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Record Nr. |
UNINA9910765760803321 |
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Titolo |
Advances in Micro-Bioreactor Design for Organ Cell Studies / / edited by Carl-Fredrik Mandenius |
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Pubbl/distr/stampa |
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Basel : , : MDPI, , 2018 |
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©2018 |
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ISBN |
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Descrizione fisica |
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1 online resource (vii, 157 pages) : illustrations |
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Collana |
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Disciplina |
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Soggetti |
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Bioengineering |
Bioreactors |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di bibliografia |
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Includes bibliographical references. |
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Nota di contenuto |
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Carl-Fredrik Mandenius -- Clare Selden and Barry Fuller -- Claudia Kuhlbach, Sabrina da Luz, Frank Baganz, Volker C. Hass and Margareta M. Mueller -- Yi-Chin Toh, Anju Raja, Hanry Yu and Danny van Noort -- Ana C. Fernandes, Julia M. Halder, Bettina M. Nestl, Bernhard Hauer, Krist V. Gernaey and Ulrich Kruhne -- Krzysztof Wrzesinski and Stephen J. Fey -- Nora Freyer, Selina Greuel, Fanny Knospel, Florian Gerstmann, Lisa Storch, Georg Damm, Daniel Seehofer, Jennifer Foster Harris, Rashi Iyer, Frank Schubert and Katrin Zeilinger -- Jonas Christoffersson, Florian Meier, Henning Kempf, Kristin Schwanke, Michelle Coffee, Mario Beilmann, Robert Zweigerdt and Carl-Fredrik Mandenius -- Tannaz Tajsoleiman, Mohammad Jafar Abdekhodaie, Krist V. Gernaey and Ulrich Kruhne. |
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Sommario/riassunto |
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Micro-bioreactors offer unique opportunities to study biological systems under fluidic conditions. The concept of micro-bioreactors suggests that biological reaction conditions at a large scale can be scaled down to micro-volumes while maintaining performance and functionality. Models and operation principles can be simulated at a smaller scale, either by scaling down organs in the human body, or bioreactors for the production of biologics. This book highlights these issues with much focus on new engineering design approached. Initial chapters cover conceptual design of microbioreactors and organ-on-chips, and the role of microbioreactors in tissue engineering for the |
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clinical and for therapeutic targets. Two chapters are dedicated to microbioreactors for implementing tumour models. Other chapters discuss three-dimensional models for hepatic and cardiac cells for toxicity testing and drug evaluation. Finally, the design of organ chips for cartilage scaffolds and integration of sensors are covered in separate chapters. We believe the book have substantial value for researchers active in bioreactor engineering, drug development and cell physiology as well as readers interested in the these topics. |
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2. |
Record Nr. |
UNINA9910785669203321 |
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Titolo |
Digital games and learning [[electronic resource] /] / edited by Sara de Freitas and Paul Maharg |
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Pubbl/distr/stampa |
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New York, : Continuum, 2010 |
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ISBN |
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1-282-97767-9 |
9786612977671 |
1-4411-7719-1 |
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Descrizione fisica |
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1 online resource (309 p.) |
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Altri autori (Persone) |
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FreitasSara de |
MahargPaul |
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Disciplina |
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Soggetti |
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Education - Computer-assisted instruction |
Video games |
Educational games |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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pt. 1. Theoria : theoretical positions -- pt. 2. Cultura : cultural perspectives -- pt. 3. Praxis : theory into practice. |
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Sommario/riassunto |
