |
Record Nr. |
UNINA9910132261703321 |
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Titolo |
Antitargets and drug safety / / edited by Lásló Urbán, Vinod F. Patel, and Roy J. Vaz |
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Pubbl/distr/stampa |
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Weinheim, Germany : , : Wiley-VCH, , [2015] |
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©2015 |
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ISBN |
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3-527-67364-4 |
3-527-67366-0 |
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Descrizione fisica |
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1 online resource (1266 p.) |
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Collana |
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Methods and principles in medicinal chemistry ; ; volume 66 |
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Disciplina |
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Soggetti |
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Drugs - Side effects |
Drugs - Side effects - Prevention |
Drug interactions |
Drug development |
Drugs - Structure-activity relationships |
Drug-Related Side Effects and Adverse Reactions |
Protein Kinase Inhibitors - adverse effects |
Pharmacovigilance |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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section 1. General concept for target-based safety assessment -- section 2. Hepatic side effects -- section 3. Cardiovascular side effects -- section 4. Kinase antitargets -- section 5. Examples of clinical translation. |
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Sommario/riassunto |
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With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing |
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2. |
Record Nr. |
UNINA9910772089103321 |
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Autore |
Freeman Elizabeth <1966-> |
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Titolo |
Beside you in time : sense methods and queer sociabilities in the American 19th century / / Elizabeth Freeman |
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Pubbl/distr/stampa |
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Durham, NC, : Duke University Press, 2019 |
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Durham : , : Duke University Press, , 2019 |
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©2019 |
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ISBN |
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Descrizione fisica |
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1 online resource (xii, 228 pages) |
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Disciplina |
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Soggetti |
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Time - Social aspects - United States - History - 19th century |
Homosexuality - Social aspects - United States - History - 19th century |
Time perception in literature |
Human body in literature |
American literature - African American authors - 19th century - History and criticism |
Literature and society - United States - History - 19th century |
Queer theory |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Shake it off : the physiopolitics of Shaker dance, 1774-1856 -- The gift of constant escape : playing dead in African American literature, 1849-1900 -- Feeling historicisms : libidinal history in Twain and Hopkins -- The sense of unending : defective chronicity in "Bartleby, the scrivener" and "Melanctha" -- Sacra/mentality in Djuna Barnes's Nightwood. |
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Sommario/riassunto |
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In Beside You in Time Elizabeth Freeman expands biopolitical and queer theory by outlining a temporal view of the long nineteenth century. Drawing on Foucauldian notions of discipline as a regime that yoked the human body to time, Freeman shows how time became a social and sensory means by which people assembled into groups in ways that resisted disciplinary forces. She tracks temporalized bodies across many entangled regimes—religion, secularity, race, historiography, health, and sexuality—and examines how those bodies act in relation to those regimes. In analyses of the use of rhythmic |
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dance by the Shakers; African American slave narratives; literature by Mark Twain, Pauline Hopkins, Herman Melville, and others; and how Catholic sacraments conjoined people across historical boundaries, Freeman makes the case for the body as an instrument of what she calls queer hypersociality. As a mode of being in which bodies are connected to others and their histories across and throughout time, queer hypersociality, Freeman contends, provides the means for subjugated bodies to escape disciplinary regimes of time and to create new social worlds. |
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