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1. |
Record Nr. |
UNINA990004480640403321 |
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Autore |
Landau-Aldanov, Mark Aleksandrovich <1886-1957> |
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Titolo |
Lénine / M.-A. Landau-Aldanov |
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Pubbl/distr/stampa |
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Edizione |
[4e ed.] |
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Descrizione fisica |
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Collana |
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Bibliothèque d'histoire contemporaine |
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Locazione |
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Collocazione |
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4/VIII A 29 |
XXI C 385 |
XIV F 21 |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNINA9910348228303321 |
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Autore |
Fergus Edward <1974-> |
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Titolo |
Skin color and identity formation : perceptions of opportunity and academic orientation among Mexican and Puerto Rican youth / / Edward Fergus |
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Pubbl/distr/stampa |
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New York, : Routledge, 2004 |
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ISBN |
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9781135931292 |
1135931291 |
9781135931308 |
1135931305 |
9781280168321 |
1280168323 |
9780203338247 |
0203338243 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (206 p.) |
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Collana |
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Classificazione |
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SOC000000SOC008000SOC026000 |
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Disciplina |
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Soggetti |
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Mexican Americans - Education (Secondary) - Michigan - Detroit |
Puerto Ricans - Education (Secondary) - Michigan - Detroit |
Mexican American youth - Race identity - Michigan - Detroit |
Puerto Rican youth - Race identity - Michigan - Detroit |
Mexican American youth - Michigan - Detroit - Attitudes |
Puerto Rican youth - Michigan - Detroit - Attitudes |
Urban high schools - Michigan - Detroit |
Human skin color - Social aspects - United States |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Mapping explanations of academic variability and racial/ethnic identification -- Methods -- Portraits of self-identification -- Negotiating identification with other students and teachers -- Perceptions of life chances -- Conceptualizing and navigating the school space -- Toward an understanding of the educational implications of skin color variation. |
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Sommario/riassunto |
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The focus of this study is on the ways in which skin color moderates the perceptions of opportunity and academic orientation of 17 Mexican and Puerto Rican high school students. More specifically, the study's analysis centered on cataloguing the racial/ethnic identification shifts (or not) in relation to how they perceive others situate them based on skin color. |
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3. |
Record Nr. |
UNINA9910751390203321 |
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Autore |
Zhang Jiapu |
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Titolo |
Optimization-based Molecular Dynamics Studies of SARS-CoV-2 Molecular Structures : Research on COVID- 19 / / by Jiapu Zhang |
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Pubbl/distr/stampa |
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Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2023 |
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ISBN |
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9783031367731 |
9783031367724 |
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Edizione |
[1st ed. 2023.] |
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Descrizione fisica |
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1 online resource (956 pages) |
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Collana |
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Springer Series in Biophysics, , 1868-2561 ; ; 23 |
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Disciplina |
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Soggetti |
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Biomolecules |
Physical biochemistry |
Macromolecules |
Molecular biology |
Biophysics |
Proteins |
Bioinformatics |
Structural Biology |
Molecular Biology |
Molecular Biophysics |
Protein Biochemistry |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1 Papain-Like cysteine protease (PLpro) -- 2 3C-Like protease (3CLpro) -- 3 RNA-dependent RNA polymerase (RdRp) -- 4 RNA-helicase -- 5 |
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RNA-helicase binding with [RdRp, NSP7, NSP8a, NSP8b, pRNA, tRNA, ADP-Mg2+, ATP-Mg2+] -- 6 RNA-helicase binding with [ADP-Mg2+, ATP-Mg2+, and RNA] -- 7 Spike (S) glycoprotein -- 8 Spike (S) glycoprotein D614G mutant -- 9 Spike (S) glycoprotein N501Y mutant -- 10 Spike (S) glycoprotein N165A-and-N234A mutant -- 11 SARS (SARS-CoV-1) -- 12 MERS-coronavirus (MERS) -- 13 Human-ACE2, human-L6, human-L6R, human-nAChRs -- 14 PLpro binding with 12 compounds -- 15 3CLpro binding with N3/Lopinavir/Ritonavir -- 16 3CLpro dimer binding with 7 HIV-inhibitors and Others -- 17 Spike RBDs binding with 50 drugs -- 18 Human ACE2 ectodomain binding with 78 drugs -- 19 Spike-and-ACE2 binding with 100 drugs -- 20 Envelope protein (E-protein) -- 21 Membrane glycoprotein (M-protein) -- 22 Nucleocapsid phosphoprotein (N-protein) -- 23 SARS-CoV-2 RNA genome -- 24 NSP7, NSP8, NSP9, NSP10, NSP16, NSP14 -- 25 NSP15 -- 26 Other mutants -- 27 Vaccines and Drugs -- 28 Pandemic Mathematical Models, Epidemiology and Virus Origins -- A Mathematical Optimization Algorithms and Free Energy Calculations -- References -- Index. |
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Sommario/riassunto |
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COVID-19 has brought us extensive research databases in the fields of biophysics, biology, and bioinformatics. To extract valuable structural bioinformatic information of SARS-CoV-2 structural and nonstructural proteins, it is necessary to work with large-scale datasets of molecular dynamics (MD) trajectories that need to be optimized. This monograph serves as a comprehensive guide to optimization-based MD studies of the molecular structures of SARS-CoV-2 proteins and RNA. The book begins by performing local optimization, taking into account the three-body movement and optimizing the noncovalent bonds of each molecular structure. The optimized structures reach a transition state that offers the best stability and lowest energy. The optimization process utilizes a hybrid strategy that combines mathematical optimization with various local search algorithms. This approach significantly reduces data volume while eliminating irrelevant bioinformatics data. To gain a thorough understanding of molecular stability and the mechanism of action, it is essential to consider not only static NMR, X-ray, or cryo-EM structures but also dynamic information obtained through MD or Quantum Mechanics/Molecular Mechanics (QM/MM) simulations. These simulations capture the internal motions and dynamic processes of molecules. Furthermore, for each protein, the structural bioinformatics obtained from the optimized structure is validated by analyzing large-scale MD trajectory databases, which are openly and freely available online. The analysis includes key structural bioinformatics aspects such as salt bridge electrostatic interactions, hydrogen bonds, van der Waals interactions, and hydrophobic interactions specific to each SARS-CoV-2 molecular structure. The book also delves into discussions on drugs, vaccines, and the origins of the virus. Additionally, pandemic mathematical models, including those incorporating time delays, areexplored. This book is particularly valuable for professionals working in practical computing roles within computational biochemistry, computational biophysics, optimization and molecular dynamics, structural bioinformatics, biological mathematics, and related fields. It serves as an accessible introduction to these disciplines and is also an excellent teaching resource for students. |
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