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The popularity of entertainment gaming over the last decades has led to the use of games for non-entertainment purposes in areas such as training and business support. The emergence of the serious games movement has capitalized on this interest in leisure gaming, with an increase in leisure game approaches in schools, colleges, universities and in professional training and continuing professional development. |
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The movement raises many significant issues and challenges for us. How can gaming and simulation technologies be used to engage learners? How can games be used to motivate, deepen and acc |
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3. |
Record Nr. |
UNINA9910824559203321 |
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Autore |
Stein Wilfred D. |
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Titolo |
Channels, carriers, and pumps : an introduction to membrane transport / / Wilfred D. Stein, Thomas Litman |
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Pubbl/distr/stampa |
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London, England : , : Academic Press, , 2015 |
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©2015 |
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ISBN |
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0-12-416583-4 |
0-12-416579-6 |
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Edizione |
[Second edition.] |
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Descrizione fisica |
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1 online resource (423 p.) |
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Disciplina |
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Soggetti |
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Biological transport - Regulation |
Biological transport, Active |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di contenuto |
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Front Cover; Channels, Carriers, and Pumps; Copyright Page; Dedications; Contents; Preface to the First Edition; Preface to the Second Edition; List of Symbols; 1 Structural Basis of Movement Across Cell Membranes; 1.1 Membrane Structure: Electron Microscopy of Biological Membranes; 1.2 Chemical Composition of Biological Membranes; 1.2.1 Membrane Lipids; 1.2.2 Membrane Proteins; 1.2.3 Membrane Carbohydrates; 1.3 Membrane Phospholipid Structures and Their Self-Assembly; 1.4 Phase Transitions in Biological Membranes; 1.5 Membrane Proteins: Their Structure and Arrangement |
1.5.1 Proteins That Span the Membrane Only Once1.5.2 Proteins That Span the Membrane More Than Once; 1.6 Synthesis of Membrane Proteins; 1.7 Quantitation of Membrane Dynamics; 1.8 Traffic Across the Plasma Membrane; 1.9 The Cell Membrane as a Barrier and as a Passage; Suggested Readings; General; Membrane Structure; Membrane Lipids; Liposomes; Membrane Proteins; Membrane Dynamics; Glycophorin; Lactose Permease; Hydropathy Plots; Membrane Protein |
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Structure; Synthesis of Membrane Proteins; Endocytosis, Membrane Turnover; Clathrin-Coated Pits and Caveolae; Lipid Rafts; Cytoskeleton |
2 Simple Diffusion of Nonelectrolytes and Ions2.1 Diffusion as a Random Walk; 2.2 The Electrical Force Acting on an Ion; 2.3 Permeability Coefficients and Partition Coefficients; 2.4 Measurement of Permeability Coefficients; 2.5 Analysis of Permeability Data; 2.6 The Membrane as a Hydrophobic Sieve; 2.7 Osmosis and the Diffusion of Water; 2.8 Comparison of Osmotic and Diffusive Flow of Water; Suggested Readings; General; Diffusion as a Random Walk; Chemical Potential; Electrical Potential; Flux Ratio Test; Permeability and Partition Coefficients; Measurement of Permeability Coefficients |
NMR and ESRUnstirred Layers; Plant Cell Permeabilities; Membrane as a Hydrophobic Sieve; Osmosis and the Diffusion of Water; Water Channels - The Aquaporins; Electroosmosis and Streaming Potential; 3 Ion Channels Across Cell Membranes; 3.1 The Gramicidin Channel; 3.2 The Acetylcholine Receptor Channel; 3.3 Conductances and Cross-Sectional Areas of Single Channels; 3.4 An Experimental Interlude; 3.4.1 Identification of Channels by Patch-Clamping; 3.4.2 Measurements of Membrane Potential by Using Intracellular Microelectrodes or by Following Dye Distribution |
3.5 Diffusion Potentials: Goldman-Hodgkin-Katz Equation3.6 Regulation and Modulation of Channel Opening; 3.6.1 The Potassium Channel of Sarcoplasmic Reticulum; 3.6.2 Sodium and Potassium Channels of Excitable Tissue; 3.6.3 The Cell-to-Cell Channel or Gap Junction; 3.6.4 Regulation and Modulation of Some Other Channels; Suggested Readings; Internet Resources; General; Electrostatic (Born) Free Energy; Gramicidin Channel; Enzyme Kinetics; Acetylcholine Receptor; Cloning and Molecular Biology; Acetylcholine Receptor Structure; Ionic Diffusion; Ligand-gated Ion Channels |
Charge Effects on Channel Conductance |
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Sommario/riassunto |
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An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in |
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