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Record Nr. |
UNINA9910739442903321 |
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Titolo |
Protein tyrosine phosphatase control of metabolism / / Kendra K. Bence, editor |
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Pubbl/distr/stampa |
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New York, : Springer, 2013 |
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ISBN |
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Edizione |
[1st ed. 2013.] |
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Descrizione fisica |
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1 online resource (279 p.) |
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Altri autori (Persone) |
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Disciplina |
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Soggetti |
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Protein-tyrosine phosphatase - Physiological effect |
Metabolism - Regulation |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Description based upon print version of record. |
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Nota di bibliografia |
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Includes bibliographical references and index. |
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Nota di contenuto |
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Redox Regulation of PTPs in Metabolism: Focus on Assays -- Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling -- Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism -- PTP1B and TCPTP in CNS Signaling and Energy Balance -- PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress -- Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling -- PTP1B in Obesity-Related Cardiovascular Runction -- Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism -- Metabolic Effects of Neural and Pancreatic SHP2 -- Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism -- The Role of LMPTP in the Metabolic Syndrome -- Mitogen-Activated Protein Kinase Phosphatases in Metabolism -- Glycogen Metabolism and Lafora Disease -- Index. |
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Sommario/riassunto |
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Tyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes. Recent studies into PTP function |
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