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Record Nr. |
UNINA9910741183103321 |
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Titolo |
Iron acquisition by the genus Mycobacterium : history, mechanisms, role of siderocalin, anti-tuberculosis drug development / / B. Rowe Byers, editor |
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Pubbl/distr/stampa |
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Cham [Germany], : New York, : Springer, 2013 |
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ISBN |
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Edizione |
[1st ed. 2013.] |
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Descrizione fisica |
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1 online resource (96 p.) |
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Collana |
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SpringerBriefs in molecular science. Biometals, , 2212-9901 |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Iron proteins |
Mycobacteria |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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A History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform. |
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Sommario/riassunto |
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Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates. |
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