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1. |
Record Nr. |
UNINA9910496036603321 |
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Autore |
Portes Jacques |
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Titolo |
Europe and America Criss-Crossing Perspectives, 1788-1848 / / Jacques Portes |
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Pubbl/distr/stampa |
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Paris, : Éditions de la Sorbonne, 2020 |
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ISBN |
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Descrizione fisica |
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1 online resource (220 p.) |
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Collana |
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Altri autori (Persone) |
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BlairJohn G |
Fabris GrubeAlberta |
GellénJózsef |
GranqvistRaoul |
GrmelaJosef |
HefferJean |
KossuthLajos |
MicksGabriella |
PortesJacques |
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Soggetti |
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History |
opinion publique |
New World |
EAAS |
criss-crossing |
personality |
setback |
Geography |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Dans ce livre sont réunies certaines des communications présentées lors de l’atelier : Europe Viewing America, America viewing Europe de la conférence de l’EAAS à Budapest en mars 1986. Ces textes viennent de divers pays, leurs auteurs sont aussi bien des historiens que des littéraires ou des "civilisationistes". Au premier coup d’œil, l’ouvrage |
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peut sembler hétéroclite, toutefois, sa richesse apparaît rapidement. Il s’agit d’une histoire faite d’éloignement et de rapprochement. L’Euro et les Etats-Unis étaient alors aussi éloignés l’un de l’autre qu’ils pouvaient être proches, surtout dans une période où les seconds dépendaient encore de la première, tout en cherchant à développer leur propre personnalité. C’est alors que l’Europe acquit sa fascination pour Nouveau Monde, malgré des réticences. Les liens entre les Etats-Unis et l’Europe sont, encore aujourd’hui faits d’étrangeté et de familiarité. Il est important d’en savoir plus sur les racines de notre attitude actuelle. Laissons les lecteurs les découvrir |
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2. |
Record Nr. |
UNINA9910751389003321 |
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Autore |
Chan Anthony T. C |
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Titolo |
Immunotherapy for Head and Neck Cancer / / edited by Anthony T. C. Chan, Brigette B.Y. Ma |
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Pubbl/distr/stampa |
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Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2023 |
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ISBN |
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Edizione |
[1st ed. 2023.] |
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Descrizione fisica |
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1 online resource (151 pages) |
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Collana |
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Cancer Immunotherapy, , 2662-8392 ; ; 1 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Immunotherapy |
Oncology |
Medical radiology |
Surgery |
Otolaryngology |
Radiation Oncology |
Otorhinolaryngology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Immunological Landscape of Head and Neck Cancer: Mechanisms of Immune Escape and the Tumor Microenvironment -- Drug Targets and Strategies in the Clinical Development of Immunotherapy for Head and Neck Cancer -- Immunotherapy in Locally Advanced Nasopharyngeal |
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Carcinoma -- Immunotherapy in Recurrent and Metastatic Nasopharyngeal Carcinoma -- Beyond PD-1/PD-L1 Immune Checkpoint Inhibitors: Other Targets and Approaches for Head and Neck Cancer -- Translational and Clinical Approach to Combining Immunotherapy with Radiotherapy in the Treatment of Head and Neck Cancer -- Clinical Application of Immunotherapy in the Perioperative Management of Head and Neck Cancer -- The Role of Immune Checkpoint Inhibitors in the Treatment of Less Common Head and Neck Cancers -- Development of Predictive Biomarkers to Immunotherapy in Head and Neck Cancer. . |
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Sommario/riassunto |
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This book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers. Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours has gradually brought immunotherapy into mainstream oncological practice in recent years. Besides immune-checkpoint proteins inhibitors, other forms of immunotherapy such as vaccines, EBV or HPV-targeting therapies and cellular therapies are actively being investigated in clinical trials, either alone or in combination with other conventional treatments such as radiotherapy, chemotherapy and surgery. In clinical setting, the practicing oncologist need to be familiar with some unusual patterns of immunological response such as pseudo-progression and hyper-progression in patients with head and neck cancers who are undergoing treatment with immune-checkpoint inhibitors. Furthermore, the unique side effects of immune-checkpoint inhibitors such as autoimmune toxicities need to be recognized early and treated expediently. The development of biomarkers in predicting response to immune-checkpoint inhibitors has played pivotal roles in selecting patients for immunotherapy in practice or as an enrichment strategy in clinical trials. There are now emerging data on the clinical utility of biomarkers such as PD-L1 expression (Combined Positive Score), gene signatures and tumor mutational burden. This book is an invaluable companion to all those who are involved in research and clinical management of patients with head and neck cancers from any endemic regions. . |
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