1.

Record Nr.

UNINA9910743229103321

Titolo

Homocysteine Metabolism in Health and Disease / / edited by Govind Prasad Dubey, Krishna Misra, Rajesh K. Kesharwani, Rudra P. Ojha

Pubbl/distr/stampa

Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2022

ISBN

9789811668661

9811668663

9789811668678

9811668671

Edizione

[1st ed. 2022.]

Descrizione fisica

1 online resource (285 pages)

Collana

Biomedical and Life Sciences Series

Disciplina

616.1071

Soggetti

Human physiology

Metabolism

Nervous system - Diseases

Developmental neurobiology

Stem cells

Human Physiology

Neurological Disorders

Development of the Nervous System

Stem Cell Biology

Lingua di pubblicazione

Inglese

Formato

Materiale a stampa

Livello bibliografico

Monografia

Nota di contenuto

Module 1 -- Nutrition and Health -- Module 2_Disease -- Module 3_Advanced Research .

Sommario/riassunto

This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association



of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.